Clinical trials: Persistent Infection
Sepsis
PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- PICS (NCT02276417)
- Testing
- Blood collection, Urine collection, Bioimpedance Analysis
- Where
- United States
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Florida
HIV Infections
A Test of Behavioral Intervention for Women at High Risk for HIV Infection
The purpose of this study is to find out if it is possible to conduct a group counseling program for women at risk for HIV infection. Women have been the fastest-growing group with new AIDS diagnoses.
- Trial name
- NCT00006440
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis C Infection
Study of a New MVA Vaccine for Hepatitis C Virus
The study is aimed at assessing the safety of AdCh3NSmut and the new candidate vaccine MVA-NSmut when administered sequentially, or alone, to healthy volunteers and patients with hepatitis C virus infection The study also aims at…
- Trial name
- NCT01296451
- Testing
- MVA-NSmut, AdCh3NSmut, AdCh3NSmut1
- Where
- 3 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- ReiThera Srl
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Post-COVID-19 Syndrome
Biomarker Analysis in Post-COVID Patients
Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system.
- Trial name
- NCT05836428
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Neuroborreliosis, Lyme, Quality of Life
Impact on the Quality of Life and Persistent Symptoms of Patients Away From Diagnosed and Treated Neuroborreliosis
The link between Lyme neuroborreliosis (NBL) and persistent symptoms is debated in the medical world. Some report a frequency of post NBL symptoms similar to the general population, and others define a specific entity, the PTLDS…
- Trial name
- QoLyme (NCT05742139)
- Testing
- Non intervention
- Where
- 2 sites in France
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Hopital Nord Franche-Comte
Long COVID, Chronic Pain
Characterization of Long Covid Pain in Primary Care
Justification: among the sequelae of Covid-19 in clinical practice we frequently find persistent neuromusculoskeletal pain. Prevalence data and the underlying mechanisms of such pain are very limited in the scientific literature.
- Conditions
- Long COVID, Chronic Pain, Musculoskeletal Pain
- Trial name
- NCT05894642
- Testing
- 0
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Cancer of Cervix, Vaccinia
The Prospective Cohort Study to Evaluate the Preventive Efficacy of HPV Vaccine in Japanese Women Aged 27-45 Years
A nonrandomized, non-double blinded prospective cohort study to evaluate the preventive efficacy of quadrivalent HPV6/11/16/18 vaccine for the persistent infection of HPV16 genotype or HPV18 genotype in Japanese women aged 27-45…
- Trial name
- NCT04022148
- Testing
- Gardasil
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- University of Fukui
Corona Virus Infection
Persistence of Symptoms After Improvement of Acute COVID-19
Coronavirus disease pandemic has been started in late 2019. Survivors of COVID-19 are significantly more likely to develop clinical sequelae three months after discharge from the hospital than those without COVID-19 infection.
- Trial name
- COVID-19 (NCT04764773)
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Sohag University
Staphylococcal Infections
Evaluation of an Algorithm for Identifying Persistent Nasal Staphylococcus Aureus Carriage in a Cohort of Healthy Volunteers and Patients Regularly Monitored at the CHU of Saint-Etienne
The nasal carriage of Staphylococcus aureus is a major risk factor of S. aureus infection, notably in hemodialysis patients (HPs). Decolonization strategies were shown able to reduce the rate of S.
- Trial name
- ScreenStaph (NCT02557568)
- Testing
- Staphylococcus aureus carriage
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cervical Intraepithelial Neoplasia, Cervical Cancer
Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female
This study is to evaluate lot-lot consistency of Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) .
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05426148
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) / Cecolin®
- Where
- China
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
HIV-1 Infection
Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection
The purpose of this research study is to 1) evaluate the safety of a series of injections with the AGS-004 product in combination with a series of Vorinostat doses and 2) to help scientists evaluate ways of reactivating latent…
- Trial name
- VORVAX (NCT02707900)
- Testing
- Vorinostat, AGS-004
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
SARS-CoV-2, COVID-19
Rapid Diagnostic Profiling of SARS-CoV-2 (COVID-19)
The investigators will evaluate the profile of the immune response of Ethiopian population and examine its relationship with the noted low CD4+ T-cell count and underlying immune activation status among participants with COVID-19…
- Trial name
- Profile-Cov (NCT04473365)
- Testing
- Intestinal parasite
- Where
- Ethiopia
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- Mekelle University
Onychomycosis
Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenail
The purpose of the study is to determine whether NB002, 0.25%, and 0.5% are safe and effective in the treatment of distal subungual onychomycosis of the toenail.
- Trial name
- NCT00453271
- Testing
- NB-002, Vehicle control
- Where
- 24 sites in United States, Canada
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- NanoBio Corporation
Cervical Intraepithelial Neoplasia, Cervical Cancer
Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls
The primary objective of this study is to evaluate the immuno-persistence (type specific IgG antibody) of the tested vaccine administered in girls aged 9-17 years ,comparing to young healthy adults of 18-26 years who received the…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT03206255
- Testing
- 3 doses of HPV 16/18 bivalent vaccine, 2 doses of HPV 16/18 bivalent vaccine
- Where
- China
- Volunteers
- 940 people, healthy volunteers welcome
- Sponsor
- Jun Zhang
Cervical Intraepithelial Neoplasia (CIN), Cervical Cancer
Correlation Between Selenium Levels in Human Tissues and HPV-related Cervical Lesions and Outcomes
This study investigates the relationship between selenium levels in human tissues and the persistence of HPV (human papillomavirus) infection, particularly focusing on cervical-related lesions.
- Conditions
- Cervical Intraepithelial Neoplasia (CIN), Cervical Cancer, Persistent HPV Infection
- Trial name
- SeHPV (NCT06665841)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Human Papillomavirus, Cervical Intraepithelial Neoplasia
Evaluating the 2-dose Immunization Schedule of Human Papillomavirus (HPV)-16/18 in Adolescent Females
To evaluate the immune non-inferiority, as measured by antibody responses, of a 2-dose immunization schedule (0, 6 months) of recombinant human papillomavirus virus-like particle vaccine (type 16 and 18 L1 proteins, yeast)…
- Conditions
- Human Papillomavirus, Cervical Intraepithelial Neoplasia, Persistent Infection
- Trial name
- NCT02740777
- Testing
- HPV-16/18 vaccine
- Where
- 2 sites in China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
HPV-Related Squamous Cell Carcinoma
Persistent Cervical HPV Infection With Clearance and Vaginal Microbiota
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the persistence infection and clearance of HPV infection.
- Trial name
- NCT03895866
- Testing
- The participants were assigned to different groups according to the results of HPV detection.
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cervical Intraepithelial Neoplasia, Cervical Cancer
Long-term Effectiveness and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Preadolescent Girls
The primary objective of this study is to evaluate the protective efficacy against future infections of HPV types 16/18 or related diseases and immuno-persistence (type specific IgG antibody) of the bivalent HPV vaccine in young…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Persistent Infection
- Trial name
- NCT06243666
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli), No intervention
- Where
- China
- Volunteers
- 2,188 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Covid19, Neurological Injury
Radiofrequency Intervention in Neurological Pathologies Post COVID-19
The sequelae that occur in post-COVID-19 patients are multiple and, at a therapeutic level, these represent a new challenge within the general context of the pandemic that the world is suffering.
- Conditions
- Covid19, Neurological Injury, Olfactory Disorder, Gustatory Agnosia
- Trial name
- NCT04920890
- Testing
- Radiofrequency therapy with manual therapy
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon