Clinical trials: Pharmacology
Atrial Fibrillation, Paroxysmal
Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation.
The purpose of this randomized, double blind, placebo-controlled, superiority clinical trial was to assess clinical efficacy of potassium canrenoate - canrenone in rapid conversion of atrial fibrillation to sinus rhythm.
- Trial name
- CANREN-AF (NCT03536806)
- Testing
- Saline 0.9%, Canrenone
- Volunteers
- 80 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Obsessive Compulsive Disorder
Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients
The objective of this trial is to compare in an open trial format the efficacy of association of clomipramine and quetiapine with SSRI after SSRI treatment failed to produce complete remission of obsessive compulsive disorder…
- Trial name
- QCAT (NCT00564564)
- Testing
- Quetiapine, Clomipramine
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Multiple Sclerosis
Effect of Tai Chi on Balance, Mood, Cognition, and Quality of Life in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). The clinical picture is very variable, ultimately resulting in disability.
- Trial name
- TaiChi-SM (NCT05474209)
- Testing
- "Tai-chi" - a special program for patients with multiple sclerosis - once a week training with a Tai Chi instructor lasting 90 minutes
- Where
- Slovakia
- Volunteers
- 25 people
- Sponsor
- Comenius University
Treatment-resistant Schizophrenia
Sequential Treatment Approaches for Treatment-Resistant Schizophrenia
The goal of this study is to optimize treatment strategies for Chinese patients with treatment-resistant schizophrenia (TRS). It will compare two types of treatment: 1.
- Trial name
- STATRS (NCT07918222)
- Testing
- [Phase 1] Clozapine, [Phase 1] Aripiprazole, [Phase 1] Amisulpride
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Mental Health Center
Binge-Eating Disorder, Obesity
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment
Brief Summary: This study will compare the effectiveness of cognitive behavioral therapy (CBT), lisdexamfetamine (LDX), and the combination of CBT and LDX for the treatment of binge-eating disorder in patients with obesity.
- Trial name
- NCT03924193
- Testing
- Lisdexamfetamine Dimesylate, Cognitive-Behavioral Therapy, Combination LDX and Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Yale University
Thyroidectomy, Colon Surgery
Effect of the Coughing Technique During Subcutaneous Heparin Injection
Objective: to examine the effect of the medium intensity coughing technique during subcutaneous low molecular weight heparin injection on pain severity and individual satisfaction in general surgery patients.
- Conditions
- Thyroidectomy, Colon Surgery, Cholecystectomy, Inguinal Hernia
- Trial name
- NCT05681338
- Testing
- the medium intensity coughing technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uludag University
Overweight and Obesity
Evaluation of Non-pharmacological and Pharmacological Treatment for oVerweight and Obesity in pAtients of the Outpatient Register (EVA)
A prospective non-interventional single-centre study aimed to assess the current practice of non-pharmacological treatment and pharmacological therapy of overweight and obesity in patients with cardiovascular diseases (CVD) or…
- Trial name
- EVA (NCT03908216)
- Where
- Russia
- Volunteers
- 295 people
- Sponsor
- National Research Center for Preventive Medicine
Migraine
Efficacy of Individualized Homeopathic Remedies on Migraine: a Randomized, Triple-blind, Placebo Controlled Study.
Migraine, a chronic and often lifelong neurological disorder, is the second leading cause of years lived with disability worldwide.
- Trial name
- HOMEOMIG (NCT05468801)
- Testing
- Individualized Homeopathic Remedy
- Where
- Argentina
- Volunteers
- 72 people
- Sponsor
- Hospital General de Agudos Bernardino Rivadavia
Health Services for the Aged
Behavioral Pharmacology of Cannabis in Older Adults
This study examines the effects of cannabis on mood, cognitive and psychomotor performance, balance and vital signs in older adults.
- Trial name
- NCT06055309
- Testing
- Cannabis (up to three doses)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cervicobrachial Neuralgia
Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment
The purpose of this study is to compare the effectivity of Median Nerve Neural Mobilization and oral Ibuprofen in treating patients who suffer cervicobrachial pain
- Trial name
- NCT02593721
- Testing
- Median Nerve Neural Mobilization, Ibuprofen
- Where
- Venezuela
- Volunteers
- 50 people
- Sponsor
- Universidad Europea de Madrid
End Stage Renal Disease, Chronic Pain
HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis
HOPE is a randomized clinical trial that will evaluate approaches to reducing pain and opioid use among patients with chronic pain who are receiving maintenance hemodialysis for end-stage renal disease.
- Conditions
- End Stage Renal Disease, Chronic Pain, Opioid Dependence
- Trial name
- HOPE (NCT04571619)
- Testing
- Pain Coping Skills Training (PCST), Buprenorphine
- Where
- 16 sites in United States
- Volunteers
- 643 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Knee Osteoarthritis
Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
This phase I and II double blinded randomized clinical controlled trial investigates the safety and efficacy of intraarticular knee injection with allogenic adipose derived mesenchymal stem cells (AD-MSC), in patients suffering…
- Trial name
- STEMJOINT (NCT05933434)
- Testing
- Allogenic adipose derived mesenchymal stem cells (AD-MSC), Saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Dementia, Neurocognitive Disorders
Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's Disease
This multicentre study, with a randomised controlled repeated measures experimental design, will be conducted in several Portuguese institutions, which provide care and supportive services for older adults diagnosed with mild or…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT05433493
- Testing
- Cognitive stimulation
- Where
- 14 sites in Portugal
- Volunteers
- 142 people
- Sponsor
- Rsocialform - Geriatria, Lda
Myocardial Infarction
Effect of Renin Angiotensin Aldosterone System Genetic Polymorphism on the Pharmacological Effect of Mineralocorticoid Receptor Antagonists in Patients With Myocardial Infarction
Early treatment of Myocardial Infarction patients with mineralocorticoid receptor antagonist with help reduces the incidence of cardiac remodeling and development into heart failure.
- Trial name
- NCT05873400
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Hereditary Angioedema
A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase
The objectives of the study are to: 1. Evaluate the safety and tolerability of subcutaneously administered CINRYZE with recombinant human hyaluronidase (rHuPH20) in subjects with hereditary angioedema (HAE) who previously…
- Trial name
- NCT01426763
- Testing
- CINRYZE with rHuPH20
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Shire
Substance Use, Healthy Subjects
Abuse Potential and Human Pharmacology of Methylone
The purposes of the study are 1) To assess the abuse potential of methylone after controlled administration of a single oral dose of methylone 2) to evaluate subjective and physiological effects of methylone 3) to determine the…
- Trial name
- METI/FIS/1 (NCT05488171)
- Testing
- Methylone, 3,4-methylenedioxymethamphetamine
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Healthy Participants
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Adult Male Participants
The primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of multiple oral doses of E6130 in Japanese healthy adult male participants.
- Trial name
- NCT03390647
- Testing
- E6130
- Volunteers
- healthy volunteers welcome
- Sponsor
- EA Pharma Co., Ltd.
Acute Stress Ulcer and Acute Gastric Mucosal Lesions
Takepron Intravenous 30 mg Specified Drug-use Survey [Acute Stress Ulcer and Acute Gastric Mucosal Lesions]
The purpose of this survey is to evaluate the safety (that is, frequency of adverse events) and efficacy (that is, hemostatic effect, rate of rebleeding after confirmation of hemostasis) of administration of lansoprazole…
- Trial name
- NCT02170207
- Testing
- Lansoprazole
- Volunteers
- 63 people
- Sponsor
- Takeda
Pharmacological Action of Drug
the Incidence of Necrotizing Enterocolitis in Preterm With Respiratory Distress Syndrome Undergoing Caffeine Therapy
It is a randomized, prospective study; it will be carried out in the NICU at Alzahraa University Hospital including 50 newborn babies diagnosed with respiratory distress syndrome. The purpose of this study is to : 1.
- Trial name
- NCT06097767
- Testing
- Caffeine citrate, Amikacin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Pulmonary Disease, Chronic Obstructive
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.
- Trial name
- NCT00687700
- Testing
- GSK961081, Propranolol
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
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