Clinical trials: Platelet Aggregation Inhibition
Acute Coronary Syndrome, Platelet Function
Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis
Introduction: Platelet aggregation plays an important role in ischemic complications in patients undergoing to percutaneous coronary intervention (PCI).
- Trial name
- SAMPA (NCT02215993)
- Testing
- Prasugrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Acute Coronary Syndrome, STEMI
Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg in Elderly Patients With ACS
Elderly individuals are increasingly represented among patients with acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) with aspirin and an oral P2Y12 receptor inhibitor has an established role in the prevention of…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Coronary Artery Disease
- Trial name
- PlinytheElder (NCT04739384)
- Testing
- Ticagrelor 90mg, Ticagrelor 60 mg
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Non ST Segment Elevation Acute Coronary Syndrome
Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS
Ticagrelor is an oral, reversibly-binding, direct-acting P2Y12 receptor antagonist used clinically for the prevention of atherothrombotic events in patients with acute coronary syndromes (ACS).
- Trial name
- NCT02415803
- Testing
- low-dose ticagrelor, conventional-dose ticagrelor, Clopidogrel
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Patients With Acute Coronary Syndrome
Prasugrel Versus Clopidogrel in Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Background: Both prasugrel and clopidogrel are prescribed drugs which compete as platelet inhibitors in patients with acute coronary syndrome (ACS).
- Trial name
- NCT01090336
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Heidelberg University
Breast Neoplasms
A Study of the Effects of Inhibiting Platelet Function on Circulating Cancer Cells in Breast Cancer Patients
The purpose of this study is to determine the effects of Plavix and aspirin in women with metastatic breast cancer.
- Trial name
- NCT00263211
- Testing
- Plavix, Aspirin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Acute Myocardial Infarction
Effect of the Repeated Loading Dose of Clopidogrel and High Dose of Clopidogrel Continuous Therapy on the Platelet Aggregation Inhibition in Patients With Myocardial Infarction Undergoing Interventional Treatment.
REL-0609 trial's hypothesis is that repeated loading doses of clopidogrel (600 mg) administration in addition to high dose of clopidogrel continuous therapy (150 mg/day) results in higher inhibition of the platelets' aggregation…
- Trial name
- REL-0609 (NCT01636180)
- Testing
- Clopidogrel
- Where
- Poland
- Sponsor
- Fundacja Ośrodek Badań Medycznych
Systolic Heart Failure
Platelet Inhibition in Patients With Systolic Heart Failure
The investigators aim to determine if patients with systolic heart failure treated with prasugrel achieve greater platelet inhibition compared to those treated with clopidogrel.
- Trial name
- NCT01765400
- Testing
- Prasugrel 10 mg daily x 2 weeks, Clopidogrel 75 mg daily x 2 weeks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Hypercholesterolemia, Thrombosis
The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: a Metabolic Inhibition of Hepatic Cytochrome P450-3A
The objective of this study is to determine if the action of the drug called clopidogrel, that you will start taking, will be decreased by another drug called atorvastatin, that you will also start taking.
- Trial name
- NCT00004564
- Testing
- Clopidogrel, Atorvastatin
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Cardiovascular Diseases
Effect of Ingesting a Tomato Pomace Extract on Platelet Aggregation
This study evaluates the acute and longer term effects of a tomato pomace extract on platelet aggregation in health subjects.
- Trial name
- Tomasa (NCT02986165)
- Testing
- Low dose pomace extract, High dose pomace extract
- Where
- Chile
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centro de Estudios en Alimentos Procesados
Acute Myocardial Infarction
Daily Variability of Platelet Aggregation in Patients With Myocardial Infarction Treated With Prasugrel and Ticagrelor
The aim of this study is to compare circadian variability of antiplatelet effect of prasugrel and ticagrelor maintenance doses during the initial days after acute myocardial infarction.
- Trial name
- DRAGON (NCT03454841)
- Testing
- Prasugrel, Ticagrelor
- Where
- 2 sites in Poland
- Volunteers
- 73 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Congenital Heart Defects, Blood Platelet Disorders
Platelet Aggregation Inhibition in Children on Clopidogrel (PICOLO)
PICOLO is a double blind placebo controlled phase II dose ranging, dose escalating study in patients of Blalock-Taussig age categories (neonates and infants/toddlers), to determine the dose providing inhibition of platelet…
- Trial name
- NCT00115375
- Testing
- Clopidogrel (SR25990)
- Where
- 6 sites in United States, Belgium and 4 more
- Volunteers
- 92 people
- Sponsor
- Sanofi
Inhibition on Platelet Aggregation
Study to See if Platelet Transfusion Stop or Lessen the Effect of the Drug on Platelets
Study to see if platelet transfusion stop or lessen the effect of the drug on platelets
- Trial name
- NCT01744288
- Testing
- Ticagrelor, Clopidogrel, ASA
- Where
- United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Myocardial Infarction
A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Heart Attack
The goal of this study is to find out how fast a drug called selatogrel (ACT-246475) can prevent platelets from binding together. This study will also help to find out more about the safety of this new drug.
- Trial name
- NCT03487445
- Testing
- Selatogrel 8 mg, Selatogrel 16 mg
- Where
- 6 sites in Belgium, Israel and 1 more
- Volunteers
- 48 people
- Sponsor
- Viatris Innovation GmbH
Pharmacodynamics
Comparative Pharmacodynamics and Pharmacokinetics Study of Generic and Reference Clopidogrel Products
The purpose of this study is to compare the pharmacodynamic effect of clopidogrel on the platelet inhibition and the pharmacokinetic profiles of clopidogrel carboxylic acid metabolite between generic and reference clopidogrel…
- Trial name
- NCT02010632
- Testing
- Generic clopidogrel product Apolets®, Original clopidogrel product Plavix®
- Where
- Thailand
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Low HDL Cholesterol
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals
This is a study of HDL function in healthy individuals classified in three groups according to their HDL-cholesterol levels (Low HDL-C, Intermediate HDl-C and High HDL-C), with the purpose of investigating which characteristics…
- Trial name
- NCT02106013
- Where
- Brazil
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Thrombosis, Arterial Occlusive Diseases
Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization
The goal of this clinical trial is to learn if a blood clotting test called thromboelastography with platelet mapping (TEG-PM) can guide blood-thinning medication decisions in adults more than 60 years and older with peripheral…
- Conditions
- Thrombosis, Arterial Occlusive Diseases, Thromboelastography (TEG), Peripheral Arterial Disease(PAD)
- Trial name
- TARGET (NCT07597239)
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Pneumonia, Community Acquired Pneumonia
Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor
The hypothesis to be tested is that ticagrelor (Brilinta™) will reduce platelet activation and markers of inflammation in patients with pneumonia.
- Conditions
- Pneumonia, Community Acquired Pneumonia, Hospital Acquired Pneumonia, Acute Lung Injury
- Trial name
- XANTHIPPE (NCT01883869)
- Testing
- ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Kentucky
Thrombosis
The Association Between Platelet Inhibition and Perioperative Major Adverse Cardiac Events In Post-Percutaneous Coronary Intervention (PCI) Patients Undergoing Non-Cardiac Surgery
This prospective, multicentre, observational study aims to test pre-operative platelet function when taking anti-platelet medications.
- Trial name
- NCT01707459
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- University Health Network, Toronto
Seasonal Allergic Rhinitis
Rupatifen Fumarate Capsules in Patients With Seasonal Allergic Rhinitis
This Phase Ⅲ randomized, double-blind, active- and placebo-controlled trial aims to assess the efficacy and safety of Rupatifen Fumarate Capsules for seasonal allergic rhinitis.
- Trial name
- NCT07711262
- Testing
- Rupatifen Fumarate Capsules, Rupatadine Fumarate Tablets
- Where
- 18 sites in China
- Volunteers
- 550 people
- Sponsor
- Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd.
Coronary Artery Disease
The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY)
With potent analgesic properties, perceived hemodynamic benefits and limited alternatives, opiates are the analgesic mainstay for acute coronary syndrome (ACS) patients reporting peri-procedural pain or nitrate-resistant chest…
- Trial name
- PACIFY (NCT02683707)
- Testing
- Removal of Fentanyl from peri-procedural analgesia, Fentanyl, Lidocaine
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Johns Hopkins University