Clinical trials: Polymorphism, Genetic
Dyslipidemia, Impaired Glucose Tolerance
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose
The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean…
- Trial name
- NCT02938091
- Testing
- High-fat diet, Low-fat diet
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tufts University
Diabetes Mellitus, Type II
Effect of SLC30A8 rs13266634 Genetic Polymorphism on Zinc Supplementation and Glycemic Control in Egyptian Patients With Type 2 Diabetes Mellitus
Study whether SLC30A8 rs13266634 polymorphism is associated with type 2 diabetes mellitus (T2DM) susceptibility in Egyptian patients and study effect of Zn supplementation on glycemic control in patients with type 2 diabetes
- Trial name
- SLC30A8 (NCT03112382)
- Testing
- zinc supplement plus vitamin A and E, vitamin A and E
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alopecia Areata(AA)
Impact of NR3C1 rs41423247 (BclI) Polymorphism on Disease Severity in Alopecia Areata
Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response.
- Trial name
- NR3C1 and AA (NCT07455708)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Healthy
Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects
Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects
- Trial name
- sibu (NCT01421706)
- Testing
- Sibutramine-clopidogrel, sibutramine-Clarithromycin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inje University
Diabetic Retinopathy, Diabetic Macular Edema
Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema
Background: Diabetic macular edema (DME) is a common condition in people with diabetes. DME occurs when blood vessels in the eye leak fluid, resulting in swelling inside the back of the eye and progressive vision loss.
- Trial name
- NCT01168258
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- National Eye Institute (NEI)
Peripartum Cardiomyopathy
Irisin Expression and Gene Polymorphism With Peripartum Cardiomyopathy.
this is an observertional study aimed at Study the association between the level of irisin expression and (Fibronectin Type III Domain Containing 5 (FDNC5) gene polymorphism in female patients with peripartum cardiomyopathy.
- Trial name
- NCT04927715
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Exposures Associated With Pregnancy, Delivery and Lactation
Impact of Perinatal Exposure to Non-caloric Sweeteners on Food Preferences and Weight Gain in the First Year of Life
During last years, non-caloric sweeteners (NCSs) have been increasingly incorporated into foodstuffs in replacement of sucrose in Chile.
- Trial name
- NCT03972176
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Chile
Patients Treated by Means of 1 or More Dental Implants
Impact of Genetic Polymorphisms on Dental Implant Loss
Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007.
- Trial name
- Polymorphism (NCT01274442)
- Testing
- anamnesis, oral examination, Blood sample
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Ghent
Schizophrenia
Therapeutic Drug Monitoring for Individualized Clozapine Therapy
The purpose of this study is to evaluate the factors affecting the occurrence of adverse drug reactions (glucose and lipid metabolism abnormality, changes in liver function index and sleeping tendency) and clinical effects in…
- Trial name
- NCT03523741
- Testing
- Clozapine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Type 2 Diabetes Mellitus
Efficacy Study of Pioglitazone and Metformin and Association Between Pioglitazone Response and Peroxisome Proliferator-activated Receptor Gamma Gene Variants in Bangladeshi Type 2 Diabetes Mellitus Subjects
The present study was undertaken to assess the efficacy and safety of two different insulin sensitizers (namely Pioglitazone and Metformin) among subjects with type 2 diabetes mellitus (T2DM) in Bangladesh.
- Trial name
- T2DMCT (NCT01589445)
- Testing
- Pioglitazone hydrochloride, Metformin hydrochloride
- Where
- Bangladesh
- Volunteers
- 77 people
- Sponsor
- University of Dhaka
Paclitaxel Adverse Reaction, Neuropathy;Peripheral
ABCB1 SNPs as Predictors of PIPN
The study aim is to determine the allele frequencies of 1236 G>A and 3435 G>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline…
- Conditions
- Paclitaxel Adverse Reaction, Neuropathy;Peripheral, Breast Cancer
- Trial name
- NCT05093023
- Testing
- Real-Time PCR
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Healthy Volunteers
Genetic and Metabolism of Post-prandial HDL Particles
Reverse cholesterol transport (RCT) pathway explains the anti-atherosclerosis role of HDL. Post prandial hypertriglyceridemia is highly predictive of atherosclerosis.
- Trial name
- HDL-PP (NCT03109067)
- Testing
- Standardized meal
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity, Childhood, Asthma in Children
Asthma and Obesity Diet Versus Exercise
Obesity is recognized as a pro-inflammatory condition associated with multiple chronic diseases, including asthma. The specific mechanisms linking asthma and obesity remain hypothetical.
- Conditions
- Obesity, Childhood, Asthma in Children, Inflammatory Response, Metabolic Syndrome
- Trial name
- NCT03644355
- Testing
- Lifestyle counseling
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Alzheimer's Disease
Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to determine the characteristics of those who obtain genetic susceptibility testing for Alzheimer's disease with APOE disclosure and to study the psychological and behavioral consequences of providing…
- Trial name
- REVEAL I (NCT00571025)
- Testing
- APOE Disclosure
- Where
- 3 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Atopic Dermatitis
Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism
This protocol is primarily looking to see if the IL-4Ra R576 polymorphism is associated with increased clinical, immunological and microbial markers of disease activity in patients with Atopic dermatitis.
- Trial name
- NCT04455906
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Boston Children's Hospital
Ventricular Arrythmia
China Inherited Ventricular Arrhythmias Registry
This is an observational, prospective, multi-center registry, aiming at building a risk stratification for malignant inherited ventricular arrhythmias, including Brugada syndrome(Brs)、Long QT syndrome(LQTS)、Short QT…
- Trial name
- NCT03880708
- Where
- China
- Volunteers
- 500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Vaccine Response Impaired, Allogeneic Stem Cell Transplantation
Role of Interferon-λ and Vaccine Response
The following observational study will investigate whether the vaccine response (antibodies, T and B cells) after allogeneic stem cell transplantation is influenced by genetic polymorphisms in the interferon lambda signal.
- Trial name
- NCT03467074
- Testing
- influenza A/B vaccine
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Substance-Related Disorders
Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone
The purpose of this study is to determine to what extent CYP2B6, CYP3A4, and MDR1 polymorphisms affect the metabolism of methadone.
- Trial name
- NCT00504413
- Testing
- midazolam(drug), digoxin (drug), Bupropion (drug), Methadone (drug)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington