Clinical trials: Point-of-Care Systems
Coronary Artery Disease
Pre-hOspital Evaluation of Chest Pain Patients With sUspected Non ST-segment eLevation myocARdial Infarction Using the HEART-score With a Troponin Point-of-care Test
Overcrowding in the emergency department is an increasing problem in hospitals worldwide. Point-of-care Troponin (POC cTn) testing combined with a well investigated risk stratification tool (HEART-score) used in the ambulance may…
- Trial name
- POPular HEART (NCT04851418)
- Testing
- Possible NSTE-ACS
- Where
- 2 sites in Netherlands
- Volunteers
- 650 people
- Sponsor
- St. Antonius Hospital
Abdominal Pain
Abdominal Pain Management and Point-of-care Ultrasound in the Emergency Department
Background: Abdominal pain is one of the most common reasons for admission to the emergency department (ED). This study aimed to investigate the effect of point-of-care ultrasound (POCUS) performed during the initial evaluation…
- Trial name
- NCT05402774
- Testing
- point-of-care ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Breast Cancer
A Prospective Validation Study of a Rapid Point-of-Care Breath Test for Breast Cancer
This is a multicenter, blinded prospective study of 2,000 women undergoing mammography for breast -related symptoms or signs. Breath tests will be performed in order to demonstrate that the outcome of mammography results combined…
- Trial name
- NCT02888366
- Where
- 4 sites in United States
- Volunteers
- 500 people
- Sponsor
- Menssana Research, Inc.
Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma
Saliva-based Detection of CD44
The purpose of this study is to test the ability of OncAlert™ to screen for cancer and the reappearance of cancer. OncAlert™ was developed by Vigilant Biosciences, a collaborator in this research study.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Oropharynx, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- Detect 44 (NCT03148665)
- Testing
- OncAlert
- Where
- 4 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Joseph Califano
Chest Pain, Acute Coronary Syndrome
Improving the Accuracy of Referrals of Patients With Chest Pain
This is a multicenter, prospective, investigator-initiated, randomized controlled trial aiming to reduce the percentage of non-cardiac chest pain (NCCP) patients admitted to the cardiac emergency department (ED) by performing the…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Myocardial Ischemia
- Trial name
- URGENT2 (NCT04904107)
- Testing
- modified HEART score (including POC hs cTnI analysis), Standard care and triage according to the local (EMT)protocol.
- Where
- 2 sites in Netherlands
- Volunteers
- 852 people
- Sponsor
- VieCuri Medical Centre
Pregnancy Postpartum
QUANTRA® References Range Protocol in Pregnancy and Postpartum
Postpartum hemorrhage (PPH) remains the leading cause of maternal death. PPH associated coagulopathy varies and their treatments (tranexamic acid, fibrinogen concentrates,plasma, platelets need to be targeted and administrated…
- Trial name
- QUANTRA®_GPP (NCT04753671)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Lille
Vaping
Point-of-Care Ultrasound (POCUS) Findings and Impact on Vaping
Vaping has emerged as a prominent public health crisis in recent years. In 2023, the National Youth Tobacco Survey found that more than 2.1 million adolescents endorse vaping, with 25% of those endorsing daily use.
- Trial name
- NCT06335329
- Testing
- Discussion of point-of-care ultrasound lung findings
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pain
Effectiveness of Oral Sucrose During Lung Ultrasound
Background: control of pain in neonates has an important role in preventing long- term effects on neurodevelopment and pain reactivity.
- Trial name
- NCT05717088
- Testing
- 24% Sucrose solution
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Mount Sinai Hospital, Canada
Meningitis, Pediatric Infectious Diseases
Paediatric Infections Point-Of-Care
This study aims to identify the aetiology of childhood meningitis in Southwestern Uganda and develop and evaluate new methods for point-of-care diagnosis of childhood meningitis in a low-income setting.
- Trial name
- PI-POC (NCT03900091)
- Testing
- Multiplex PCR assay for meningitis, Multiplex vertical flow microarrray assay for meningitis, Profiling of blood proteins by multi-analyte Profiling technology
- Where
- 2 sites in Uganda
- Volunteers
- 351 people
- Sponsor
- Karolinska Institutet
Kidney Transplant, Kidney Disease, Chronic
Clinical Evaluation of the Nova Max Pro StatSensor Device
Blood creatinine is an important biomarker used to monitor kidney function. In patients with chronic kidney disease or patients who have received a kidney transplant, careful and frequent monitoring of kidney function is required…
- Trial name
- NCT07392710
- Testing
- Nova Max Pro StatSensor device
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
PrEP Adherence Monitoring
A Hybrid Effectiveness-Implementation Trial of Urine Point-of-Care Assay to Increase PrEP Adherence Among Women in Kenya
The goal of this randomized trial study is to learn if drug-level feedback counseling works to improve oral PrEP adherence in adolescent girls and young women. Researchers will compare urine TFV assay positivity between arms.
- Trial name
- NCT07725679
- Testing
- POC urine TFV test with DLFB
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pneumonia, Pediatric Disorder
Standardization of Mid-Level Providers Using Point of Care Ultrasound to Diagnose Pediatric Pneumonia
The POCUS training program aims to bring sustainable, affordable access to POCUS to patients in need of diagnostic services in Uganda.
- Conditions
- Pneumonia, Pediatric Disorder, Diagnostic and Monitoring Radiological Devices Associated With Adverse Incidents
- Trial name
- POCUS (NCT03969342)
- Testing
- Point of care ultrasound training
- Where
- Uganda
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bridge to Health Medical and Dental
Leukemia, Lymphoma
The PACMAN-Hu19 Trial: a Study of the Safety and Feasibility of Locally Produced, CD19-targeted and Human CAR T-cell Therapy in Children and Young Adults With Relapsed or Refractory B-cell Malignancies
PACMAN is a phase I/II single arm, open-label, multi-center study evaluating the safety of human CD19 CAR-T (huCAR19) produced locally using the Miltenyi Prodigy in children, adolescents and young adults with relapsed/refractory…
- Trial name
- PACMAN (NCT07020260)
- Testing
- CAR T-cell and Cellular Therapies
- Where
- 2 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Septic Shock
POCUS-Guided Esmolol in Septic Shock: A Pilot RCT
The goal of this pilot clinical trial is to determine if conducting a larger study using point-of-care ultrasound (POCUS) to guide beta-blocker therapy in patients with septic shock is feasible.
- Trial name
- Epic-Beta (NCT07313605)
- Testing
- Esmolol
- Volunteers
- 100 people
- Sponsor
- John Basmaji
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Intracranial Hypertension, Increased Intracranial Pressure
Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure
Raised intracranial pressure (ICP) is a serious medical emergency that requires prompt recognition to prevent brain damage. While invasive pressure monitoring and brain CT scans are commonly used, bedside transorbital…
- Conditions
- Intracranial Hypertension, Increased Intracranial Pressure, Brain Edema, Traumatic Brain Injury
- Trial name
- NCT07799714
- Volunteers
- 85 people
- Sponsor
- Assiut University
Renal Insufficiency, Acute Kidney Injury
Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast
Point-of-care (POC) creatinine devices allow rapid measurement of creatinine levels and calculation of estimated glomerular filtration rate (eGFR) which give an indication of renal function.
- Conditions
- Renal Insufficiency, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- EPIC (NCT04597892)
- Testing
- serum creatinine assay
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Syphilis
Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Department
The purpose of this study is to offer routine lab-based and rapid point of care (POC) syphilis diagnostic testing in the emergency department (ED) and obstetrical (OB) triage , thereby increasing screening and treatment…
- Trial name
- NCT06645106
- Testing
- Rapid Point of Care (POC) Syphilis testing
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury
Fresh Intravenous Blood Samples for TBI Diagnostic Assay Development With Philips Point of Care System
The purpose of this study is to collect fresh whole blood within 12 hours from suspected mild head injury (Glasgow Coma Scale score 13-15) from subjects over the age of 18, to help verify that both UCH-L1 and GFAP can be detected…
- Trial name
- FIRST DOWN (NCT03060109)
- Testing
- Blood draw within 12 hours of injury
- Where
- 4 sites in Netherlands
- Volunteers
- 317 people
- Sponsor
- Banyan Biomarkers, Inc
Infection, Bacterial, Infection, Fungal
Point-of-care Tests for Bacterial Vaginosis and Candidosis
Vaginal infection in early pregnancy is associated with an increased risk of spontaneous preterm delivery and late miscarriage. Most studies presume that vaginal infections are responsible for up to 40% of preterm birth.
- Conditions
- Infection, Bacterial, Infection, Fungal, Preterm Birth
- Trial name
- NCT04287504
- Testing
- SavvyCheck Vaginal Yeast Test, OSOM BVBLUE Test
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
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