Clinical trials: Placenta
Placenta; Implantation
MRI Screening of Placenta Adhesion Abnormalities
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during…
- Trial name
- DIANE (NCT04328532)
- Testing
- MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Placenta Accreta Spectrum
Diagnostic Trial of a Vision Transformer-Based Ultrasound AI Model for Placenta Accreta Spectrum
This study develops an end-to-end Vision Transformer (ViT)-based artificial intelligence system for ultrasound-based diagnosis of placenta accreta spectrum (PAS), aiming to improve the accuracy and efficiency of prenatal…
- Trial name
- NCT07643090
- Testing
- Vision Transformer-Based End-to-End Ultrasound Artificial Intelligence Model
- Where
- China
- Volunteers
- 561 people
- Sponsor
- FANG HE
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
Database of Monochorionic Pregnancies
The purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Twin; Complicating Pregnancy, Twin to Twin Transfusion Syndrome
- Trial name
- NCT05543499
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Miami
Placenta Percreta, Third Trimester, Placenta Previa
Placenta Previa and Placenta Percreta Patients During the Third Trimester
Placenta previa can cause a risk of severe bleeding during labor. Placenta previa is usually classified into four different types: total, partial, marginal and asymptomatic.
- Trial name
- NCT06849349
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Retained Placenta
Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination
Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion.
- Trial name
- ANDDROID (NCT02969447)
- Testing
- Administration of 10 units of intra venous oxytocin after fetal expulsion
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Bordeaux
Placenta Accreta Spectrum
Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders
This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality.
- Trial name
- U-PRESERVE (NCT06512181)
- Testing
- Conservative/Expectant Management
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Placenta Accreta Spectrum, Abnormal Placentation
Effect of Methylene Blue Bladder Instillation on Urinary Tract Injuries During Cesarean Hysterectomy for Placenta Accreta Spectrum
This prospective cohort study aims to evaluate whether preoperative bladder filling with methylene blue dye can reduce the incidence of urinary tract injuries during cesarean hysterectomy in patients diagnosed with placenta…
- Conditions
- Placenta Accreta Spectrum, Abnormal Placentation, Cesarean Hysterectomy, Urinary Tract Injury
- Trial name
- NCT07129135
- Testing
- The bladder was filled with 300 ml diluted methylene blue (in normal saline) via Foley's catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Usama Ahmed Elsaeed Salem, MD
Placenta Accreta Spectrum
High vs. Low Segmental Hysterotomy: Impact on Uterine Wall Defects Post-Cesarean
The purpose of this clinical trial is to compare the incidence of defects in the uterine wall at the site of the scar (niche) and surgical complications when using high-segment versus low-segment hysterotomy, with both…
- Trial name
- HISEAL (NCT06620432)
- Testing
- Low segment hysterotomy, High segment hysterotomy, Crossed hysterorrhaphy
- Where
- Colombia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinica Valle del Lili
Twin Monochorionic Diamniotic Placenta
Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
The purpose of this study is to evaluate the safety and efficacy of the investigational fetoscopes used in patients undergoing fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic pregnancies.
- Trial name
- NCT06022510
- Testing
- Fetoscopy Sets for Anterior and Posterior Placentas
- Where
- United States
- Sponsor
- Michael A Belfort
Placenta Accreta
Use of ROTEM Intraoperatively in Women With Placenta Accreta
This study evaluates the use of rapid tests for hematocrit and clotting function in women undergoing surgery for placenta accreta.
- Trial name
- ROTEM (NCT02729974)
- Testing
- ROTEM, standard treatment
- Volunteers
- 32 people
- Sponsor
- University of Utah
Placenta Accreta
Conservative Management for PAS Pilot
Conservative in situ management is a promising alternative treatment to hysterectomy for patients with placenta accreta spectrum and may be safer and preferable for some patients.
- Trial name
- NCT05139498
- Testing
- Conservative management for placenta accreta spectrum (PAS), Cesarean hysterectomy for placenta accreta spectrum (PAS)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Placenta Accreta Spectrum
Conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique With or Without Hayman Sutures
This study evaluates whether adding Hayman sutures in the conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique reduces intraoperative blood loss and improves outcomes
- Trial name
- NCT07519993
- Testing
- Kasr Al-Ainy Technique Alone, Kasr Al-Ainy Technique + Hayman Sutures
- Volunteers
- 48 people
- Sponsor
- Cairo University
Preterm Premature Rupture of Membrane, Placenta Diseases
Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of Membrane
Although preterm premature rupture of membranes (PPROM) is one of the most common causes of preterm birth, it can also lead to serious maternal and neonatal complications.
- Trial name
- NCT06639919
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Placental Thickness, PLACENTA VOLUME
Placental Thickness -To-Fetal Weight Ratio as a Predictor of Adverse Pregnancy Outcome
The aim of this study is to evaluate the placental thickness-to-fetal weight ratio as a predictor of adverse pregnancy outcomes.
- Trial name
- NCT07467148
- Volunteers
- 70 people
- Sponsor
- Radia Atef Elzokm
Placenta Accreta / Percreta
Clinical Situations at High Risk of Placenta Accreta / Percreta
The purpose of this study is to identify what factors -either individual or related to the type of management received- influence the maternal outcomes in pregnant women at high risk for placenta accreta i.e , women with placenta…
- Trial name
- Paccreta (NCT02010229)
- Where
- France
- Volunteers
- 674 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dysbiosis, Inflammation Gum
Microbiome Alterations With Xylitol (MAX) in Pregnancy
The purpose of this study is to understand if chewing xylitol-gum initiated before 20 weeks of pregnancy and continued until delivery affects the bacteria that are found in the oral and vaginal cavities, signs of inflammation…
- Conditions
- Dysbiosis, Inflammation Gum, Placenta-mediated Pregnancy Complications, Microbioata
- Trial name
- MAX (NCT06329596)
- Testing
- Xylitol gum, Sorbitol gum
- Where
- Malawi
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Placenta Accreta Spectrum, Placenta Accreta
Evaluation of Cervical Invasion and Length in Placenta Accreta Patients
Placenta accreta spectrum (PAS), also called morbidly adherent placenta, is a serious pregnancy problem where the placenta attaches too deeply to the uterus wall and does not come out normally after birth.
- Conditions
- Placenta Accreta Spectrum, Placenta Accreta, Placenta Previa
- Trial name
- NCT07452185
- Volunteers
- 200 people
- Sponsor
- Sohag University
High Risk Pregnancy, Congenital Heart Disease
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome.
- Conditions
- High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta
- Trial name
- NCT03775954
- Testing
- Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Postpartum Hemorrhage (PPH), Postpartum Hemorrhage Third Stage of Labour Retained Placenta
Intra-Umbilical Vein Oxytocin Injection as an Adjunct to Active Management of the Third Stage of Labour
This randomized controlled clinical trial evaluates the effect of umbilical vein injection of oxytocin given in addition to routine active management of the third stage of labour.
- Trial name
- NCT07436286
- Testing
- Oxytocin
- Where
- Nigeria
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Dangana Zakari Adeka
Placenta Accreta Spectrum, Placenta Previa
Maternal Serum Adropin in Placenta Accreta Spectrum
Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for…
- Trial name
- Adropin (NCT07421180)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital