Clinical trials: Phantom Limb
Phantom Limb Pain
Examining Brain Changes Using Functional Magnetic Resonance Imaging (fMRI) in Amputees With Phantom Limb Pain Following Mirror Therapy
Almost everyone who has a traumatic limb amputated will experience a phantom limb - the vivid impression that the limb not only still is present, but also in many cases, painful.
- Trial name
- NCT00662415
- Testing
- mirror-box treatment, observation
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Phantom Pain Following Amputation of Lower Limb
the Influence of Virtual Reality Approach on Phantom Pain in Trans Tibial Amputation
1. To investigate the effect of Virtual reality (VR) on phantom limb pain in trans tibial amputation. 2. To investigate the effect of Virtual reality (VR) on lower limb Function in trans tibial amputation.
- Trial name
- NCT06262503
- Testing
- Virtual Reality, Transcutaneous Electrical Nerve Stimulation (TENS), Mirroring Therapy
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Post-Amputation Pain, Phantom Limb Pain
Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) can safely and effectively reduce post-amputation pain. This study involves a device called the SPRINT System.
- Conditions
- Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
- Trial name
- NCT01996254
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- SPR Therapeutics, Inc.
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Ischemia, Phantom Limb Pain
Sciatic Perineural Versus Stump Catheter for Below Knee Amputation
The goal of this study is to determine if pre-operative placement of the continuous peripheral nerve block by an anesthesiologist using ultrasound technology is more effective than a continuous peripheral nerve block placed…
- Conditions
- Ischemia, Phantom Limb Pain, Vascular Disease, Chronic Pain
- Trial name
- NCT01608035
- Testing
- Sciatic catheter, Stump catheter
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University of British Columbia
Neuropathic Pain, Phantom Limb Pain
Clinical Evaluation of the Medical Device (MD) (Caloprothese Connected Kit, CCK)
Neuropathic pain is common in limb amputees and causes reductions in activity and participation as well as impaired quality of life.
- Trial name
- KCC (NCT04748484)
- Testing
- KCC Active or inactive
- Where
- 4 sites in France
- Volunteers
- 12 people
- Sponsor
- Gregand Innovations
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Phantom Limb Pain, Amputation
Effect of Femoral and Sciatic Nerve Blocks, Combined with General Anesthesia, in Postoperative Pain Levels and Phantom Limb Pain Development in Patients Undergoing Lower Limb Amputation
The goal of this observational study is to determine the effect of femoral and sciatic nerve blocks, combined with general anesthesia, in postoperative pain levels and phantom limb pain development in patients undergoing lower…
- Conditions
- Phantom Limb Pain, Amputation, Anesthesia, Local
- Trial name
- NCT06693427
- Testing
- Peripheral Nerve Block
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- DIMITRIOS KATSAROS
Phantom Limb Pain
Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment Response
The investigators have designed a pragmatic trial of home-based transcranial direct current stimulation (tDCS) for phantom limb pain (PLP), the PLP-EVEREST trial (PLP-EffectiVEness pRagmatic Stimulation Trial) to test a portable…
- Trial name
- PLP-EVEREST (NCT05188183)
- Testing
- M1 anodal home-based tDCS, Somatosensory Training, Usual Care
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Spaulding Rehabilitation Hospital
Amputation, Surgical, Amputation, Traumatic
Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Conditions
- Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
- Trial name
- NCT06071715
- Testing
- ACTIVE cryoneurolysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Pain in Trans Femoral and Trans Tibial Amputees
Phantom limb is difficult to manage and has a significant impact on the patient's quality of life. At present, the scientific evidence shows that the infusion of local anesthetics with epidural and perineural catheters in the…
- Trial name
- AMPUPHANTOM (NCT03789435)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Ortopedico Rizzoli
Phantom Pain Following Amputation of Lower Limb, Amputation
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- PLP Home-Based (NCT07044323)
- Testing
- Active Virtual Reality Treatment
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Albert Einstein Healthcare Network
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 2)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750538
- Testing
- BreEStim 120, BreEStim 240
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- The University of Texas Health Science Center, Houston
Amputation, Phantom Pain Following Amputation of Lower Limb
Effectiveness of Mirror Therapy in Patients With Amputations of Lower Limbs of Vascular Origin
The aim of this study is to assess the efficacy of the mirror therapy on phantom pain for patients with amputation after vascular etiology.
- Trial name
- MIR-PHAN (NCT03149432)
- Testing
- Mirror Therapy, Gabapentin, Rehabilitation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Pain, Neuropathic, Complex Regional Pain Syndromes
Modulating Neuropathic Pain With Transcranial Direct Current Stimulation
This study will examine whether a form of non-invasive brain stimulation can help reduce pain in people with persistent neuropathic pain.
- Conditions
- Pain, Neuropathic, Complex Regional Pain Syndromes, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT04581525
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Susan McDowell
Phantom Limb Pain
Use of Hand Prosthesis With Direct Nerve Stimulation for Treatment of Phantom Limb Pain
Phantom limb pain (PLP) is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours…
- Trial name
- EPIONE (NCT02506608)
- Testing
- Operation of sensorized hand prosthesis
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Paolo Maria Rossini
Post-Amputation Pain, Phantom Limb Pain
Electrical Nerve Block for Amputation Pain
The purpose of the clinical trial is to learn whether electrical nerve block via the Altius System is a safe and effective treatment for patients with post-amputation pain.
- Conditions
- Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain, Stump Pain
- Trial name
- NCT02221934
- Testing
- Altius
- Where
- 22 sites in United States
- Volunteers
- 607 people
- Sponsor
- Neuros Medical, Inc.
Amputation
Feasibility of Neural Feedback for Lower Limb Amputees
The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with lower limb loss, including above and below knee amputees.
- Trial name
- NCT03409133
- Testing
- Stimulating nerve electrodes and intramuscular recording electrodes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Louis Stokes VA Medical Center
Neuropathic Pain, Phantom Pain
Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Phantom pain is associated with cortical reorganization after amputation. This phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered.
- Conditions
- Neuropathic Pain, Phantom Pain, Sex Reassignment Surgery
- Trial name
- NPASRS (NCT04538170)
- Testing
- pain after surgery
- Where
- Germany
- Volunteers
- 423 people
- Sponsor
- University Hospital Tuebingen
Phantom Limb Pain
Sensory Retraining for Phantom Limb Pain
86-87% of people who have had an amputation still feel pain in the limb that has been amputated - Phantom limb pain (PLP). Sensory retraining is a form of treatment for PLP where a special form of electrical stimulation is…
- Trial name
- PHANTOM RELIEF (NCT04103983)
- Testing
- Sensory retraining device
- Where
- United Kingdom
- Volunteers
- 109 people
- Sponsor
- Teesside University