Placenta Accreta SpectrumNCT07519993
Conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique With or Without Hayman Sutures
A study testing Kasr Al-Ainy Technique Alone and Kasr Al-Ainy Technique + Hayman Sutures in people with Placenta Accreta Spectrum, run by Cairo University.
Trial summary
This study evaluates whether adding Hayman sutures in the conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique reduces intraoperative blood loss and improves outcomes Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Placenta Accreta Spectrum
- What is being tested?
- Kasr Al-Ainy Technique Alone and Kasr Al-Ainy Technique + Hayman Sutures
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- No sites listed yet
- Study dates
- 5 Apr 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Age 18-40 years
- Antenatal PAS diagnosis confirmed by TAS/TVS/Doppler
- Eligible for conservative Kasr Al-Ainy surgery
- Singleton pregnancy
- Written informed consent
Who cannot join
- Multiple pregnancy
- Uterine fibroids
- Previous cesarean myomectomy
- Cervical accreta
- Extensive parametrial or bladder invasion requiring hysterectomy
- Known coagulopathy or uncorrected bleeding disorder.
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- Severe medical comorbidities rendering the patient unfit for major surgery under general anesthesia (e.g., severe cardiac or pulmonary disease)
- Medical disorders as HTN and DM
- Patient refusal
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
This study evaluates whether adding Hayman sutures in the conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique reduces intraoperative blood loss and improves outcomes
- Conditions
- Placenta Accreta Spectrum
- Being tested
- Kasr Al-Ainy Technique Alone, Kasr Al-Ainy Technique + Hayman Sutures
- Medical subject headings
- Placenta Accreta
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Kasr Al-Ainy Technique AloneProcedure or surgery
- Vascular Ligation: Bilateral uterine artery tying at high and low levels.
- Compression Sutures: Anterior and posterior cervicovaginal stitches for hemostasis.
- Segmental Resection: Excision of invaded myometrium and placental tissue.
- Dual-Layer Repair: Myometrial approximation followed by reinforcing imbricating sutures.
- Final Hemostasis: Confirmation of bleeding control prior to abdominal closure.
Kasr Al-Ainy Technique + Hayman SuturesProcedure or surgery
- Vascular Ligation: Bilateral uterine artery tying at high and low levels.
- Compression Sutures: Anterior and posterior cervicovaginal stitches for hemostasis.
- Segmental Resection: Excision of invaded myometrium and placental tissue.
- Dual-Layer Repair: Myometrial approximation followed by reinforcing imbricating sutures.
- Final Hemostasis: Confirmation of bleeding control prior to abdominal closure.
- Application of Hayman vertical compression sutures
| Study group | Role | What they receive |
|---|---|---|
| Kasr Al-Ainy Technique Alone | Active comparator | Not described Receives: Procedure: Kasr Al-Ainy Technique Alone |
| Kasr Al-Ainy Technique + Hayman Sutures | Experimental | Not described Receives: Procedure: Kasr Al-Ainy Technique + Hayman Sutures |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intra-operative estimated blood loss
Measured: During operation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2026
- Study start5 Apr 2026 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Placenta Accreta SpectrumStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abdalla Mousa, Cairo University
- Investigators
- Emad Salah, M.D., Principal investigator, Cairo UniversityMona Sedik, M.D., Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07519993
- Sponsor's protocol ID
- MS-636-2025
- Status last verified
- Apr 2026
- First submitted
- 2 Apr 2026
- Last updated
- 9 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique With or Without Hayman Sutures
- ClinicalTrials.gov ID
- NCT07519993
- Acronym / sponsor ID
- MS-636-2025
- Conditions
- Placenta Accreta Spectrum
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 5 Apr 2026 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 9 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates whether adding Hayman sutures in the conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique reduces intraoperative blood loss and improves outcomes
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Kasr Al-Ainy Technique Alone | Active comparator | Procedure: Kasr Al-Ainy Technique Alone |
| Kasr Al-Ainy Technique + Hayman Sutures | Experimental | Procedure: Kasr Al-Ainy Technique + Hayman Sutures |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age 18-40 years
- Antenatal PAS diagnosis confirmed by TAS/TVS/Doppler
- Eligible for conservative Kasr Al-Ainy surgery
- Singleton pregnancy
- Written informed consent
Key exclusion criteria (9 listed)
- Multiple pregnancy
- Uterine fibroids
- Previous cesarean myomectomy
- Cervical accreta
- Extensive parametrial or bladder invasion requiring hysterectomy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Kasr Al-Ainy Technique Alone1. Vascular Ligation: Bilateral uterine artery tying at high and low levels. 2. Compression Sutures: Anterior and posterior cervicovaginal stitches for hemostasis. 3. Segmental Resection: Excision of invaded myometrium and placental tissue. 4. Dual-Layer Repair: Myometrial approximation followed by reinforcing imbricating sutures. 5. Final Hemostasis: Confirmation of bleeding control prior to abdominal closure. | Procedure or surgery | Kasr Al-Ainy Technique Alone |
| Kasr Al-Ainy Technique + Hayman Sutures1. Vascular Ligation: Bilateral uterine artery tying at high and low levels. 2. Compression Sutures: Anterior and posterior cervicovaginal stitches for hemostasis. 3. Segmental Resection: Excision of invaded myometrium and placental tissue. 4. Dual-Layer Repair: Myometrial approximation followed by reinforcing imbricating sutures. 5. Final Hemostasis: Confirmation of bleeding control prior to abdominal closure. 6. Application of Hayman vertical compression sutures | Procedure or surgery | Kasr Al-Ainy Technique + Hayman Sutures |
Primary outcome
Intra-operative estimated blood loss
Time frame: During operation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Emad Salah, M.D. principal investigator
Cairo University
Mona Sedik, M.D. principal investigator
Cairo University
Questions about this trial
What is this clinical trial studying?
A study testing Kasr Al-Ainy Technique Alone and Kasr Al-Ainy Technique + Hayman Sutures in people with Placenta Accreta Spectrum, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abdallah Mousa, M.D. (+20 1277664430, Dr_abdallamousa@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intra-operative estimated blood loss (time frame: During operation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Apr 2026.