Clinical trials: Persistent Post Operative Opioid Use
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Persistent Postsurgical Pain, Arthritis Knee
Persistent Pain After Knee Replacement
This study is a nationwide cross-sectional survey on pain and satisfaction after knee arthroplasty (KA). Please find the full protocol uploaded at ClinicalTrials.gov The goal of this observational study is to study pain and…
- Conditions
- Persistent Postsurgical Pain, Arthritis Knee, Neuropathic Pain, Opioid Use
- Trial name
- NCT05900791
- Testing
- Primary knee arthroplasty
- Where
- Denmark
- Volunteers
- 3,710 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Persistent Postsurgical Pain, Arthritis Hip
Persistent Pain After Hip Replacement
This study is a nationwide cross-sectional survey on pain and satisfaction after total hip arthroplasty (THA). Please find the full protocol uploaded on ClinicalTrials.gov
- Conditions
- Persistent Postsurgical Pain, Arthritis Hip, Neuropathic Pain, Opioid Use
- Trial name
- NCT05845177
- Testing
- Primary Total Hip Arthroplasty
- Where
- Denmark
- Volunteers
- 2,777 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Opioid Use Disorder, Opioid Consumption
Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery
The mechanisms leading to opioid tolerance or dependence are not well understood and there are currently no biomarkers for predicting who is at risk for development of OUD.
- Conditions
- Opioid Use Disorder, Opioid Consumption, Persistent Opioid Use, Persistent Postsurgical Pain
- Trial name
- NCT07693270
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Opioid Use
A Difference-In-Differences Analysis of New Persistent Opioid Use After Surgery
The Michigan Opioid Prescribing and Engagement Network (M-OPEN) was established in 2016 with the goal of reducing excessive opioid prescribing after surgery using evidence-based prescribing guidelines.
- Trial name
- NCT04805229
- Testing
- Retrospective analysis of opioid use after surgery
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Opioid Consumption, Postoperative
Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)
The purpose of the study is to investigate the efficacy of suzetrigine for treatment of acute postoperative pain among surgical patients identified as high risk for persistent postoperative opioid use (POU).
- Trial name
- NCT07672015
- Testing
- Suzetrigine, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Aucte Pain After Surgery, Persistent Pain After Surgery
The Recuperation of Patients After Elective Shoulder Surgery Observational Cohort Study
Around 6400 shoulder surgeries are performed yearly in Finland. The procedure is mainly day-case surgery and the patients go home in the afternoon.
- Conditions
- Aucte Pain After Surgery, Persistent Pain After Surgery, Opioid Use After Surgery, Mode of Anaesthesia
- Trial name
- NCT03335410
- Testing
- Non- interventional
- Where
- 14 sites in Finland
- Volunteers
- 122 people
- Sponsor
- Tampere University Hospital
Analgesic Drug Dependence, Colectomy
Opioid Free Anesthesia vs. Opioid Anesthesia Techniques.
A comparison of post-operative opioid use in Laparoscopic Colectomy patients receiving Opioid or Opioid-free Anesthesia.
- Trial name
- OFA vs OA (NCT03367988)
- Testing
- Opioid Anesthesia, Opioid-free Anesthesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Post Operative Pain, Opioid Use, Unspecified
Sensory Outcomes in Active Substance Users
The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes.
- Trial name
- NCT06639438
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Perioperatoire Medicine, Surgery
Evaluation of a Structured Hospital-Community Care Follow-up Based on Perceived Quality of Care After Surgery, Aimed at Reducing Persistent Opioid Use in Primary Care: a Pragmatic Randomized Controlled Trial
The OPTIMISTE program is based on a structured postoperative follow-up centered on patients' subjective perception of recovery using validated Patient Reported Outcome Measures (PROMs), including the mQoR-15f score.
- Trial name
- OPIOID CITY FR (NCT07659730)
- Testing
- Patient-Reported Outcomes-based perioperative follow-up (QoR-15 focus)
- Volunteers
- 772 people
- Sponsor
- University Hospital, Strasbourg, France
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine