Clinical trials: Pigmentation Disorder
Chloasma
Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma
Melasma is a prevalent chronic facial pigmentation condition affecting Asian women of childbearing age, attributed to genetic predisposition, sunlight exposure, and hormonal changes.
- Trial name
- NCT06418568
- Testing
- Ultra-pulsed Shockwave Therapy Device by Shenzhen Lifotronic Technology Co., Ltd.
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyperpigmentation; Melanin
Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation
The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.
- Trial name
- NCT07133204
- Testing
- Investigator developed cream infused with HuangQin extract
- Where
- Thailand
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University
Melasma
Tri-split Face Study of Skin Resurfacing Modalities for the Treatment of Melasma
Tri-split face study of skin resurfacing modalities for the treatment of melasma, comparing the medium depth trichloroacetic acid peel, CO2 laser and Qs-NdYag laser.
- Trial name
- NCT02892071
- Testing
- 22% TCA peel, CO2 laser, Qs-NdYag laser
- Volunteers
- healthy volunteers welcome
- Sponsor
- SUZAN OBAGI
Glaucoma, Healthy
Cause of Pigment Dispersion Syndrome
The purpose of this study is to learn how pigment is released from the iris (the colored part of the eye) in patients with pigment dispersion syndrome.
- Conditions
- Glaucoma, Healthy, Pigment Dispersion Syndrome
- Trial name
- NCT00005919
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Keloid
Ethosomal Gel Bearing Losartan 5% for Keloid Treatment
The objectives are to compare the efficacy of pre and post-treatment and between 5% losartan potassium loaded in ethosomal gel and 10 mg/ml triamcinolone acetonide injection based on the indicator score of The patient and…
- Trial name
- NCT05893108
- Testing
- Ethosomal gel bearing losartan 5%, triamcinolone acetonide 10 mg/ml
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Yuni Eka Anggraini
Age-Related Macular Degeneration
The Role of Inflammation in AMD and Related Disorders
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
- Trial name
- NCT02588378
- Testing
- multi-modal cSLO imaging
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Melasma
Cysteamine Compared to Hydroquinone in Melasma
Melasma is an acquired pigmentary disorder of symmetrical hyperpigmentation appearing as variable darkness macules and patches over the forehead, cheeks, and chin, even sun-exposed areas of the body.
- Trial name
- NCT05969587
- Testing
- 5% cysteamine cream, hydroquinone cream group
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Melasma
A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma
This is a single centre, 2-cell, single blinded full-face (products applied at lesional sites) study to evaluate changes in melasma through a cosmetic facial serum formulation and marketed 2% Hydroquinone product
- Trial name
- NCT05013801
- Testing
- Cosmetic facial serum Q69, 2% Hydroquinone
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Melasma
Secretome TGF Beta 3
A therapeutic modality currently being developed for melasma is secretome. Secretome is a bioactive molecule secreted by mesenchymal stem cells in a conditioned medium containing a large number of growth factors, cytokines…
- Trial name
- TGF Beta 3 (NCT07137130)
- Testing
- Concentrated secretome Injection 3 mL, Concentrated secretome Injection 3 mL with addition of TGF Beta 3
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Vitiligo Vulgaris
Ginkgo Biloba for the Treatment of Vitiligo Vulgaris in Adolescents
Vitiligo is a common hypopigmentation disorder with significant psychological impact if occurring before adulthood. One study investigating the use of Ginkgo biloba for the treatment of vitiligo in adults reports effectiveness…
- Trial name
- NCT00907062
- Testing
- Ginkgo biloba
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Vitiligo
Human Beta-defensin 1 in Vitiligo
There is a need to know the role of human beta defensin-1 in vitiligo pathogenesis and the probability of finding newer and effective therapy for vitiligo in the future.
- Trial name
- NCT03832751
- Testing
- skin biopsy before and after NB-UVB phototherapy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hyperpigmentation
Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI
The primary objective of this study is to assess the efficacy of 1927nm non-ablative fractionated laser therapy to treat hyperpigmentation in patients ages 18-75 with Fitzpatrick Skin Phototypes V and VI and explore an effective…
- Trial name
- NCT05493280
- Testing
- MOXI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperpigmentation, Dark Spots
A Clinical Study to Assess the Effects of a Dark Spot Corrector on Dark Spots and Overall Complexion
This is a single-group, open-label, 90-day clinical study to assess the effectiveness of the Dark Spot Corrector by DIME Beauty on reducing the visibility of dark spots and improving overall complexion in females aged 50-65.
- Conditions
- Hyperpigmentation, Dark Spots, Skin Complexion
- Trial name
- NCT07900217
- Testing
- Dark Spot Corrector Group
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dime Beauty Co.
Postinflammatory Hyperpigmentation
Straberi Epistamp Device for Postinflammatory Hyperpigmentation
This pilot study will expand knowledge and application needling using the Straberi device for the improvement of Postinflammatory Hyperpigmentation (PIH) caused by acne.
- Trial name
- EPH (NCT04740255)
- Testing
- Straberi Epistamp
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universal Skincare Institute
Hyperpigmentation
Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos
This is a randomized, observer-blinded, vehicle-controlled multi-dose trial that examines the effect of twice daily application of 0.8% DBI-102 Gel, 4% Hydroquinone cream, and Vehicle Gel for 12 weeks in adults with Fitzpatrick…
- Trial name
- NCT05511948
- Testing
- DBI-102, Vehicle gel, Hydroquinone Cream
- Where
- El Salvador
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Hyperpigmentation
The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation
The goal of this clinical trial is to evaluate the efficacy of the novel lip product containing Caulerpa lentillifera extract on the appearance and perception of dark lips in Thai adults aged 18 to 60 who report concerns about…
- Trial name
- NCT07067879
- Testing
- Lip product
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Skin Ageing, Skin
Skin Type Determination Using Image Artificial Intelligence
Skin color, how easily a person burns or tans in the sun (skin phototype), and the amount of chronic sun damage in the skin are important factors in skin health.
- Trial name
- SPAI (NCT07765303)
- Testing
- Skin imaging and skin characteristic assessment
- Where
- 13 sites in Australia, Brazil and 9 more
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Region Skane
Skin Diseases
Adaption of the Skin Sun Sensitivity Scale
Determining Fitzpatrick skin phototypes (FST) allows physicians to assess a person's risk of developing sunburn, and thus the need for sun protection to prevent the development of skin cancer.
- Trial name
- NCT01975038
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.
BACKGROUND: Malar melasma has a chronic and recurrent character that may be related with epigenetic changes.
- Trial name
- NCT03392623
- Testing
- Retinoic acid, colorimetry measurement, sunscreen
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí