Clinical trials: Physical Conditioning, Human
Exercise, Muscle
MyoGene: Effects of Acute Exercise on (Myokine) Gene Expression in Human Skeletal Muscle
Rationale: Proteins released from muscle during and shortly after exercise, often referred to as myokines, may be central to our understanding of the cross-talk during and after exercise between skeletal muscles and other organs…
- Conditions
- Exercise, Muscle, Gene Expression, Myokine
- Trial name
- NCT01316731
- Testing
- Single legged exercise
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Obesity, Inflammation
Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health
The goal of this project is to understand the combined effects of fish oil and exercise in obesity-associated inflammation. The investigators hypothesize that fish oil will improve gut bacteria profiles, which will in turn…
- Conditions
- Obesity, Inflammation, Human Microbiome, Insulin Resistance
- Trial name
- HIIT&PUFA (NCT05295719)
- Testing
- Omega-3 polyunsaturated fatty acid, High-Intensity Interval Training, Safflower oil
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Texas Tech University
Hepatitis C
Leptin and Liver Enzymes Responses to Aerobic Training in Hepatitis c Patients
Exercise is one of the most vital components of health maintenance. Exercising regularly maintains the cardiovascular system health, promotes the health of liver, and declines the risks of complications induced by CHCV.
- Trial name
- NCT04550273
- Testing
- aerobic treadmill exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Physical Inactivity
High-Intensity Interval Training and Monocyte Epigenetic Adaptation After Detraining
This randomized, work-matched training-detraining-rechallenge study evaluated whether repeated high-intensity interval training produces persistent functional and epigenetic adaptations in human monocytes.
- Trial name
- NCT07771075
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Training
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saif Rasheed Ghanim
Hepatitis C Virus Infection, Response to Therapy of
Effects of Activity and Education Program on Patients With Chronic Hepatitis C Infection
This 4-year project will be guided by a biobehavioral model for the study of exercise interventions in two phases with the purposes to : 1.
- Trial name
- NCT01572233
- Testing
- Personalized Physical Activity and Psycho-Education (PPAPE) Program
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acquired Immunodeficiency Syndrome, HIV Wasting Syndrome
Randomized Placebo-Controlled Study of Aerobic Exercise and Resistance Training Plus Megestrol Acetate for HIV-Wasting
OBJECTIVES: I. Evaluate the effect of aerobic exercise and progressive resistance plus megestrol acetate on lean body mass of patients with human immunodeficiency virus-related weight loss (HIV-wasting). II.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Wasting Syndrome, HIV Infections
- Trial name
- NCT00004664
- Testing
- megestrol, Exercise
- Volunteers
- 69 people
- Sponsor
- National Center for Research Resources (NCRR)
Gestational Diabetes
Usability Study of the Sensors and eMOM GDM Application
The principal aim of the eMOM GDM-project is to evaluate the effect of the eMOM GDM -application and the integrated service concept model on maternal and neonatal outcomes.
- Trial name
- eMOMGDM (NCT03941652)
- Where
- Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Vision Disorders
Bridging Animal and Human Models of Exercise-induced Visual Rehabilitation
This study will determine whether blood biomarker changes predict sight-saving benefits of exercise.
- Trial name
- NCT02911805
- Testing
- Aerobic exercise, Balance exercise
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes, Healthy Lifestyle Behaviors
Harnessing Human Potential and Improving Health Span in Women and Their Children
Women with Gestational Diabetes Mellitus (GDM) are 12-times more likely to develop Type 2 Diabetes (T2D) 4-6 years after delivery than women without GDM.
- Conditions
- Type 2 Diabetes, Healthy Lifestyle Behaviors, Gestational Diabetes
- Trial name
- HAPPY (NCT05949957)
- Testing
- LvL UP App, HAPPY App, Oura Ring And Oura App
- Where
- Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Emphysema
Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine if osteopathic manipulative treatment (OMT) is effective for persons with emphysema as a component of their chronic obstructive pulmonary disease.
- Trial name
- NCT00034112
- Testing
- osteopathic manipulative treatment
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Burn Injury
Cardiovascular Responses in Burn Survivors During Exercise
This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures, and associated indices of cardiovascular stress, during physical activity in…
- Trial name
- NCT06709781
- Testing
- Control (no cooling modalities), Water Spray
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Digital Technology, Healthy
A Vision-Based Characterization of Human Movement Scaling in Large-Amplitude Tasks
This pilot study investigates the feasibility of objectively quantifying movement amplitude and amplitude decay during large-amplitude exercises using RGB camera-based video analysis in healthy volunteers.
- Trial name
- NCT07387887
- Testing
- Large-Amplitude Exercise Observation and Video Recording
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Biruni University
Stem Cell Transplantation, Immunotherapy
Rehabilitation Needs for Hematologic Cancer Candidate for Hematopoietic Stem Cell Transplantation or CAR T-Cell Therapy
Hematopoietic Stem Cell Transplantation (HSCT) and CAR T-cell therapy are effective treatments for blood cancers, extending patients lives. However, these treatments can cause side effects like muscle weakness and fatigue.
- Conditions
- Stem Cell Transplantation, Immunotherapy, CAR T-Cell Therapy
- Trial name
- HEMATOneeds (NCT06506396)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Modena and Reggio Emilia
Sarcopenia
A Study of the Telerehabiliation Intervention Effect of the Tai Chi Exercise on Elderly With Sarcopenia
Sarcopenia is an age-related disease characterized by a progressive decrease in skeletal muscle content and loss of muscle function.
- Trial name
- NCT05767710
- Testing
- AI telerehabilitation - Tai Chi, general telerehabilitation - Tai Chi, traditional rehabilitation - Tai Chi
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Northeast Normal University
Obese, Obesity
The Effects of Chronic Exercise on UCP1 Gene in Human White Adipose Tissue
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk…
- Trial name
- NCT04039685
- Testing
- Effects of an eight weeks aerobic exercise followed by an eight weeks de-training period on UCP1 gene of human white adipose tissue, Effects of an eight weeks resistance exercise followed by an eight weeks de-training period on UCP1 gene of human white adipose tissue, Effects of an eight weeks combined (aerobic+resistance) exercise followed by an eight weeks de-training period on UCP1 gene of human white adipose tissue
- Where
- Greece
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Chronic Hepatitis B, Non-alcoholic Fatty Liver Disease
Chronic Hepatitis B Patients With Concurrent MAFLD: Cohort Study and Exercise Intervention.
In Taiwan, HBV infection is endemic in the adult population. With the westernization of eating habit and lifestyle, metabolic syndrome and related non-alcoholic fatty liver diseases (NAFLD, newly proposed as metabolic dysfunction…
- Trial name
- NCT05956379
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Physical Performance, Placebo Effect
Placebo Effect in Field-Based Physical Performance
This study aims to investigate the placebo (PLA) effect on physical performance across different sports disciplines in real-world, field-based settings.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07742150
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Schizophrenia, Schizotypal Disorder
Feasibility and Relevance of High-Intensity Functional Training in Patients With First-Episode Psychosis
The aim of the COPUS study is to investigate, whether it is possible to recruit and retain young people with first-episode psychosis, to an 8 week supervised High-Intensity Functional Training intervention (HIFT) (i.e.
- Conditions
- Schizophrenia, Schizotypal Disorder, First Episode Psychosis, Psychotic Disorders
- Trial name
- COPUS (NCT03409393)
- Testing
- The COPUS intervention, Usual Care (OPUS treatment)
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Skeletal Muscle, Human Performance
The Effects of L-arginine Supplementation on Anaerobic Exercise Performance
The purpose of this study is to evaluate if acute ingestion of L-arginine will enhance anaerobic exercise performance in young, healthy, and recreationally active adults.
- Trial name
- NCT06475391
- Testing
- L-arginine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba