Clinical trials: Pneumonia, Aspiration
Pneumonia
Effect of Pursed-Lip Breathing on Physiological Parameters and Discharge Readiness in Children With Pneumonia
This study aims to evaluate the effects of Pursed-Lip Breathing (PLB) exercises on physiological parameters (such as respiratory rate, heart rate, and oxygen saturation) and discharge readiness in children diagnosed with…
- Trial name
- PLB-PEDPNEU (NCT07106203)
- Testing
- Pursed-Lip Breathing (PLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Ataturk University
Pneumonia, Aspiration
Risk of Respiratory Complications Following Gastrointestinal Endoscopy Under Monitored Anesthesia Care
The purpose of this study is to investigate the incidence of respiratory complications after gastroenteroscopy, and establish a Logistic regression model to analyze the related risk factors of respiratory complications.
- Trial name
- NCT06705894
- Where
- China
- Volunteers
- 10,313 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Covid19, Infective Pneumonia
The Effect of Inspiratory Muscle Training in Post COVID-19 Patients
The COVID-19 infection, which is considered as a pandemic by the World Health Organization, affects the whole world. COVID-19 is an infectious respiratory disease caused by SARS-CoV-2.
- Trial name
- NCT04811859
- Testing
- Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
Acid Aspiration Syndrome
Detection of Silent Aspiration Events Utilizing pH/Impedance Probes in Hospitalized Patients
Monitoring and quantification of reflux events in high risk critically ill inpatients and lower risk general medical/surgical inpatients, with comparison to relevant clinical variables.
- Trial name
- NCT02720029
- Testing
- pH/impedance monitor
- Sponsor
- Vanderbilt University
SARS-CoV-2 Infection
SARS-CoV-2-Neutralizing Monoclonal COVID-19 Antibody DZIF-10c by Inhalation
This is the first-in-human phase 1/2a trial of the inhaled administration of the SARS-CoV-2-neutralizing monoclonal antibody DZIF-10c in healthy volunteers and SARS-CoV-2-infected individuals.
- Trial name
- NCT04631705
- Testing
- DZIF-10c
- Where
- 6 sites in Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Tracheostomy Complication, Critical Illness
PUSH-IT Continuing Enteral Feeds for Tracheostomy
The goal of this clinical trial is to evaluate nutrition administration in the time around the tracheostomy in patients with breathing tubes.
- Conditions
- Tracheostomy Complication, Critical Illness, Nutritional Deficiency
- Trial name
- NCT05906472
- Testing
- Feeds continued, Feeds held
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- State University of New York at Buffalo
Respiration Disorders, Swallowing Disorder
Artificial Intelligence in Diagnosing Dysphagia Patients
In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device.
- Conditions
- Respiration Disorders, Swallowing Disorder, Phonation Disorder, Stroke
- Trial name
- NCT05098808
- Testing
- Acoustic features (from signals obtained during phonation)
- Where
- South Korea
- Volunteers
- 449 people
- Sponsor
- The Catholic University of Korea
Aspiration Pneumonias
Continuous Supraglottic Aspiration in Intubated and Mechanically Ventilated Patients: the "SUPRAtube" Device
Purpose of the trial: Evaluate the efficacy and safety of the device of self-invention of continuous oropharyngeal aspiration denominated "SUPRAtube" in patients with orotracheal intubation and mechanical ventilation.
- Trial name
- Supratube (NCT03573635)
- Testing
- Supratube, Reference
- Where
- Colombia
- Volunteers
- 38 people
- Sponsor
- Fundación Cardiovascular de Colombia
COVID-19, Viral Pneumonia
Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) Pneumonia
This single-center, prospective, open-label, comparator study, blind for central accessor evaluates the efficacy, safety of inhalations of low-doses of melphalan in patients with pneumonia with confirmed or suspected COVID-19.
- Trial name
- MICOV (NCT04380376)
- Testing
- Melphalan, Standard of care
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
COVID-19
The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers
Phase 1 randomized, vehicle-controlled, blinded study to assess the safety, tolerability, and PK of single ascending doses of inhaled TLC19 in healthy volunteer subjects.
- Trial name
- NCT04697654
- Testing
- TLC19, TLC19 Vehicle
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taiwan Liposome Company
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
To compare the use of pentamidine aerosol (inhaled mist) with the standard intravenous method of administration in patients with AIDS related Pneumocystis carinii pneumonia (PCP), to measure the amount of pentamidine aerosol that…
- Trial name
- NCT00000722
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Aspiration of Subglottic Secretions
Aspiration of Subglottic Secretions Using Hi-Lo Evac Endotracheal Tube: Tube Size and Incidence of Suction Lumen Dysfunction
To evaluate the correlation between endotracheal tube size and incidence of dysfunction of suction lumen of Hi-Lo Evac endotracheal tube in critically ill patients who required mechanical ventilation for more than 48 hours.
- Trial name
- NCT00450476
- Testing
- Hi-Lo Evac Endotracheal Tube
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University Hospital, Alexandroupolis
Critical Illness, Length of Stay
Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
- Conditions
- Critical Illness, Length of Stay, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT00466492
- Testing
- Sedation or no sedation during mechanical ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
COVID-19, SARS-CoV2 Infection
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
This is a phase 1 study in healthy volunteers who have received at least three doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT05094609
- Testing
- Ad5-triCoV/Mac, ChAd-triCoV/Mac
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aspiration Pneumonia, Cricoid Cartilage
The Cricoid Pressure in Pediatric Patients
Because the cricoid force in children has not been quantified, clinicians wrongly used the 'adult' force. it has been found that the use of the adult force can result in compression and distortion of the child's airway and can…
- Conditions
- Aspiration Pneumonia, Cricoid Cartilage, Pediatric
- Trial name
- NCT05290844
- Testing
- cricoid pressure
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Procare Riaya Hospital
COVID-19
Inhaled Ivermectin and COVID-19
Coronavirus disease-19 is global healthcare crisis. Till May 20, 2020, there were approximately 4,789,205 cases and 318,789 related mortalities were identified globally.
- Trial name
- CCOVID-19 (NCT04681053)
- Testing
- Ivermectin Powder
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulmonary Infection, Respiratory Insufficiency
Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery
Perioperative changes in regional ventilation by pulmonary electrical impedance tomography and spirometry will be investigated in patients at risk for postoperative pulmonary complications.
- Conditions
- Pulmonary Infection, Respiratory Insufficiency, Aspiration Pneumonitis, Bronchospasm
- Trial name
- NCT02779595
- Testing
- Perioperative pulmonary function tests
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Wuerzburg University Hospital
Aspiration Pneumonia
Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Cesarean Section
the risk of aspiration pneumonitis during cesarean sections has significantly decreased. Nevertheless, precaution against gastric aspiration is still vital in patients in whom regional anesthesia contraindicated or in whom…
- Trial name
- NCT04157998
- Testing
- normal saline, Metoclopramide 10mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pneumonia
Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment (BY2001/M1-007)
Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygenation impairment.
- Trial name
- NCT00074906
- Testing
- Venticute
- Where
- 92 sites in Australia, Austria and 15 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda