Clinical trials: Pleural Pleurisy Effusion
Tuberculous Pleurisy
Drainage of Tuberculous Pleural Effusions
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to…
- Trial name
- NCT00524147
- Testing
- Pigtail drainage
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Taipei Medical University Hospital
Pleural Effusion
Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Background: Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps.
- Trial name
- NCT04683419
- Testing
- Modified Thoracoscopic pleural Cryobiopsy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Pleurisy With Effusion
A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions
Rigid thoracoscopy is an established procedure for the performance of pleural biopsies for undiagnosed pleural effusions. The semirigid thoracoscope is a relatively new instrument designed for the same purpose which is claimed to…
- Trial name
- RISE (NCT01726556)
- Testing
- Rigid thoracoscope (Richard Wolf GmbH, Knittlingen, Germany), Semirigid thoracoscope (model LTF-160Y1, Olympus, Japan)
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pleural Effusion, Tuberculosis, Pleural
TBP Survey Among Respiratory Physicians
Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common…
- Trial name
- NCT06390969
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Tuberculosis, Pleural
Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA
Tuberculosis (TB) is one of the major global health threats and is the second leading infectious cause of death after COVID-19 in 2022.
- Trial name
- MYDNITE-2 (NCT06439810)
- Testing
- Mycobacterium tuberculosis (MTB) cell-free DNA (cfDNA)
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Effusion
Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion
Exudative pleural effusion (EPE) presents a diagnostic challenge, requiring accurate biomarkers to predict outcomes and guide treatment.
- Trial name
- NCT07003204
- Testing
- medical thoracoscopy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Pleural Effusion, Chronic Kidney Disease
Pleural Effusion Types in Chronic Kidney Disease
The purpose of this observational study is to understand the causes of pleural effusion (a buildup of fluid around the lungs) in patients with advanced Chronic Kidney Disease (CKD Stages 3 to 5).
- Trial name
- NCT07547852
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pleural Effusion, Pleural Effusion, Malignant
Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap
Patients planned to undergo a pleural tap will get verbal explanation or watch a personalized guidance video in addition to verbal explanation.
- Conditions
- Pleural Effusion, Pleural Effusion, Malignant, Pleural Pleurisy Effusion
- Trial name
- NCT04254445
- Testing
- Personalized training video
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- GistMed Ltd.
Pleural Effusion, Pleurisy
Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy
This is a prospective study to assess the yield of pleural biopsy obtained with the routine flexible thoracoscopic biopsy forceps versus that obtained with a flexible cryoprobe during semirigid thoracoscopy
- Conditions
- Pleural Effusion, Pleurisy, Tuberculosis, Metastatic Malignancy
- Trial name
- COFFEE (NCT02500277)
- Testing
- Cryoprobe pleural biopsy first, Flexible forceps biopsy first
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Tuberculosis, Tuberculous Pleurisy
Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion
Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to be a tumor suppressive gene.
- Conditions
- Tuberculosis, Tuberculous Pleurisy, Malignant Pleural Effusion, Empyema
- Trial name
- NCT00313066
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
To Investigate Diagnostic Aid of the Inflammation and Apoptosis-associated Markers and Apoptosis Pattern of PE Neutrophil for Tuberculous Pleurisy
Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy
1. To investigate the difference of PE inflammation/apoptosis-associated markers between TB pleurisy and non-TB pleurisy 2. To investigate the difference of neutrophil apoptosis in exudative PE between TB pleurisy and non-TB…
- Trial name
- NCT01685099
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion, Pleural Diseases
Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy
The aim of this study is to compare the rigid thoracoscopy with CT-guided pleural needle biopsy by the diagnostic efficacy and safety in patients with pleural effusion.
- Trial name
- NCT00720954
- Testing
- Ct-guided pleural needle biopsy, Thoracoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Eskisehir Osmangazi University
Pleural Effusion
Ultrasound-guided Pigtail Catheter Versus Intercostal Tube Drainage of Non-traumatic Exudative Pleural Effusion
Primary Aims: To compare the performance of pigtail catheter to that of ICT in drainage of pleural effusion of medical aetiology regarding: 1. Various complications(mainly wound pain) that result from either therapeutic approach.
- Trial name
- NCT06099054
- Testing
- Pigtail catheter, Intercostal tube
- Volunteers
- 80 people
- Sponsor
- Assiut University
Pleural Effusion, Exudative Pleuritis
Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis
Research project objectives. The project includes eight research hypotheses and eight corresponding study objectives. The most relevant objectives are: Analysis of lung function and gas exchange parameters in relation to the…
- Trial name
- NCT02192138
- Testing
- Therapeutic thoracentesis, Pleural catheter, Pleural manometer
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Pleural Effusion, Pleurisy
Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy
This is a prospective study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections in patients undergoing medical thoracoscopy.
- Conditions
- Pleural Effusion, Pleurisy, Empyema
- Trial name
- APT (NCT02446782)
- Testing
- Cefazolin, saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Malignant Pleural Effusion, Exudative Pleural Effusion
Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura
The research group will investigate the diagnostic effect of early introduction of ultrasound guided pleural biopsy in the work-up of patients with one-sided pleural effusion, suspected of malignant pleural effusion.
- Trial name
- NCT04236037
- Testing
- ultrasound-guided pleural biopsy, Thoracentesis
- Where
- 2 sites in Denmark
- Volunteers
- 5 people
- Sponsor
- Naestved Hospital
Pleural Effusion Due to Another Disorder (Disorder)
Natural History of Nonspecific Pleuritis Diagnosed After Video-assisted-thoracoscopic-surgery
The investigators want to determine the incidence of malignant disease, type of malignant disease and overall survival in patients diagnosed with NSP after VATS.
- Trial name
- NCT03270228
- Testing
- Nonspecific pleuritis after VATS thoracoscopy
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- Naestved Hospital
Tuberculosis, Pleural
MTB cfDNA Levels in TBP
Tuberculous pleuritis (TBP) is the most common manifestation of extrapulmonary TB. Its diagnosis is challenging due to the low sensitivity of mycobacterial culture from the pleural fluid and the need for invasive pleural biopsy.
- Trial name
- MYDNITE (NCT05397730)
- Testing
- Mycobacterium tuberculosis (MTB) cell-free DNA (cf-DNA)
- Where
- Hong Kong
- Volunteers
- 329 people
- Sponsor
- Chinese University of Hong Kong
Pleural Effusion, Transudative Pleural Effusion
Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions
Pleural effusion is a condition where excess fluid builds up in the space between the lungs and the chest wall. To properly treat this condition, doctors must determine if the fluid is a "transudate" (usually resulting from…
- Conditions
- Pleural Effusion, Transudative Pleural Effusion, Exudative Pleural Effusion
- Trial name
- NCT07513909
- Volunteers
- 90 people
- Sponsor
- Assiut University
Tuberculous Pleurisy
Corticosteroids in the Treatment of Tuberculous Pleurisy
Tuberculous pleurisy is associated with inflammation and fibrosis. Adjunctive corticosteroids are used for tuberculous pleurisy because their anti-inflammatory effect is thought to minimise pleural reactivity and thereby reduce…
- Trial name
- NCT00338793
- Testing
- prednisolone
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Guangxi Medical University