Clinical trials: Pleural Effusion
Postoperative Pulmonary Dysfunction
Different Modes of Ventilation During Cardiopulmonary Bypass
66 patients divided into 3 groups with different modes of ventilation.
- Trial name
- NCT03824301
- Testing
- Volume controlled ventilation, Pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Malignant Pleural Effusion, Indwelling Pleural Catheter
Malignant Pleural Effusions: Evaluating the psYchosocial Impact of Indwelling Pleural Catheters on Patients
The purpose of this study is to better understand the impact that Indwelling Pleural Catheters have on patients with malignant pleural effusions from a psychosocial point of view.
- Trial name
- MY-IPC (NCT05372055)
- Testing
- Semi-structure interviews
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Tuberculosis, Pleural Effusion
Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis.
- Trial name
- NCT01560078
- Where
- India
- Volunteers
- 360 people
- Sponsor
- All India Institute of Medical Sciences
Pneumothorax, Pleural Effusion
Drainage Amount for Removal of Thoracostomy Tube
The purpose of this study is to determine whether chest tubes can be safely removed without considering how much fluid is draining through the tube.
- Trial name
- DARTT (NCT00575198)
- Testing
- No drainage threshold, Drainage <2 mL/kg
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of California, Davis
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Tuberculous Pleurisy
Drainage of Tuberculous Pleural Effusions
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to…
- Trial name
- NCT00524147
- Testing
- Pigtail drainage
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Taipei Medical University Hospital
Lung Cancer
Pleural Catheters Versus Thoracoscopic Pleurodesis
The goal of this clinical research study is to compare 2 different methods for treating a pleural effusion. Researchers also want to learn how the treatment you receive effects your quality of life (your ability to do the things…
- Trial name
- NCT01117740
- Testing
- MDASI Questionnaire
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion
Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Background: Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps.
- Trial name
- NCT04683419
- Testing
- Modified Thoracoscopic pleural Cryobiopsy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Peritoneal Dialysis, Peritoneal Dialysis (PD)
Iodine Starch Test Use in Pleuroperitoneal Leak
This is a study to see how a simple test can be used to check if fluid in the chest cavity contains starch. Some people with kidney failure have dialysis treatment by putting fluid in the tummy cavity, and sometimes the fluid can…
- Conditions
- Peritoneal Dialysis, Peritoneal Dialysis (PD), Pleural Cavity Effusion, Hydrothorax
- Trial name
- PIT-PLPD (NCT07857564)
- Testing
- Iodine tincture
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pleural Effusion
Virtual Reality for Satisfaction and Tolerability During Intercostal Chest Drain Insertion: A Headset-Based Randomized Controlled Trial
Intercostal chest drain (ICC) insertion is a common procedure done worldwide to treat and diagnose pleural disease. It is used to evacuate fluid, blood, or air in the cavity from a myriad of causes namely pleural effusions of…
- Trial name
- VR-STICH (NCT06247800)
- Testing
- Virtual Reality Device, Without virtual reality
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- National University of Malaysia
Pleural Effusion, Pleural Effusion, Malignant
Multiple Biomarkers in Undiagnosed Pleural Effusion
The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions.
- Trial name
- NCT00316134
- Testing
- Procedure/Surgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fujirebio Diagnostics, Inc.
Lung Cancer
Sonography After Thoracic Surgery (SATS)
Lung cancer remains the leading cause of mortality from malignant diseases in both men and women worldwide. Following thoracic surgery and pulmonary resection, patients have a surgically induced pneumothorax / hydro-hemothorax…
- Trial name
- NCT01152463
- Testing
- thoracic ultrasound
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lung Cancer, Malignancy
Immune- and Microenvironment- Proteogenomics Profiling for Classifying Lung Cancer Patients
The excessive accumulation of fluid between the membranes surrounding the lung, a clinical condition commonly referred to as "pleural effusion", is caused by one of three factors: increased production of pleural fluid, decreased…
- Trial name
- NCT04887545
- Testing
- Proteomics analysis of pleural effusion
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Universidade Nova de Lisboa
Malignant Mesothelioma, Metastatic Cancer
Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma
RATIONALE: Video-assisted surgery to remove part of the tissue layer covering the inside of the chest cavity may be effective in treating pleural effusion and cause less damage to normal tissue.
- Trial name
- MesoVATS (NCT00821860)
- Testing
- talc, therapeutic thoracoscopy, therapeutic videothoracoscopy
- Where
- 5 sites in United Kingdom
- Volunteers
- 196 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Pleural Effusion, Pneumothorax
Ballooned Intercostal Drain Trial
This study is designed to assess whether a new type of chest drain reduces the number of drains that fall out of or are accidentally removed from the chest cavity (usually requiring another drain to be inserted), without causing…
- Trial name
- NCT03000504
- Testing
- Ballooned intercostal drain
- Where
- 3 sites in United Kingdom
- Volunteers
- 178 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Stage IIIB Non-small Cell Lung Cancer With Pleural Effusion, Stage IV Non-small Cell Lung Cancer
First Line Study of Tamibarotene in Combination for Advanced Non-Small Cell Lung Cancer
The goal of this study is to determine the progression-free survival and objective response rate in subjects with either stage IIIB with pleural effusion NSCLC or stage IV NSCLC who are treated with up to six cycles of paclitaxel…
- Trial name
- NCT01337154
- Testing
- Tamibarotene
- Where
- 26 sites in United States, Bulgaria and 4 more
- Volunteers
- 140 people
- Sponsor
- CytRx
Pleurisy With Effusion
A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions
Rigid thoracoscopy is an established procedure for the performance of pleural biopsies for undiagnosed pleural effusions. The semirigid thoracoscope is a relatively new instrument designed for the same purpose which is claimed to…
- Trial name
- RISE (NCT01726556)
- Testing
- Rigid thoracoscope (Richard Wolf GmbH, Knittlingen, Germany), Semirigid thoracoscope (model LTF-160Y1, Olympus, Japan)
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Locally Advanced Non Small-Cell Lung Canger
Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer
Nitroglycerin will increase the effectiveness of treatment with induction chemotherapy and concurrent chemo-radiotherapy by reducing chemo-radio resistance through an increased oxygen pressure in tumoral tissue.
- Trial name
- NCT00886405
- Testing
- Transdermal nitroglycerin
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- National Institute of Cancerología
Thoracoscopy, Pleural Effusion Disorder
Visual Assessment vs ROSE in Diagnosing Pleural Effusion Using Medical Thoracoscopy
The goal of this observational diagnostic study is to find how well two evaluation methods used during medical thoracoscopy can help identify whether pleural disease is malignant or benign.
- Trial name
- NCT07286045
- Testing
- Medical thoracoscopy
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Pleural Effusion
Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy
The objective of the study is to determine the safety and efficacy of TNK infusion for the treatment of loculated pleural effusions in patients with known malignancy compared to normal saline infusion.
- Trial name
- NCT01580618
- Testing
- normal saline, TNK (Tenecteplase)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente