Clinical trials: Peyronie Disease
Peyronies Disease
Platelet-Rich Plasma for Peyronie's Disease
The purpose of this clinical trial is to evaluate the effects of Platelet-Rich Plasma (PRP) intralesional injections in men affected by Peyronie's disease (PD) in the fibrotic phase.
- Trial name
- NCT07117955
- Testing
- Autologous Platelet Rich Plasma, Saline solution
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Herlev Hospital
Peyronies Disease
Treatment of Peyronie's Disease With Platelet-Rich Plasma
The purpose of this pilot study is to optimize a planned randomized, double-blind, placebo-controlled clinical trial evaluating the effects of Platelet-Rich Plasma (PRP) intralesional injections in men affected by Peyronie's…
- Trial name
- NCT06789510
- Testing
- Autologous Platelet Rich Plasma, Saline solution
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Herlev Hospital
Peyronie Disease
Safety and Efficacy of Intralesional HiLow Hyaluronic Acid in the Treatment of Peyronie's Disease (PD)
Prospective, open-label, single-arm, multicentric, pilot clinical study to confirm the safety of HiLow hyaluronic acid sodium salt for intralesional penile injection in patients affected by PD.
- Trial name
- NCT05871177
- Testing
- Pre-filled syringe of HiLow Hyaluronic Acid Sodium Salt
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Peyronie Disease
Non-ablative Radiofrequency and Low Intensity Shock Wave Therapy in Fibrotic Plaque in Men With Peyronie's Disease
The goal of this one arm clinical trial is to evaluate the safety and describe the clinical response of non-ablative radiofrequency treatment associated with shockwave therapy in men with Peyronie's disease.
- Trial name
- NCT06303661
- Testing
- Non-ablative Radiofrequency, Low-intensity Shock Wave Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Peyronie's Disease
Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease
Two recent studies have identified low levels of serum testosterone in association with Peyronie's Disease (PD), with a significant correlation noted between severity of testosterone deficiency and severity of curvature.
- Trial name
- PD+ (NCT01578473)
- Testing
- Vitamin D2, Vitamin E, Testosterone Pellets
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Men's Health Boston
Peyronies Disease
Fractionated Carbon Dioxide Laser Therapy for Treatment of Peyronie's Disease
This is a pilot study that evaluates the use of Fractional Carbon Dioxide Laser Therapy in the treatment of Peyronie's Disease. Study participants will be assigned to receive Fractional Carbon Dioxide Laser Therapy at 10-15%…
- Trial name
- NCT04326465
- Testing
- Fractional Carbon Dioxide Laser Therapy at 10-15% Laser Density Coverage
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Peyronie's Disease
Real-World Data Study to Understand Effectiveness of Treatments in Peyronie's Disease
This is an observational study, meaning participants will not receive any investigational treatment as part of this study. Researchers will collect real-world data (RWD) to gain a more in-depth knowledge of the treatment of…
- Trial name
- CURVE-PD (NCT05873595)
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Peyronie's Disease
Efficacy of a Novel CCH Protocol for PD Among Prior Non-responders
Compare key clinical outcomes between controls and men treated with a novel CCH administration protocol among men previously unresponsive to CCH administration.
- Trial name
- NCT05108558
- Testing
- CCH administration, Control - Crossover to CCH, RestoreX
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Charitable Union for the Research and Education of Peyronie's Disease
Peyronie's Disease (PD)
Comparative Outcomes of Subtunical Microdissection and Grafting Versus Classical Plaque Incision and Grafting in Complex Peyronie's Disease
The goal of this clinical study is to compare two surgical techniques used for the treatment of complex Peyronie's disease. Peyronie's disease can cause penile curvature, deformity, and difficulties during sexual intercourse due…
- Trial name
- Peyronie (NCT07470528)
- Testing
- Subtunical microdissection and grafting, Classic plaque Incision and Grafting
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Peyronie's Disease, Hyaluronic Acid
Intralesional Hyaluronic Acid and Verapamil Injection in Peyronie's Disease
The aim of the present study is to investigate whether intralesional injections of Hyaluronic acid in the acute phase could reduce the progression of Peyronie's disease thanks to its interference with inflammatory and…
- Conditions
- Peyronie's Disease, Hyaluronic Acid, Verapamil
- Trial name
- NCT05855070
- Testing
- Intralesional treatment with Hyaluronic acid, Intralesional treatment with Verapamil
- Volunteers
- 42 people
- Sponsor
- Benha University
Peyronie's Disease
A Phase 3, Open-label Study of the Safety and Effectiveness of AA4500 Administered Twice Per Treatment Cycle for up to Four Treatment Cycles (2 x 4) in Men With Peyronie's Disease
This study is a Phase 3, open-label study of the safety and efficacy of AA4500 0.58 mg in subjects with Peyronie's disease. Subjects will be screened for study eligibility within 21 days before the initial injection of study drug…
- Trial name
- NCT01685437
- Testing
- AA4500
- Volunteers
- 189 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Peyronie Disease, Sexual Dysfunctions, Psychological
Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional PRP for Peyronie's Disease
The purpose of this study is to learn about the safety and side effects of intralesional collagenase clostridium histolyticum (CCH) injected into the Peyronies Disease (PD) plaque after receiving prior treatment with…
- Conditions
- Peyronie Disease, Sexual Dysfunctions, Psychological, Genital Diseases, Male
- Trial name
- NCT05777031
- Testing
- Collagenase Clostridium Histolyticum (CCH)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Miami
Peyronie Disease, Erectile Dysfunction
Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease
The purpose of this research is to determine whether or not low-intensity shockwave therapy (LiSWT) with Xiaflex treatment will result in greater improvements to the curvature of the penis.
- Trial name
- NCT06065436
- Testing
- Collagenase Clostridium Histolyticum, Storz Duolith LiSWT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Peyronie Disease
Extracorporeal Shockwave Therapy in the Treatment of Peyronie's Disease
Investigation of the effectiveness of extracorporeal shock wave therapy in the treatment of Peyronie's disease.
- Trial name
- NCT07317297
- Testing
- Extracorporeal Shockwave Therapy, control
- Where
- Azerbaijan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Peyronie Disease
Does Size Matter: A Single Case Experimental Design of Limiting the Depth of Penetration During Intercourse
Our hypothesis is that reducing the length of the penis does not lead to loss of sexual satisfaction or emotional closeness in the female partner. This will be investigated by a single case experimental design in 12 couples.
- Trial name
- NCT04052217
- Testing
- Penile Ring
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King's College London
Peyronie's Disease
Additional Xiaflex® Treatment in Patients With Peyronie's Disease Recurrence, Worsening, or Incomplete Response
Subjects who have had an incomplete response to previous Xiaflex® will receive up to 4 additional cycles of treatment.
- Trial name
- NCT03767452
- Testing
- Xiaflex® 0.58 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Manhattan Medical Research Practice, PLLC
Peyronie's Disease
An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie's Disease
Enrollment will include approximately 30 AA4500 naïve subjects. Subjects will be divided by degree of penile curvature and then randomized in a 1:1 ratio to one of the following treatment groups: AA4500 with investigator modeling…
- Trial name
- NCT02267460
- Testing
- AA4500, ErecAid® Esteem® Manual Vacuum Therapy System, Investigator Modeling
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Peyronie Disease
Novel Nanofat Regenerative Surgical Technique for Peyronies' Disease Treatment
Peyronies' disease (PD) is an acquired connective tissue disorder characterized with the growth of fibrous and/or calcified plaques in the tunica albuginea of the penis.
- Trial name
- IPPNANOFAT (NCT05316714)
- Testing
- Nanofat grafing
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Roma La Sapienza
Peyronies Disease
Title Fractioned CO2 Laser in the Treatment of Chronic Phase Peyronie's Disease
Peyronie's Disease (PD) is a fibrosing disorder of the penis where scar tissue (composed of excessive and disorganized collagen) known as a "plaque," forms along the shaft of the penis.
- Trial name
- NCT07177833
- Testing
- Fractional CO2 laser
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Peyronie Disease, Penile Curvature
Focused Shock Wave Therapy Outcomes in Peyronie's Disease and Erectile Dysfunction
The purpose of this research is to determine the pure or additional effects of penile shockwave therapy with low intensity linear shock wave machine for penile curvature (and/or erectile dysfunction) vs patients' undergoing other…
- Conditions
- Peyronie Disease, Penile Curvature, Erectile Dysfunction
- Trial name
- NCT05646602
- Testing
- Collagenase Clostridium Histolyticum, Duolith SD1 T-TOP
- Where
- United States
- Sponsor
- Mayo Clinic