Clinical trials: Persistent Infection
HIV Infections
Raltegravir Augmentation on Persistent Central Nervous System (CNS) Immunoactivation in Treated HIV-1 Patients
This pilot study focuses on the persistence of central nervous system (CNS) immune activation that has been observed in the presence of 'effective' combination antiretroviral therapy (cART).
- Trial name
- NCT00672932
- Testing
- raltegravir
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Locally Advanced Cervical Cancer, Prognostic Biomarker
Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors
Cervical cancer is strongly associated with HPV infection, yet current post-treatment follow-up relies on cytology and imaging, which have limited accuracy, particularly after radiotherapy.
- Trial name
- ANIHTA (NCT07600515)
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Persistent HR-HPV Infection of the Cervix
Single-arm, Prospective Study of the Efficacy and Safety of Paiteling®Antibacterial Liquid in the Treatment of Persistent Cervical HR-HPV Infection
The effectiveness of Patellin ® antibacterial solution in treating persistent cervical HR-HPV infection
- Trial name
- NCT07493824
- Testing
- Patling ® Antibacterial Liquid
- Where
- China
- Volunteers
- 115 people
- Sponsor
- The First Hospital of Jilin University
Malaria,Falciparum, Malaria
CHILD (Child Health and Infection With Low Density) Malaria
This trial will assess the long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania
- Trial name
- NCT05567016
- Testing
- Active case detection using molecular testing (ACDm), Passive case detection using molecular testing (PCDm), Control (standard of care)
- Where
- Tanzania
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HPV-Related Cervical Carcinoma
HPV Immunological Markers of Cervical Persistent Infection and Oncogenesis
The aim of this observational study is to build an immunological assay to quantify an immunoscore system for clinical practice, which could identify HPV lesions with a risk of persistent cervical infection, which represents the…
- Trial name
- HPVImmuno (NCT06339684)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
HPV-Related Cervical Carcinoma, Low-Grade Squamous Intraepithelial Lesions
Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection
Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.
- Conditions
- HPV-Related Cervical Carcinoma, Low-Grade Squamous Intraepithelial Lesions, HPV Infection, Photodynamic Therapy
- Trial name
- NCT06052033
- Testing
- CO2
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
COVID-19, Fatigue
Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence
The pandemic caused by SARS-CoV-2 infection has resulted, in addition to the well-known acute symptoms, in the emergence of persistent, diffuse and heterogeneous symptoms referred to as persistent COVID.
- Conditions
- COVID-19, Fatigue, Distress Respiratory Syndrome, Cognitive Dysfunction
- Trial name
- DICOPERIA (NCT05629793)
- Testing
- Experimental tests
- Where
- 7 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Fundacin Biomedica Galicia Sur
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Severe Sepsis, Persistent Hypotension
Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France
The epidemiology of this study aims and outcome of patients with septic shock in the intensive care unit (or versatile) of the North-East region in france as well as the modalities of care.
- Trial name
- NCT01903746
- Volunteers
- 1,495 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
MRSA Bloodstream Infection, MRSA Bacteremia
Expanded Access Study of Exebacase in COVID-19 Patients With Persistent MRSA Bacteremia
This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI)…
- Conditions
- MRSA Bloodstream Infection, MRSA Bacteremia, MRSA Right-sided Endocarditis, Covid19
- Trial name
- NCT04597242
- Testing
- Exebacase
- Where
- 2 sites in United States
- Sponsor
- ContraFect
Nasal Obstruction Present Finding
Effectiveness of Oxymetazoline Added on Nasal Steroid in Rhinitis With Persistent Nasal Obstruction
Background Allergic rhinitis is a common health problem with a worldwide prevalence is 10-25%, and poses significant impact on the quality of life of the patients.
- Trial name
- NCT01847131
- Testing
- oxymetazoline
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Rhinitis
Sleep Respiratory Disorders in Patients With Moderate to Severe Persistent Rhinitis
The general aim of this study is to demonstrate that the measurement of respiratory effort assessed by mandibular movements during sleep is a useful measure for the screening of sleep disordered breathing (SDB) in patients with…
- Trial name
- JawRhin1 (NCT04012216)
- Testing
- Measure of mandibular movement using a mid-sagittal magnetic sensor (Brizzy, Jawac©) Nomics, Liege, Belgium), Gold standard: polysomnography
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma
CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial
This study is focused on treatment of anal high-grade squamous intraepithelial lesions (HSIL) in persons with HIV (PWH), with the ultimate goal of applying the approach toward prevention of anal cancer in this population
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma, Anal HSIL
- Trial name
- NCT06949800
- Testing
- EXE-346 Probiotic, Usual Care High Resolution Anoscopy (HRA)
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Children With Cancer, SARS-CoV-2 Infection
Persistent SARS-CoV-2 Infection in Children With Cancer and Impaired Immune Responsiveness
The main goal of this study is to characterize the adaptive immune responses to SARS-CoV-2 infection in a cohort of children with cancer and impaired immune responsiveness and prolonged viral shedding of SARS-CoV-2, and to…
- Trial name
- NCT05172063
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Chronic Infection
Clinical Post-operative Assessment of Chronic Signs & Symptoms Related to Infected Primary Molars After Using Rotary Versus Manual Systems in Cleaning the Root Canals
One of the most important concerns in pediatric dentistry is the loss of necrotic primary molars leading to space loss. pulpectomies for primary teeth with severe pulpal involvement should be considered as the treatment of…
- Trial name
- NCT03684915
- Testing
- Rotary files
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Covid19
Physical Activity and Smell Trainings to Help Individuals With Coronavirus Disease (COVID-19) Recover From Persistent Smell and Taste Impairments - A Pilot Study
The primary objective of this study is to identify efficient treatments to help those with chemosensory losses due to Coronavirus disease (COVID-19).
- Trial name
- CAPS (NCT05037110)
- Testing
- Physical activity, Smell training
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Université de Montréal
Bone and Joint Infection, Staphylococcus Aureus
Prognostic Impact of Delta-haemolysin Production Deficiency in Staphylococcus Aureus on the Prognosis of Infected Implant Treated by DAIR
The aim of this study is to determine if delta-haemolysin production deficiency of Staphylococcus aureus is a marker in favour of chronic infections on implants
- Trial name
- NCT03796104
- Testing
- Delta-haemolysin
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
HPV Infection, HPV Integration
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection.
- Conditions
- HPV Infection, HPV Integration, HPV Disease, HPV Genital Infection
- Trial name
- NCT07697196
- Testing
- Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele