Clinical trials: Persistent Obesity
Low Back Pain
A Combined Lifestyle Intervention Delivered by Physio/exercise Therapists for Patients with Persistent Low Back Pain and Overweight or Obesity
Low back pain (LBP) is the leading cause of disability worldwide and is costly. Lifestyle factors, such as physical inactivity, stress, sleep, excess weight, and an unhealthy diet contribute to the burden of LBP and the…
- Trial name
- Back2Health (NCT06594796)
- Testing
- Combined lifestyle intervention and LBP care (physiotherapy, exercise therapy)
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- Willeke Boonstra
Obesity, Chronic Pain
Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Chronic Pain, Abdominal Pain
- Trial name
- Chron Pain LSG (NCT06686875)
- Testing
- Questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Obesity, Type2diabetes
Susceptibility to Infectious Diseases in Obesity
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology".
- Conditions
- Obesity, Type2diabetes, Gut Microbiota, Chronic Disease
- Trial name
- SIDERALE (NCT05975541)
- Testing
- Observational
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Asthma
Moderate to Persistent Asthma in the Obese Subject
Obesity is associated with increased airway inflammation and asthma severity that results in suboptimal control of asthma despite therapy with high dose inhaled corticosteroids (ICS).
- Trial name
- NCT01016847
- Testing
- Montelukast, Sugar pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Clinically Severe Obesity, Obesity Recidivism
Adding Malabsorption for Failed Gastric Bypass
The main aim of this study is to analyze and report the preliminary and intermediate term outcomes after laparoscopic revision Roux-en-Y gastric bypass surgery for weight recidivism.
- Conditions
- Clinically Severe Obesity, Obesity Recidivism, Inadequate Initial Weight Loss, Poor Weight Loss
- Trial name
- NCT01040481
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, San Francisco
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Bariatric Surgery Candidate
Persistent Organic Pollutants and Mechanical Discharge: Limiting the Impact of Bariatric Surgery Through Personalized Adapted Physical Activity
For the most severe cases of obesity, recourse to bariatric surgery is the ultimate solution. Although highly beneficial to individual health, this massive loss of body mass could also have negative effects on metabolism and…
- Trial name
- PERSIST-APA (NCT06597617)
- Testing
- Adapted physical activity with aerobic training [GEA], Adapted physical activity with strength training [GRM]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Overweight, Obesity
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background…
- Trial name
- ENLIGHTEN-6 (NCT07392190)
- Testing
- Eloralintide
- Where
- 185 sites in United States, Australia and 12 more
- Volunteers
- 900 people
- Sponsor
- Eli Lilly and Company
Persistent Postsurgical Pain, Arthritis Knee
Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
The study is a nationwide, register-based cohort survey study. The objective of this study is to investigate whether weight change is associated with the incidence of persistent postoperative pain following total hip arthroplasty…
- Conditions
- Persistent Postsurgical Pain, Arthritis Knee, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT06024161
- Testing
- Weight gain, Weight loss, Weight unchanged
- Volunteers
- 6,400 people
- Sponsor
- Bispebjerg Hospital
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity, Abdominal, Diabetes
Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients
Environmental endocrine disruptors (EDCs) represent a major problem for human health.Some PEEs can accumulate in the fatty tissue of the human body thanks to their lipophilic nature, and are known as persistent organic pollutants…
- Conditions
- Obesity, Abdominal, Diabetes, Bariatric Surgery Candidate
- Trial name
- OBESE (NCT05966727)
- Testing
- Cholestyramine Powder
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Obesity, Metabolic Syndrome
Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants
Obesity represents one of the most important public health challenges for the societies. Although excess energy intake and physical inactivity are major causes of obesity and cardiometabolic disorders, emerging evidence has…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT02589756
- Testing
- The fatty fish group, The nut group, The control group
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Obesity Hypoventilation Syndrome
Target Volume Mode Controlled Ventilator in Obesity Hypoventilation Syndrome
The purpose of this study is to investigate the evolution of daytime partial pressure of carbon dioxide in the blood (PaCO2) after 6 weeks of noninvasive ventilation-pressure support ventilation (NIV-PSV) with target volume…
- Trial name
- OVO (NCT01104610)
- Testing
- Breas Vivo 40
- Where
- 2 sites in France
- Sponsor
- Breas Medical S.A.R.L.
Diabetes Mellitus, Type 2, Obesity
CARAT: Canagliflozin vs. Placebo for Post Bariatric Patients With Persistent Type 2 Diabetes
This is a prospective, randomized clinical trial for patients with recurrent type 2 diabetes post-gastric bypass surgery that will compare a 6 month course of canagliflozin monotherapy vs.
- Trial name
- NCT02912455
- Testing
- canagliflozin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
Inadequate Initial Weight Loss, Persistent Clinically Severe Obesity
Laparoscopic Revision Gastric Bypass for Inadequate Initial Weight Loss
The main aim of this study is to analyze and report traditional, patient-centered, and composite intermediate-term outcomes after laparoscopic revision Roux-en-Y gastric bypass surgery for inadequate initial weight loss.
- Trial name
- IIWL (NCT01040377)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Hypogonadism, Obesity
Testosterone Replacement Therapy and Liraglutide Effects on Weight Loss in Hypogonadism.
The purpose of this study was to compare the effects of liraglutide and testosterone replacement therapy on features of hypogonadism and weight loss in obese men with persistent features of hypogonadism after unsuccessful…
- Trial name
- NCT03619330
- Testing
- liraglutide, Testosterone
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Child Obesity, Cardiometabolic Health
Evaluating the Impact of a School-based Fruit and Vegetable Co-op on Cardiometabolic Child and Parents Health in a Persistent Poverty Area
The purpose of this study is to examine the effects of the (Brighter Bites (BB) intervention compared to a wait-list control group 9 months after the intervention on changes in primary child outcomes (HbA1c, and vegetable…
- Trial name
- NCT06570707
- Testing
- Brighter Bites
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- The University of Texas Health Science Center, Houston
Atrial Fibrillation Ablation, Persistent Atrial Fibrillation
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
The goal of this clinical trial is to determine whether tirzepatide can reduce atrial fibrillation (AF) burden after catheter ablation in overweight or obese patients with persistent AF.
- Conditions
- Atrial Fibrillation Ablation, Persistent Atrial Fibrillation, Obesity & Overweight
- Trial name
- TREAT-AF (NCT07382024)
- Testing
- Tirzepatide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital