Clinical trials: Phantom Limb Pain, active
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation
Venous Thromboembolism and Chronic Pain After Major Limb Trauma
Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability.
- Conditions
- VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- THROMBO-PAIN (NCT07475910)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Amputation
Feasibility of Neural Feedback for Lower Limb Amputees
The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with lower limb loss, including above and below knee amputees.
- Trial name
- NCT03409133
- Testing
- Stimulating nerve electrodes and intramuscular recording electrodes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Louis Stokes VA Medical Center
Stroke, Hemiparesis
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated…
- Conditions
- Stroke, Hemiparesis, Phantom Limb Pain
- Trial name
- StimNeuro (NCT05766059)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Istituto Auxologico Italiano
Phantom Limb Pain After Amputation
Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCS
Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of chronification.
- Trial name
- NCT07139483
- Testing
- Trans Direct-Cranial Stimulation (tDCS), Mirror therapy
- Where
- 3 sites in Israel
- Volunteers
- 108 people
- Sponsor
- University of Haifa
Residual Limb Pain, Amputation Neuroma
Surgical Treatments for Postamputation Pain
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP).
- Conditions
- Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic
- Trial name
- NCT05009394
- Testing
- Targeted Muscle Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), Standard neuroma treatment, neuroma excision, and muscle burying
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 110 people
- Sponsor
- Prometei Pain Rehabilitation Center
Amputation, Surgical, Pain Management
Early Postoperative Pain Following a Limb Amputation
The primary aim of this study is to characterize the trajectory of pain and functional recovery in the first post-operative period following a limb amputation.
- Conditions
- Amputation, Surgical, Pain Management, Rehabilitation
- Trial name
- Pain-Amp (NCT07393139)
- Testing
- Pain assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Ortopedico Rizzoli
Phantom Limb Pain, Amputation
TITAN Trial: Reducing Phantom Limb Pain in People with Amputations
The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain.
- Trial name
- TITAN (NCT06167330)
- Testing
- Progressive rehabilitation program, Stimulation devices
- Where
- Australia
- Volunteers
- 208 people
- Sponsor
- Neuroscience Research Australia
Phantom Limb Pain
Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations
Nearly 60-85% of Veterans with amputations experience pain at the location of the amputated limb called phantom limb pain (PLP).
- Trial name
- NCT06106984
- Testing
- Graded motor imagery mobile app
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Phantom Limb Pain
Psilocybin-assisted Therapy for Phantom Limb Pain
This double-blind placebo-controlled pilot study seeks to investigate whether psilocybin can be safely administered to people with chronic phantom limb pain (PLP) in a supportive setting with close follow-up, and its effects on…
- Trial name
- NCT05224336
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Diego
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Phantom Pain
Neural Bases of Phantom Pain After Amputation
The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time.
- Trial name
- Phantom limb (NCT05545358)
- Testing
- Questionnaires, Brain and Spinal Cord functional Magnetic Resonance Imaging, Proprioceptive training
- Volunteers
- 75 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Phantom Limb Pain, Amputation, Traumatic
Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS)
This is a two-site study that explores the effects of mirror therapy and transcranial Direct Current Stimulation (tDCS, Soterix ©) in a randomized factorial controlled trial in which patients will be assigned to one of four…
- Trial name
- NCT02487966
- Testing
- transcranial Direct Current Stimulation (tDCS): active (Soterix ©), Mirror Therapy: active
- Where
- 2 sites in United States, Brazil
- Volunteers
- 132 people
- Sponsor
- Spaulding Rehabilitation Hospital
Lower Limb Amputation
Uses of Phantom Sensations Induced by Global and Local Modifications of the Prosthetic Socket as Somatosensory Feedback During Walking in Lower Limb Amputees
Following lower-limb amputation, the loss of somatosensory information from the missing limb renders walking less automatic, more cognitively demanding, and often asymmetric, which can lead to secondary pathologies.
- Trial name
- PhantomWalk (NCT07191795)
- Testing
- Gait analysis, Mapping of referred sensations., Exploration of the areas of the brain activated during referred sensations
- Where
- France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Amputation
Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation
This clinical trial evaluates two surgical techniques (targeted muscle re-innervation [TMR] and regenerative peripheral nerve interfaces [RPNI]) alone and in combination for the alleviation of chronic residual limb and phantom…
- Trial name
- NCT06840262
- Testing
- Questionnaire Administration, Regenerative Peripheral Nerve Interface Surgery, Targeted Muscle Reinnervation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- M.D. Anderson Cancer Center
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Phantom Limb Pain
Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life
This clinical trial is designed to assess the effectiveness of advanced neuromodulation techniques in reducing phantom limb pain by improving sensory feedback in bionic prostheses.
- Trial name
- NCT06702904
- Testing
- Peripheral Nerve Stimulation, Spinal cord stimulation, Dorsal Root Ganglion Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology