Clinical trials: Physiology
Healthy Volunteers, Exercise Physiology
Acute Effects of HIIT and MICT on Catestatin Dynamics in Young Males
Physical exercise acts as a major physiological stressor that alters cardiovascular and autonomic homeostasis. Catestatin (CTS), a bioactive peptide derived from chromogranin A (CgA), acts as a potent inhibitor of catecholamine…
- Conditions
- Healthy Volunteers, Exercise Physiology, Autonomic Nervous System Regulation
- Trial name
- NCT07819422
- Testing
- High-Intensity Interval Exercise, Moderate-Intensity Continuous Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Firat University
Healthy Young Adults, Physiology
Does Paracetamol Influence the Release of Gut Hormones, Glucose Absorption and Glycemia?
The study aim is to determine whether acute inhibition of endogenous prostaglandin synthesis by paracetamol affects the release of gut hormones, glucose absorption and glycemia in healthy young individuals
- Trial name
- NCT07821515
- Testing
- Paracetamol
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Normal Physiology
Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People
Background: Brain activity creates waste products. The body s glymphatic system removes this waste, especially during sleep. One brain waste product is amyloid-beta (Ab). It plays a role in Alzheimer s disease.
- Trial name
- NCT02669225
- Testing
- [18F]florbetaben
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology, Opioid Use Disorders
Brain Dopaminergic Signaling in Opioid Use Disorders
Background: The chemical messenger dopamine carries signals between brain cells. It may affect addiction. Heavy use of pain medicines called opioids may decrease the amount of dopamine available to the brain.
- Trial name
- NCT03190954
- Testing
- [11C]raclopride plus drug, [11C]NNC-112
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Exercise Physiology, Metabolic Hormones
Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in…
- Trial name
- ILEX (NCT07805772)
- Testing
- Aerobic Exercise, Anaerobic Exercise, High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inonu University
Telemedicine, Physiology
Assessment of Remote Vital Signs for Telemedicine Applications
The purpose of this study is to determine whether vital signs can be extracted from video. A secondary purpose is to create a database, including raw video, of "ground truth" physiological data on human subjects in order to test…
- Trial name
- NCT04820387
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Normal Physiology
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper the person s sleep.
- Trial name
- NCT02629107
- Where
- United States
- Volunteers
- 2,378 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Normal Physiology
Energy Expenditure Responses to Different Temperatures
Background: The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm.
- Trial name
- NCT01568671
- Testing
- Room temperatures
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Myocardial Injury, Atherosclerosis Cardiovascular Disease
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart.
- Conditions
- Myocardial Injury, Atherosclerosis Cardiovascular Disease, Cardiac Imaging Techniques, Genetics
- Trial name
- OXAMI (NCT07772570)
- Testing
- blood sampling, Intracoronary Imaging, Cardiovascular Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Exercise Physiology, High-Intensity Interval Training
Effects of a 10-Week High-Intensity Interval Training Programme on Biochemical and Hormonal Responses in Elite Female Futsal Players
This study aims to investigate the biochemical, hormonal, and physiological adaptations to a 10-week periodized high-intensity interval training (HIIT) programme in elite female futsal players.
- Conditions
- Exercise Physiology, High-Intensity Interval Training, Female Athletes, Menstrual Cycle
- Trial name
- NCT07773519
- Testing
- Repeated Futsal Performance Testing Across Menstrual Cycle Phases Intervention Description Participants will undergo standardized futsal-specific performance assessments during different phases of the
- Where
- Iraq
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Soran University
Type 1 Diabetes Mellitus, Exercise Physiology
Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise
This study evaluates a clinician-facing decision-support toolkit designed to assist adults with type 1 diabetes in preparing for moderate-intensity exercise.
- Trial name
- NEXT (NCT07226583)
- Testing
- Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Exercise, Fatigue
Physiological Responses to Basketball-Specific Interval Exercise in Female Basketball Players
This study aims to evaluate the effects of interval exercise on metabolic and inflammatory responses, energy substrate utilization, and fatigue in trained female basketball players.
- Conditions
- Exercise, Fatigue, Sport Physiology
- Trial name
- INTER-BASKET (NCT07752459)
- Testing
- Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo IR1)
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Exercise Physiology, Ventilatory Threshold
Modality-Specific Heart Rate Differences at Ventilatory Thresholds During Unified Ramp Testing
The purpose of this study was to investigate the heart rate bias between cycling and treadmill exercise at ventilatory thresholds. This was a randomized crossover trial involving 23 healthy participants.
- Conditions
- Exercise Physiology, Ventilatory Threshold, Heart Rate, Cycling and Treadmill Exercise
- Trial name
- NCT07718594
- Testing
- Cycle Ergometer CPET, Motorized Treadmill CPET (Porszász Protocol)
- Where
- Taiwan
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Human Gastrointestinal Physiology Data
Pharmacokinetic Study of Single-Dose Modified Release Glipizide in Healthy Volunteers
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study is to evaluate the in vivo drug dissolution and systemic absorption of modified release formulations of the BCS…
- Trial name
- NCT05159427
- Testing
- Glucotrol XL 5Mg Extended-Release Tablet, Glipizide ER 5 MG 24 HR Extended Release Oral Tablet, Rifaximin 200Mg Tab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fontan Physiology, Frailty
WE BEAT - HEART Club Fontan Wellness Project: A Virtual Resilience Promotion and Frailty Prevention Program
This trial is being conducted to evaluate the effect of a small-group wellness education program combined with a longitudinal, individualized prescription exercise program on the wellness, resiliency, and daily activity levels of…
- Conditions
- Fontan Physiology, Frailty, Single Ventricle Heart Disease
- Trial name
- NCT05199857
- Testing
- WE BEAT Group Wellness Education program - phase 1, HEART Club Home Exercise program - phase 2
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Fontan Physiology, Frailty
Home Exercise And Resiliency Training (Heart) Club
The purpose of this research study is to evaluate the impact of a telemedicine-based structured home exercise program on frailty and exercise capacity in individuals with Fontan heart physiology, demonstrate that a telemedicine…
- Trial name
- NCT05543733
- Testing
- Home exercise program
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Michigan
Healthy Adult Participants, Bone Physiology
Postprandial Regulation of Bone Perfusion in Healthy Individuals
The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.
- Conditions
- Healthy Adult Participants, Bone Physiology, Bone Blood Flow Regulation, Peptide Hormones
- Trial name
- GA-27 (NCT07679516)
- Testing
- isotonic saline infusion, Infusion of GIP(1-42), Infusion of GLP-2(1-33)
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen