Clinical trials: Persistent Infection
Chronic Obstructive Pulmonary Disease, Lung Disease
To Evaluate the Effect of AZD3199 on the Electrical Activity in the Heart
The purpose of this research study is to evaluate the effect of AZD3199 on the electrical activity of the heart. The effect of AZD3199 will be compared to a licensed antibiotic (moxifloxacin).
- Trial name
- NCT01222442
- Testing
- AZD3199, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic HIV-1 Infection
Towards HIV Functional Cure
During the ERAMUNE-01 and -02 studies, the HIV-DNA quantification in the PBMCs (Peripheral Blood Mononuclear Cells) showed showed that some patients had a very low or undetectable reservoir.
- Trial name
- ULTRASTOP (NCT01876862)
- Testing
- Antiretroviral treatment interruption
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Objectif Recherche Vaccins SIDA
Skin Cancer, Mucosal Neoplasm of Oral Cavity
Retreatment With Intratumoral Diffusing Alpha Radiation Emitters
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for superficial cutaneous, mucosal or soft tissue neoplasia
- Conditions
- Skin Cancer, Mucosal Neoplasm of Oral Cavity, Soft Tissue Neoplasm
- Trial name
- NCT04540588
- Testing
- Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Alpha Tau Medical LTD.
Post-COVID-19 Syndrome, Dyspnea
Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea
To evaluate the extent to which a 12-week respiratory rehabilitation program consisting of inspiratory and expiratory breathing exercises compared to expiratory breathing exercises alone will help to improve shortness of breath…
- Trial name
- NCT06091280
- Testing
- Respiratory Muscle Strength Trainers
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of South Florida
HIV-1 Infection
Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection
The purpose of this research study is to 1) evaluate the safety of a series of injections with the AGS-004 product in combination with a series of Vorinostat doses and 2) to help scientists evaluate ways of reactivating latent…
- Trial name
- VORVAX (NCT02707900)
- Testing
- Vorinostat, AGS-004
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Drug Safety
A Trial to Assess the Safety, Tolerability and Pharmacokinetics of MDT-637 in Subjects With Intermittent, or Mild-to-Moderate Persistent, Asthma
The purpose of this study is to assess the safety and tolerability of MDT-637, when inhaled by subjects with Intermittent, or Mild-to-Moderate Persistent, Asthma.
- Trial name
- NCT01556607
- Testing
- MDT-637
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MicroDose Therapeutx, Inc
COVID-19, SARS-CoV-2 Infection
Physical and Cognitive Impairments in People Suffering From Long COVID
Of the 1,900,000 Canadians who have been infected by COVID-19, 8 to 15% will continue to experience COVID-19 related symptoms well after 12 weeks. The persistence of such symptoms is now defined as "long COVID" syndrome.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Corona Virus Infection, Physical Disability
- Trial name
- NCT05216536
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Laval University
Cervical Intraepithelial Neoplasia, Cervical Cancer
Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female
This study is to evaluate lot-lot consistency of Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) .
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05426148
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) / Cecolin®
- Where
- China
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
Fungal Infection
Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Caspofungin
The purpose of this study is evaluating the efficacy and safety of generics caspofungin in the treatment of the patients with neutropenic and fever.Another purpose of this study is comparing the pharmacokinetic characteristics of…
- Trial name
- NCT03857399
- Testing
- Caspofungin
- Where
- 6 sites in China
- Volunteers
- 32 people
- Sponsor
- Cttq
Septic Shock Hyperdynamic
ILOPROST in Septic Shock With Persistent Microperfusion Defects (I-MICRO)
Septic shock remains a major cause of death in critically ill patients. Alterations in microcirculation have long been proposed as a key pathophysiological factor of organ dysfunction and death in septic shock patients.
- Trial name
- I-MICRO (NCT03788837)
- Testing
- ILOPROST, NaCl
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Treatment Lyme Disease Syndrome
Ceftriaxone for Post-Treatment Lyme Disease
Lyme disease is a public health crisis in the US. It is estimated that over 400,000 cases occur every year with 10-20% of those infected going on to develop Post-Treatment Lyme disease Syndrome (PTLDS).
- Trial name
- NCT06785402
- Testing
- Ceftriaxone treatment
- Where
- United States
- Sponsor
- Hackensack Meridian Health
COVID-19, SARS-CoV-2
Extended Remdesivir Infusion Combined With Nirmatrelvir/Ritonavir for Persistent SARS-CoV-2 Infection in Immunocompromised Patients
To evaluate the safety and efficacy of extended remdesivir infusion, targeting on immunocompromised individuals who had positive SARS-CoV-2 PCR despite an oral antiviral agent prescription.
- Conditions
- COVID-19, SARS-CoV-2, Immunocompromised
- Trial name
- SARS-CoV-2 (NCT06610643)
- Testing
- combination therapy, SOC
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Persistent HPV16 Infection
Evaluation of NWRD09 for Female Participants With Persistent HPV16 Infection
This is a two-part, phase I/IIa study, intended to evaluate the safety, tolerability, immunogenicity, and efficacy of NWRD09 in female participants with persistent HPV16 infection, and to determine the MTD, and/or RP2D of NWRD09.
- Trial name
- NCT07536282
- Testing
- NWRD09
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Newish Biotech (Wuxi) Co., Ltd.
Covid19, Dyspnea
Prospective Study of Persistent Dyspnea in Recovered COVID-19 Patients
We conducted a national, single center (Hospital Clínico Universitario de Valladolid, Spain, Valladolid), prospective study of patients with prior hospitalization because of COVID-19 who were admitted between March 1st, 2020, and…
- Trial name
- DISCOVID19 (NCT04689490)
- Testing
- Cardiopulmonary exercise test
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital Clínico Universitario de Valladolid
Covid19
Enhancing COVID Rehabilitation With Technology
In March 2020, the World Health Organization (WHO) declared the novel coronavirus (COVID-19) a global pandemic. Ontario has confirmed more than 547,000 cases of COVID-19 since testing began.
- Trial name
- ECORT (NCT05019963)
- Testing
- NexJ Connected Wellness, Usual Care
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Ottawa
Cervical Intraepithelial Neoplasia, Cervical Cancer
Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls (54m)
The primary objective of this study is to evaluate the immuno-persistence (type specific IgG antibody) of the tested vaccine administered in girls aged 9-17 years,comparing to young healthy adults of 18-26 years who received the…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT04704908
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 979 people
- Sponsor
- Jun Zhang
Covid19, Diaphragm Injury
Respiratory Muscle Assesment in COVID-patients Without Hospitalization
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory…
- Trial name
- RMA-COVID-19 (NCT06105450)
- Testing
- Comprehensive assessment of respiratory muscle function.
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- RWTH Aachen University
Sepsis
Project 4B: Lower Extremity Strength Training in ICU Patients
The purpose of this research study is to see if electrical stimulation of the leg muscles will improve strength in patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT02467023
- Testing
- Muscle stimulation with Niveus medical stimulator, measurement of maximal isometric twitch strength, Muscle Biopsy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Covid19, Neurological Injury
Radiofrequency Intervention in Neurological Pathologies Post COVID-19
The sequelae that occur in post-COVID-19 patients are multiple and, at a therapeutic level, these represent a new challenge within the general context of the pandemic that the world is suffering.
- Conditions
- Covid19, Neurological Injury, Olfactory Disorder, Gustatory Agnosia
- Trial name
- NCT04920890
- Testing
- Radiofrequency therapy with manual therapy
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Lung Diseases, Obstructive, Bronchiectasis
THERMotherapy Against Persistent Bacterial LUNG Infections
The aim of this study is to determine whether an intervention with frequent thermotherapy will be able to reduce the amount of colonizing bacteria in the bronchoalveolar lavage sample and eradicate the colonizing bacteria.
- Conditions
- Lung Diseases, Obstructive, Bronchiectasis, Asthma, Copd
- Trial name
- THERMA-LUNG (NCT05351242)
- Testing
- Thermotherapy/sauna bath
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark