Clinical trials: Persistent Infection
Onychomycosis
Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenail
The purpose of the study is to determine whether NB002, 0.25%, and 0.5% are safe and effective in the treatment of distal subungual onychomycosis of the toenail.
- Trial name
- NCT00453271
- Testing
- NB-002, Vehicle control
- Where
- 24 sites in United States, Canada
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- NanoBio Corporation
Corneal Ulcer, Persistent Corneal Epithelial Defect
Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers
The purpose of this open, multicenter pilot trial is to assess the impact of the use of an amniotic membrane on the healing of a persistent epithelial lesion or of a corneal ulcer.
- Trial name
- NCT05172349
- Testing
- LV-Visio-AMTRIX
- Sponsor
- TBF Genie Tissulaire
COVID-19
Pulmonary Rehabilitation Post-COVID-19
The main objective of this pilot study was to evaluate the feasibility, safety, and satisfaction of a remote interdisciplinary PR program delivered using two exercise approaches (video conference and self-directed) on the…
- Trial name
- NCT05003271
- Testing
- Exercise program (virtual/remote)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Septic Shock
TIMP2*IGFBP7 and Transient AKI
Patients with septic shock in the intensive care unit have a high risk to develop acute kidney injury (AKI) and AKI is an independent risk factor of mortality.
- Trial name
- BIOCHECK (NCT03472079)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fungal Infection
Evaluate the Safety and Efficacy of Caspofungin Acetate as Empirical Therapy in Chinese Adults With Persistent Fever and Neutropenia (0991-055)
Registration study
- Trial name
- NCT00548080
- Testing
- MK0991, caspofungin acetate / Duration of Treatment:
- Volunteers
- 131 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Volunteer
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers
The current Phase I clinical trial has been developed to assess the safety and tolerability of the Fluorothyazinone drug used as a single-dose administration and a treatment course in healthy volunteers.
- Trial name
- NCT03205462
- Testing
- Fluorothyazinone 300 mg, Fluorothyazinone 600 mg, Fluorothyazinone 3900 mg
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
COVID-19, Long COVID
CORona (COVID-19) Follow Up Study: Epidemiology, Pathophysiology, Prediction, and Communication
The CORFU study, funded by ZonMW, is a prospective, multiple, cohort study with a maximum follow-up of 24 months after COVID-19.
- Conditions
- COVID-19, Long COVID, Post COVID-19 Condition
- Trial name
- CORFU (NCT05240742)
- Testing
- no intervention, the CORFU study conducts analyses based on data which has been prospectively collected (and aggregated when possible) in 7 existing cohorts
- Where
- Netherlands
- Volunteers
- 4,291 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Persistent COVID-19, B Cell Malignancies
Evaluation of Prevalence and Risk Factors of Persistent COVID-19 in Immunocompromised Patients
Spontaneous international multicenter retrospective and prospective observational study which objective is to evaluate the prevalence and risk factors of persistent SARS-CoV-2 infection within a population of hematology patients…
- Trial name
- PERsiCO (NCT06576102)
- Testing
- Persisting SARS-CoV-2 infection
- Where
- 5 sites in Italy, Spain
- Volunteers
- 204 people
- Sponsor
- Maddalena Giannella
Long COVID
PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID
Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called "Long COVID" or Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT07661862
- Testing
- PERCEIVE-Outreach Disease Management Program
- Where
- 2 sites in Australia
- Volunteers
- 577 people
- Sponsor
- University of Tasmania
Chronic Infection
Orange Juice Consumption in Patients With Hepatitis C
This study aimed to verify whether orange juice, source of citrus flavonoids and vitamin C, may contribute to the treatment of patients with chronic hepatitis C.
- Trial name
- NCT03026569
- Testing
- Orange juice (500 mL/d)
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- São Paulo State University
Post-Acute COVID-19 Syndrome
Stem Cell Study for Long COVID-19 Neurological Symptoms
The purpose of this research study is to test the safety and benefit of a human cord blood derived stem cell infusion as a treatment for individuals with post COVID-19 neurological problems.
- Trial name
- COVID-19 (NCT06156241)
- Testing
- Stem Cell
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Charles Cox
SARS-CoV-2 Acute Respiratory Disease
Study of the Evolution of Olfactory Disorders in Patients With Persistent Loss of Smell Following COVID-19
The COVID-19 pandemic is a novel medical challenge, particularly because of the systemic nature of this disease. Indeed, COVID-19 affects several organs and systems at once.
- Trial name
- ETOC (NCT05133596)
- Testing
- Clinical examination, Blood collection, Olfactory evoked potentials
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Pasteur
Post-Acute COVID-19 Syndrome, Dysautonomia
Physiotherapy for Persistent Function by Superficial Neuromodulation
Objectives: To evaluate pressure pain thresholds, fatigue scales, quality of life and sleep quality, in women with Persistent Covid (PC), pre- and post-treatment using electrotherapy and in a placebo group of PC patients.
- Conditions
- Post-Acute COVID-19 Syndrome, Dysautonomia, Neuromodulation
- Trial name
- NCT05681455
- Testing
- Neuromodulation NESA NXSIGNAL® device
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidad Rey Juan Carlos
Cystic Fibrosis, Aspergillus Infections
ATCF (Azole Therapy in Cystic Fibrosis)
Aspergillus infection is an infectious complication which frequently occurs in cystic fibrosis. The efficacy of azole therapy in patients with cystic fibrosis with persistent positive sputums for Aspergillus is still unknown.
- Trial name
- ATCF (NCT01576315)
- Testing
- Itraconazole/voriconazole
- Where
- 15 sites in France, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Lymphatic Disease, HIV Infections
The Efficacy and Safety of Retrovir in Patients Infected With HIV Who Are Asymptomatic (CDC Group II) or Have Persistent Generalized Lymphadenopathy (CDC Group III)
To evaluate the safety and tolerance of chronic administration of Retrovir (AZT) in HIV-infected adult patients without clinical manifestations of disease.
- Trial name
- NCT00002048
- Testing
- Zidovudine
- Where
- 22 sites in United States
- Sponsor
- Glaxo Wellcome
Post-Acute COVID-19 Syndrome
Role of OMT in the Management of the Persistent Post-COVID-19 Symptoms
The goal of this observational study is to determine the feasibility of conducting a large-scale study on the effect of using osteopathic manipulative treatment (OMT) to treat patients with post-COVID-19 symptoms.
- Trial name
- ROMPS (NCT06016543)
- Testing
- osteopathic manipulative treatment (OMT)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- A.T. Still University of Health Sciences
Cervical Cancer Screening, HPV Infection
Risk of Cervical Cancer Following Incident, Persistent and History-unknown HPV Detection
The goal of this register-based retrospective observational study is to understand the risk of cervical cancer following incident, persistent and history-unknown HPV detection by HPV genotype in healthy women participating in…
- Trial name
- NCT07850128
- Testing
- No Intervention: Observational Cohort
- Where
- Sweden
- Volunteers
- 130,000 people
- Sponsor
- Karolinska Institutet
Sepsis
Project 4A: Inspiratory Muscle Training and Diaphragm Strength
Investigators will assess the effect of exercise on markers of inflammation and protein catabolism. This research study will further our understanding of how treating Chronic Critical illness (CCI) - related respiratory muscle…
- Trial name
- NCT02367170
- Testing
- Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
COVID - 19
Persistent COVID-19 Symptoms in Minia
Objective This study aims to identify the nature and prevalence of persistent symptoms in patients discharged from Minya University hospitals in Egypt after recovery from COVID-19, the severity of these symptoms, and the possible…
- Trial name
- NCT06787755
- Where
- Egypt
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville