Clinical trials: Pneumoperitoneum
Hernia, Ventral, Neuromuscular Blockade
Prospective Randomized Trial of Moderate vs Deep Neuromuscular Blockade During Laparoscopic Ventral Hernia Repair
The proposed study aims to assess the effect of different levels of muscle relaxation on the success of low-pressure insufflation, surgical conditions and patient recovery following laparoscopic repair of a ventral hernia (VHR)…
- Conditions
- Hernia, Ventral, Neuromuscular Blockade, Pneumoperitoneum
- Trial name
- NCT03201744
- Testing
- Patients will be randomized to moderate (TOF 1-2) or deep (post tetanic count 1-2) relaxation. Low pressure insufflation (start pressure set at 8 mm Hg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stony Brook University
Pneumoperitoneum
Intra-ocular Pressure and Ventilation
Background: Positive pressure pneumoperitoneum (PP) may involve adverse pathophysiological changes, including increased intra-thoracic and ocular pressure, when combined with standard ventilation.
- Trial name
- pressure (NCT02731404)
- Testing
- HFJV ventilation, IPPV ventilation
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Laparoscopic Surgery
Device to Assist With Abdominal Access During Laparoscopic Surgery
The purpose of this study is to assess the safety and ease of use of a TauTona Pneumoperitoneum Assist Device (TPAD) to assist with obtaining peritoneal access with a Veress needle, and for placing a primary trocar, during…
- Trial name
- NCT04392635
- Testing
- TauTona Pneumoperitoneum Assist Device (TPAD), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Stanford University
Optic Nerve Sheath Diameter, Pneumoperitoneum
Comparison of Changes of ONSD Between Groups of Laparoscopic Surgery With and Without Epidural Saline Injection
This study targets patients undergoing laparoscopic gastric cancer surgery. The investigators would like to compare two factors that influence intracranial pressure through optic nerve sheath diameter measurement.
- Conditions
- Optic Nerve Sheath Diameter, Pneumoperitoneum, Epidural
- Trial name
- NCT04758013
- Testing
- Epidural injection through thoracic epidural catheter, Without epidural injection
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Perioperative Care, Fluid Therapy
Paired Comparison of SVV and PVI Accuracy
This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a…
- Conditions
- Perioperative Care, Fluid Therapy, Monitoring, Physiologic, Hemodynamics
- Trial name
- NCT07260890
- Testing
- Stroke Volume Variation (SVV) monitoring, Pleth Variability Index (PVI) monitoring
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Laparoscopic Gynecological Surgery
Effects of Standard and Modified Z-Trendelenburg Positions on Cerebral Oxygenation and Optic Nerve Sheath Diameter
The purpose of this study is to compare the effects of the standard Trendelenburg position and the modified Z-Trendelenburg position on cerebral oxygenation and optic nerve sheath diameter (ONSD) in patients undergoing…
- Trial name
- MOD-TREND (NCT07632287)
- Testing
- Standard Trendelenburg Position, Modified Z-Trendelenburg Position
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Intervention Affecting Autonomic Nervous System
Autonomic Nervous System Modulation During Laparoscopic Prostatectomy
The purpose of this study is to measure the variations of autonomic nervous system (ANS) modulation directed to the heart and vessels induced by pneumoperitoneum and steep trendelenburg position.
- Trial name
- NCT01927380
- Testing
- steep trendelenburg position with pneumoperitoneum
- Where
- Italy
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Laparoscopic Surgery
The Use of Tidal Volume Challenge of Dynamic Parameters During Laparoscopic Surgery
Laparoscopy is increasingly used for major abdominal and pelvic surgery. As this approach is also recommended in elderly patients with serious comorbidities, optimal fluid therapy guidance during this procedure is important.
- Trial name
- NCT03467711
- Testing
- tidal volume challenge, volume expansion
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Gallstones, Pain
Comparison of the Efficacy of Different Analgesic Strategies for Pain Control After Laparoscopic Cholecystectomy (LC)
The investigators collected 200 patients underwent safe uncomplicated laparoscopic cholecystectomy, then different strategies of pain control are used.
- Trial name
- Randomized (NCT07897435)
- Testing
- Low pneumoperitoneum, Local anaesthetic instillation to gallbladder bed
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain, Inflammatory, Pain Management
Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy
vNOTES, initially employed for cholecystectomy, appendectomy, and nephrectomy, made its debut in the field of gynecologic surgery in 2012.
- Trial name
- Vnotes (NCT06944015)
- Testing
- normal saline
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Intracranial Hypertension, Brain Edema
Optical Nerve Sheath Changes During Head Down Laparoscopy
Patient undergoing laparoscopic radical prostatectomy in steep trendelenburg position are at risk to develop complication from brain edema.
- Conditions
- Intracranial Hypertension, Brain Edema, Pneumoperitoneum, Surgery, Laparoscopic
- Trial name
- NCT03957837
- Testing
- Optical nerve sheath diameter ultrasound measurement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Obesity, Morbid, Bariatric Surgery Candidate
Optical Trocar to Create the Pneumoperitoneum in Bariatric Patients
Laparoscopic bariatric surgery are becoming the most used procedure to treat the obesity. To facilitate safe initial access to the abdominal cavity, we insert an optical viewing trocar at the left hypocondrium.
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, Surgery-Complications
- Trial name
- NCT06207357
- Testing
- optical trocar to create the pneumoperitoneum for bariatric surgery
- Where
- Italy
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Gynecologic Surgery
Low Versus Standard Pressure Pneumoperitoneum
The role of laparoscopy in gynecological and gyne-oncological surgery has dramatically increased over the past decades. Although laparoscopic procedure has several advantages over open surgery such as reduced blood loss, faster…
- Trial name
- NCT04947982
- Testing
- carbon dioxide
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Pneumoperitoneum
Evaluating the Novel Veress Plus Needle
18 participants (novices, intermediates and experts) performed in total 248 insertions in a systematic way on Thiel embalmed bodies with wide and small bore versions of the conventional VNc (conventional Veress Needle) and the…
- Trial name
- Veress+ (NCT05613959)
- Testing
- Veress +, Conventional Veress
- Where
- Malta
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Prof Jean Calleja-Agius
Obese Patients, Laparoscopic Colorectal Surgery
Pharmacodynamics of Injection of Cisatracurium Base on Lean Body Mass Pattern to Maintain Deep Neuromuscular Blockade in Obese Patients
To observe the pharmacodynamics of intravenous injection of cisatracurium to maintain deep neuromuscular blockade in obese patients with lean body mass in laparoscopic colorectal surgery
- Trial name
- NCT05391958
- Testing
- base on Lean Body Mass Pattern, base on Actual Body Weight, obese patients
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Surgery, Laparoscopic
Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain
This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery.
- Conditions
- Surgery, Laparoscopic, Laparoscopy, Penumoperitoneum
- Trial name
- NCT06504277
- Testing
- Low Pressure Penumoperitoneum, Standard Pressure Group (No intervention- active comparator)
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Acute Kidney Injury (Nontraumatic), Pneumoperitoneum
A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these…
- Trial name
- NCT05612802
- Testing
- IGF-1
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baskent University
Free Air in Abdomen
Point of Care Ultrasound for Diagnosis of Abdominal Free Air
This study evaluates the ability of ultrasound to identify intraperitoneal free air. The study will consist of blinded review of abdominal ultrasound images of patients before and after laparoscopic surgery, a procedure which…
- Trial name
- NCT03719872
- Testing
- Pre-Operative Transabdominal Ultrasound, Post-Operative Transabdominal Ultrasound
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- David Blehar
Benign Neoplasm of Cervix Uteri, Gynecological Laparoscopy
The Effects of CO2 Pneumoperitoneum at Different Temperature in Laparoscopic Surgery
Objective: It is recommended to heat and humidify CO2 in laparoscopic surgery to prevent postoperative pain and hypothermia but information about its effects on hemodynamic and respiratory parameters is limited.
- Trial name
- NCT04508387
- Testing
- Group HH (heated-humidified)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
Elective Laparoscopic Cholecystectomy
The Effect of Respiratory Exercises on Abdominal Distension in Laparoscopic Cholecystectomy Patients
Laparoscopic cholecystectomy is the first-line treatment for symptomatic gallstones. Pneumoperitoneum is the process of expanding the abdominal cavity during the surgical procedure by introducing CO2 gas into the abdomen to widen…
- Trial name
- NCT06069557
- Testing
- Respiratory exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University