Clinical trials: Placebo Analgesia
Pain, Postoperative
Selective Block of the Axillary Nerve in Postoperative Pain Management
In this study the investigators wish to compare the effect of a selective axillary nerve block to placebo in patients undergoing arthroscopic shoulder surgery.
- Trial name
- NCT01463865
- Testing
- ropivacaine, Sodium chloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hillerod Hospital, Denmark
Dental Pain
A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
This is a Phase 2 study designed to test the ability of investigational study drug ARRY-371797 to reduce pain either perioperatively or postoperatively in a third molar extraction pain model, and to further evaluate the drug's…
- Trial name
- NCT00542035
- Testing
- ARRY-371797, p38 inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Pfizer
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Pain, Diabetic Neuropathy
Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy
The purpose of this study is to investigate if AZD2066 can relieve the pain arising from painful diabetic neuropathy compared to placebo.
- Trial name
- NCT00857623
- Testing
- AZD2066
- Where
- 19 sites in United States
- Volunteers
- 127 people
- Sponsor
- AstraZeneca
Osteo Arthritis of the Knee, Total Knee Anthroplasty
Dinalbuphine Sebacate in Postoperative Pain Control After TKA
To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty
- Trial name
- Naldebain (NCT07140510)
- Testing
- Dinalbuphine Sebacate, Normal Saline
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Colonoscopy, Pain
Procedural Pain Treatment With Transmucosal Sublingual Fentanyl Tablet in Colonoscopy Patients
Colonoscopy is generally considered an invasive procedure that causes remarkable pain to the patient. The pain associated with the procedure is not caused by the insertion of the scope but from inflating of the colon in order to…
- Trial name
- Abstral (NCT01604187)
- Testing
- Fentanyl
- Where
- Finland
- Volunteers
- 158 people
- Sponsor
- Turku University Hospital
Pain, Post-operative
Evaluation of N1539 Following Major Surgery
The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.
- Trial name
- NCT02720692
- Testing
- N1539
- Where
- 32 sites in United States, Australia and 2 more
- Volunteers
- 722 people
- Sponsor
- Baudax Bio
Hepatectomy
Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection
Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption.
- Trial name
- NCT03391427
- Testing
- Lidocaine, Ketamine, Lidocaine+ketamine
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pain
Randomized, Double-blind, Placebo, Controlled Cross Over Design Topical Morphine for Analgesia in Pediatric Procedures
Introduction: Opioids, such as morphine, act at receptors in the central nervous system, but many studies have suggested direct action peripherally on opioid receptors in sensory neurons terminals, melanocytes, keratinocytes and…
- Trial name
- NCT02300194
- Testing
- Topic Morphine
- Where
- Argentina
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Total Knee Arthroplasty, Analgesia
Local Infiltration Analgesia in Total Knee Arthroplasty
40 patients ASA I-III, undergoing total knee arthroplasty were randomly assigned, into one of two groups, namely group LIA (n=20), where local infiltration analgesia would be administered intraoperatively; and group sham LIA…
- Trial name
- NCT03206554
- Testing
- Ropivacaine, Saline
- Volunteers
- 40 people
- Sponsor
- Asklepieion Voulas General Hospital
Pelvic Pain, Endometriosis
Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery
This will be a prospective, randomized, double blinded placebo-controlled study at Erlanger hospital. Eligible patients who provide consent will be randomized into one of two arms receiving continuous intra-peritoneal local…
- Conditions
- Pelvic Pain, Endometriosis, Pelvic Prolapse
- Trial name
- NCT04118777
- Testing
- Ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee, Chattanooga
Postoperative Pain
Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery
This clinical trial is a multiple-center, randomized, double-blind, placebo- and active-controlled parallel-group Phase II/III clinical trial, to evaluate the efficacy and safety of HL-1186 Tablets for Postoperative Analgesia in…
- Trial name
- NCT07699601
- Testing
- HL-1186, Oxycodone-Acetaminophen
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Pain Management Following Cardiopulmonary Bypass Surgery
Use of Ketorolac in Management of Post-Operative Pain After Heart Surgery
This study evaluates the safety and efficacy of ketorolac for post-operative pain management after heart surgery. Ketorolac appears to provide enhanced pain relief while also decreasing the requirements for morphine during the…
- Trial name
- NCT00161577
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Pain After Surgery
A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Orthopedic Surgery
This is a multi-center, randomized, double-blind, placebo/active-controlled study. 200 subjects undergoing orthopedic surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine…
- Trial name
- NCT07551739
- Testing
- HSK55718 dose level 1, HSK55718 dose level 2, HSK55718 dose level 3
- Volunteers
- 200 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Anemia
Diclophenac Versus Placebo for Pain Control in Diagnostic Colonoscopy
Patients will be randomized to receive diclophenac sodium or placebo two hours before diagnostic colonoscopy. Intensity of pain as measured on a 10-point Likert scale will be the primary outcome.
- Trial name
- NCT02339428
- Testing
- diclophenac sodium
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- University Hospital Rijeka
Osteoarthritis, Gonarthrosis
Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis
Osteoarthritis (OA) is one of the main causes of chronic pain and physical disability, which directly impacts the quality of life of patients.
- Trial name
- NCT05975957
- Testing
- Photomodulation Therapy with the Light-Aid system, Control
- Where
- Brazil
- Volunteers
- 238 people
- Sponsor
- D'Or Institute for Research and Education
Chronic Low-back Pain
Cognitive Functional Therapy Compared With Sham-treatment for Low Back Pain
Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors.
- Trial name
- NCT04518891
- Testing
- Cognitive Functional Therapy (CFT)
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- University of Sao Paulo
Analgesia
Breath Metabolomics of Placebo Effects, a Pilot Study
This study is to analyze the breath metabolome before and after the administration of a placebo in an established experimental pain procedure in healthy subjects in order to investigate placebo effects, and whether they induce…
- Trial name
- BMPE (NCT04956718)
- Testing
- Cold Pressor Test (CPT)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Osteoarthitis, Chronic Pain
Efficacy and Safety of Tapentadol Extended Release Tablets in the Treatment of Moderate to Severe Pain in Subjects With Knee Osteoarthritis
The purpose of this study was to examine a low and high dose of tapentadol extended release tablet taken orally twice a day to reduce pain in subjects suffering from chronic moderate to severe pain due to osteoarthritis of the…
- Conditions
- Osteoarthitis, Chronic Pain, Knee Pain
- Trial name
- NCT00745069
- Testing
- tapentadol HCl
- Volunteers
- 670 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.