Clinical trials: Perturbation
Diabetic Foot Ulcer
A RCT to Compare the Effects of Two Wound Products on Biofilm Disruption in DFUs
This study is a prospective comparative study to determine if an Iodine Gel (Iodosorb◊) is better than standard dressing (Solosite◊ gel) in disruption of biofilm (small microorganism bacteria similar to plaque on teeth) on the…
- Trial name
- NCT02181621
- Testing
- Iodosorb, Solosite gel
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Smith & Nephew, Inc.
HIV Infection
Safety and Efficacy Study of AGS-004 During Analytical Treatment Interruption
The purpose of this study is to determine the safety and effectiveness of AGS-004, an immune therapy, for HIV-infected individuals.
- Trial name
- NCT01069809
- Testing
- AGS-004
- Where
- 9 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Argos Therapeutics
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate the safety, tolerability, and feasibility of Blood-Brain Barrier (BBB) opening using transcranial MRI-guided focused ultrasound in conjunction with an intravenous ultrasound contrast agent…
- Trial name
- NCT03321487
- Testing
- Blood-Brain Barrier opening with MRgFUS
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- InSightec
HIV
A Clinical Trial of Analytical Treatment Interruption in People With HIV With a Highly Favourable Profile
A pilot single exploratory clinical trial of ATI in a selected sample of PWH sharing specific genetic, phenotypic and clinical characteristics.
- Trial name
- CLINIC-CURE (NCT07875504)
- Testing
- Treatment interruption
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Non-alcoholic Steato-hepatitis
: Identification of Non-alcoholic Steato-hepatitis Cases in a Sample of Type 2 Diabetes Patients, with a Disruption of the Liver Function Tests, At the Pointe-à-Pitre University Hospital
Non-alcoholic steatohepatitis (NASH) develops on insulin resistance, especially in patients with carbohydrate tolerance. NASH may progress to more extensive fibrosis, including cirrhosis, but also to HCC with or without cirrhosis…
- Trial name
- STEATOGWAD (NCT06738810)
- Testing
- Fibrotest-actitest/NASHtest
- Where
- Guadeloupe
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Disruption or Dehiscence of Closure of Sternum or Sternotomy
Treatment With PTH After Sternotomy in Cardiac Surgery Patients
The aims of this study is to compare healing time and quality of newly formed bone in cardiac surgery patients treated with PTH post-surgically and a control group treated with saline.
- Trial name
- PAATH (NCT01466829)
- Testing
- Parathyroid hormone
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Apnea of Prematurity
Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study
Apnea of prematurity is a common condition that is usually treated with methylxanthines. Methylxanthines are adenosine receptor blockers that have powerful influences on the central nervous system.
- Trial name
- CAP-S (NCT01020357)
- Testing
- Caffeine citrate injection
- Where
- 4 sites in Australia, Canada
- Volunteers
- 201 people
- Sponsor
- McMaster University
Sleep, Circadian Rhythm
Impact of Sleep Disruption on the Menstrual Cycle
The purpose of this study is to investigate whether sleep disruption affects menstrual cycle timing
- Conditions
- Sleep, Circadian Rhythm, Menstrual Cycle
- Trial name
- NCT00456222
- Testing
- Disrupting or changing the timing or the duration of sleep
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation (AF), VTE
Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure
PAUSE 2 study is a prospective, open-label, blinded-endpoint non-inferiority RCT of PAUSE vs. ASRA management in DOAC treated high risk patients with AF/VTE who need elective high bleed risk surgery/procedure and/or any procedure…
- Trial name
- PAUSE 2 RCT (NCT06957366)
- Testing
- PAUSE Perioperative DOAC Management, ASRA Perioperative DOAC Management
- Where
- 14 sites in United States, Belgium and 2 more
- Volunteers
- 920 people
- Sponsor
- McMaster University
Spinal Tumors
Liquid Biopsy Following BBB Disruption Using Barrier Disrupting Fields in Patients Undergoing Spine Surgery
Objective: To identify new central nervous system (CNS) biomarkers to be used for blood-derived liquid biopsy once the blood-brain barrier (BBB), specifically the blood-arachnoid barrier (BAB), has been transiently disrupted by…
- Trial name
- BDF002 (NCT07224451)
- Testing
- spinal surgery, BDF
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Disruption of Uterine Incision After Cesarean Section
Randomized Comparison of Sharp Versus Blunt Techniques at Cesarean
The purpose of this study is to determine whether a specific surgical technique, blunt compared with sharp expansion of the transverse lower uterine incision, is associated with risk of unintended extension of uterine incision
- Trial name
- NCT01519440
- Where
- Turkey (Türkiye)
- Volunteers
- 1,076 people, healthy volunteers welcome
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with…
- Conditions
- Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form, Septo-Optic Dysplasia, Optic Nerve Hypoplasia
- Trial name
- NCT06760546
- Testing
- Setmelanotide
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Leiomyosarcoma, Liposarcoma
Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin
Two arm, randomized, open-label study, to determine the best time to secondary resistance between responding patients who discontinue treatment and resumed Trabectedin at the time of progression versus patients who continued…
- Conditions
- Leiomyosarcoma, Liposarcoma, Synovial Sarcoma
- Trial name
- TRADITIONS (NCT03773510)
- Testing
- Trabectedin discontinuation, Trabectedin continuation
- Where
- 15 sites in Italy
- Sponsor
- Italian Sarcoma Group
Sleep Initiation and Maintenance Disorders, Breast Cancer
Acupuncture for Sleep Disruption in Cancer Survivors
The proposed study will recruit 60 women with breast cancer who finished undergoing treatment who complain of persistent insomnia problems that began with onset of their cancer diagnosis.
- Trial name
- NCT01162018
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
HIV Infection
Immune Therapy and Analytical Treatment Interruption in HIV+ Participants Who Received an Allogeneic Stem Cell Transplantation
The availability of antiretroviral therapy (cART) for HIV-1 infection has led to a reduction in morbidity in patients with chronic HIV infection.
- Trial name
- ITATI (NCT04720742)
- Testing
- Analytical Treatment Interruption + bNAbs infusion
- Where
- 4 sites in Italy, Netherlands and 1 more
- Sponsor
- IrsiCaixa
Healthy
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis
The purpose of this study is to explore the impact of aged blood on endothelial function by measuring forearm blood flow during intra-arterial acetylcholine infusion in normal healthy human volunteers after infusion of autologous…
- Trial name
- NCT01137656
- Testing
- Acetylcholine and Blood
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mark Gladwin
Circadian Rhythm Disruption, Delirium
DElirium and LIGHT: Exploring Modifiable Risk Factors of Delirium - a Pilot Study
After a period of critical illness many people develop problems with memory, attention and thinking and this can make daily life more difficult. A risk factor for these problems is delirium.
- Trial name
- DELIGHT-P (NCT07791472)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College Hospital NHS Trust
Endothelial Dysfunction
Endothelial Function After Cardiac Surgery
The purpose of this study is to evaluate whether patients receiving human albumin for plasma volume replacement during cardiac surgery have improved postoperative endothelial function compared to patients receiving 6%…
- Trial name
- NCT02882074
- Testing
- Human albumin, Hydroxyethyl starch
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- The Cleveland Clinic
Delirium, Postoperative
Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly
Postoperative delirium (POD) is the most common complications (~50-60%) in elderly and major challenges to our rapidly growing aging population.
- Trial name
- NCT06090955
- Testing
- Dexmedetomidine Injection [Precedex], Lidocaine IV, normal saline
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Samsung Medical Center
Glioma, Glioblastoma
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption
The purpose of this study is to evaluate the safety of the ExAblate Model 4000 Type 2 used as a tool to disrupt the BBB (blood brain barrier) in patients with high grade glioma undergoing standard of care therapy.
- Trial name
- NCT03551249
- Testing
- Focused ultrasound (FUS)
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- InSightec