Clinical trials: Pneumococcal Carriage
Mycobacterium Avium-intracellulare Infection, HIV Infections
Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048
Some people who have taken azithromycin to prevent MAC (Mycobacterium avium Complex, a bacterial infection common in HIV-infected persons) have been found to carry antibiotic-resistant bacteria (germs that grow despite the…
- Conditions
- Mycobacterium Avium-intracellulare Infection, HIV Infections, Pneumococcal Infections
- Trial name
- NCT00000933
- Where
- 15 sites in United States
- Volunteers
- 326 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Subjects
Study Evaluating the Nasopharyngeal Carriage in Healthy Children
The purpose of this study is to assess the prevalence of pneumococcal stereotypes in the nasopharynx of healthy children and to describe the changes of nasopharyngeal carriage at different ages over time.
- Trial name
- Carriage (NCT00768833)
- Where
- Germany
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease (COPD)
Seasonal Trends in Pneumococcal Carriage in COPD Patients
Patients suffering from chronic obstructive pulmonary disease (COPD) commonly get exacerbations of their illness which have many potential triggers including infection.
- Trial name
- Helios (NCT02535546)
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- Beaumont Hospital
Streptococcus Pneumoniae Infections
Prevalence of Nasopharyngeal Carriage of Streptococcus Pneumoniae in Healthy Children of 12-18 Months in 6 Cities, China
This study is to observe the carriage rate of Streptococcus pneumoniae (S.p.), Haemophilus influenzae Type B (Hib) and Moraxella catarrhalis (M.Cat.) in healthy Chinese children aged 12-18 months in order to estimate the…
- Trial name
- NCT00952367
- Testing
- Nasopharyngeal swab
- Where
- 6 sites in China
- Volunteers
- 3,641 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pneumococcal Carriage
Post Pandemic Pneumococcal Carriage Among Children and Adults
The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city.
- Trial name
- NCT06373328
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Infections, Streptococcal, Streptococcus Pneumoniae
Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A
The aim of this study is to assess the effectiveness of GSK Biologicals' pneumococcal conjugate vaccine (GSK1024850A) in preventing invasive disease caused by S. pneumoniae or H.
- Trial name
- NCT00839254
- Testing
- Pneumococcal conjugate vaccine Synflorix (GSK1024850A), GSK Biologicals' Engerix TM vaccine (Hepatitis B vaccine), GSK Biologicals' Havrix TM vaccine (Hepatitis A vaccine)
- Where
- 15 sites in Finland
- Volunteers
- 6,181 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infections, Streptococcal
Impact of GSK Biologicals' 2189242A Vaccine on Nasopharyngeal Carriage, Safety & Immunogenicity in Children & Infants
This study will assess the impact on nasopharyngeal carriage, safety and immunogenicity of GSK Biologicals' pneumococcal vaccine 2189242A given as a 3-dose vaccination course and co-administered with other routine paediatric…
- Trial name
- NCT01262872
- Testing
- Pneumococcal vaccine GSK 2189242A (LD formulation 1), Pneumococcal vaccine GSK 2189242A (HD formulation 2), Synflorix™
- Where
- The Gambia
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pneumonia, Pneumococcal, Invasive Pneumococcal Disease
An Epidemiological Survey to Establish the Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Older 18 Years
Pneumococcal conjugate vaccine was added to the National Immunization Program in Russia in 2014 which could affect the changes in pneumococcal serotypes in growing population.
- Conditions
- Pneumonia, Pneumococcal, Invasive Pneumococcal Disease, Acute Otitis Media
- Trial name
- SPECTRUM (NCT04464291)
- Testing
- Detection of Streptococcus pneumoniae strains
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- The Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC)
Meningitis, Septicaemia
Understanding Pneumococcal Carriage and Disease
Pneumococcus is a bacteria that causes disease of the respiratory tract (pneumonia and middle ear infections), blood poisoning, and meningitis. It is frequently carried by people in back of the throat without symptoms.
- Conditions
- Meningitis, Septicaemia, Pneumonia
- Trial name
- NCT01996007
- Where
- United Kingdom
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nasopharyngeal Carriage of Streptococcus Pneumoniae
Effects of Pneumococcal Vaccine on Nasopharyngeal Carriage
The purpose of this study is to assess the direct effects of the ten-valent pneumococcal conjugate vaccine administered to infants on nasopharyngeal carriage at 3 to 5 years of age.
- Trial name
- NCT01925222
- Where
- Finland
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- Arto Palmu
Streptococcus Pneumoniae, Nasopharyngeal Carriage
Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers
Rationale In Belgium, a unique situation exists for two reasons: on the one hand, the pneumococcal conjugate vaccine (PCV) program, which started in 2007, has quickly reached high coverage in infants: 3-dose coverage rose from 89…
- Trial name
- NCT02888457
- Testing
- Nasopharyngeal sampling with a swab
- Where
- Belgium
- Volunteers
- 2,817 people, healthy volunteers welcome
- Sponsor
- Pierre Van Damme
Otitis Media, Otitis Media With Effusion
Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media
The aim of this study is to assess in France the impact of Prevenar on the possible evolution of the pneumococcal serotypes distribution and antibiotic resistance in NP samples of children with AOM.
- Conditions
- Otitis Media, Otitis Media With Effusion, Pneumococcal Infections
- Trial name
- NCT00195611
- Testing
- Prevenar
- Where
- 35 sites in France
- Volunteers
- 3,293 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pneumococcal Infections
Indirect Effects of Pneumococcal Vaccine on Nasopharyngeal Carriage
The purpose of this study is to assess the indirect effects of a pneumococcal conjugate vaccine administered to infants on vaccinees' elder non-vaccinated siblings aged 3 to 7 years.
- Trial name
- FinIPcarr (NCT01311024)
- Testing
- PCV GSK1024850A, hepatitis B vaccine or hepatitis A vaccine
- Where
- Finland
- Volunteers
- 2,341 people, healthy volunteers welcome
- Sponsor
- Arto Palmu
Childhood Pneumonia, Pneumococcal Carriage
The Study of Chest Infections in Infants Living in a Refugee Camp on the Thai-Burmese Border
This study will follow 1000 refugee infants from birth for two years. The aim of the study is to better understand why some children develop infections caused by the bacterium Streptococcus pneumoniae whilst others merely carry…
- Trial name
- ARI (NCT00894764)
- Where
- 2 sites in Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Antibiotic Use, Carriage of Antibiotic Resistant Pathogens
Israeli Judicious Antibiotic Prescription Study
This study aims to implement judicious antibiotic prescription habits to primary care pediatricians using a multifacet educational intervention and assess two main outcomes: 1) Direct outcome - prescription rates of the…
- Trial name
- IJAP (NCT01187758)
- Testing
- Workshops and focus group meetings
- Volunteers
- 5,700 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pneumonia
Pneumonia Research and Vaccine Impact League
The leading cause of severe respiratory disease and death in young children is Streptococcus pneumoniae (pneumococcus). An estimated one-fifth of global childhood pneumococcal-related deaths occurred in India.
- Trial name
- PREVAIL (NCT03900520)
- Where
- India
- Volunteers
- 6,004 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Nasopharyngeal Carriage, Children, Only
Nasopharyngeal Carriage of S. Pneumoniae
This nasopharyngeal (NP) carriage surveillance study was requested by the European Agency for the Evaluation of Medicinal Products as a post-licensing commitment to determine whether the use of the pneumococcal conjugate vaccines…
- Conditions
- Nasopharyngeal Carriage, Children, Only, Antibiotic Resistant Strain
- Trial name
- NCT04460313
- Testing
- nasopharyngeal sample (mandatory), Stools collection or anorectal swab samples (optional), nasopharyngeal sample (optional)
- Where
- France
- Volunteers
- 29,360 people, healthy volunteers welcome
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Pneumococcal Infections
Pneumococcal Vaccination of Fiji Infants
Pneumonia is the most common reason for admission of Fijian children to hospitals. The most common germ causing pneumonia is "streptococcus pneumoniae." It is a common cause of meningitis (infection around the brain and spinal…
- Trial name
- NCT00170612
- Testing
- Pneumovax 23, Prevnar
- Where
- Fiji
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Pneumococcal Disease
Nasopharyngeal Carriage Study in Healthy Kenyan Toddlers
This study evaluated the change in nasopharyngeal carriage (NPC) of Streptococcus pneumoniae (SPn), hypothesizing that it would be reduced post-vaccination with Streptococcus pneumoniae whole cell vaccine with aluminum hydroxide…
- Trial name
- NCT02146365
- Where
- Kenya
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- PATH
Infections, Streptococcal
Long-term Follow-up Study of Children Previously Primed With GSK Pneumococcal Vaccine (GSK1024850A) and of Unprimed Children
The objective of this study is to evaluate the immune memory through the administration of an additional dose of GSK Biologicals' pneumococcal conjugate vaccine GSK1024850A, the antibody persistence and long-term effect on…
- Trial name
- NCT00950833
- Testing
- Pneumococcal vaccine GSK1024850A
- Where
- 10 sites in Czechia
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline