Clinical trials: Peritonitis
Spontaneous Bacterial Peritonitis
Frequency and Predictors of Recurrent SBP in Cirrhotic Patients in Al Rajhi University Hospital
Assess the frequency of recurrent SBP in ascitic cirrhotic patients. Determine the predictive factors of recurrence after the first episode of SBP in ascitic cirrhotic patients
- Trial name
- NCT06778616
- Where
- 2 sites in Egypt
- Volunteers
- 101 people
- Sponsor
- Assiut University
Postoperative Peritonitis
Impact of Rapid Molecular Diagnostic Method on Antibiotics Exposure Duration in ICU Patients with Postoperative Peritonitis
Hospitals, and more specifically Intensive Care Units (ICU), face the challenging issue of emergence and rapid spread of multi-drug resistant bacteria (MDR). In some cases, the therapeutic choice is extremely limited.
- Trial name
- DIRECTABDO (NCT04925388)
- Testing
- rapid molecular diagnosis, conventional method analysis
- Where
- 7 sites in France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peritonitis; Acute, Acute Appendicitis
Retrospective Comparison Between AirSeal® and Standard Insufflation in Appendicular Peritonitis
The AirSeal System Valve-less Trocar is known to decrease postoperative pain, consumption of analgesics, operating time, and length of stay in adults during robotic and laparoscopic procedures.
- Conditions
- Peritonitis; Acute, Acute Appendicitis, Postoperative Pain, Laparoscopy
- Trial name
- APPAS (NCT06734494)
- Testing
- Laparoscopic appendectomy Laparoscopic appendectomy with Airseal or with standard insufflation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Destinval Christelle
Cirrhosis, Spontaneous Bacterial Peritonitis
Early Ascitis Parencentesis in SBP
Paracentesis at 48 hours, as recommended in international guidelines, could delay the time to effective antibiotic therapy in cases of SBP with germs resistant to empirical antibiotic therapy.
- Trial name
- PAPISLA (NCT06679842)
- Testing
- ascitis paracentesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Complicated Appendicitis With Diffuse Peritonitis
Laparoscopic Versus Open Appendectomy Plus Peritoneal Lavage for Acute Complicated Appendicitis Patients With Diffuse Peritonitis
This study aim to evaluate the efficacy and safety of laparoscopic versus open appendectomy in the treatment of acute complicated appendicitis with diffuse peritonitis.
- Trial name
- NCT06633744
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Peritoneal Infection
Intervention to Reduce Infectious Complications of Peritoneal Dialysis
Peritonitis is a common and serious complication of peritoneal dialysis (PD) and is one of the main causes of peritoneal dialysis technique failure and long-term hemodialysis conversion.
- Trial name
- NCT06536673
- Testing
- Intervention to reduce infectious complications of peritoneal dialysis, Data collection from the patient's clinical history
- Volunteers
- 80 people
- Sponsor
- Universitat de Lleida
Liver Cirrhosis, Spontaneous Bacterial Peritonitis
Efficacy of Conventional Dose Protocol vs Low Dose Protocol Albumin Use in Patients With Cirrhosis and High Risk Spontaneous Bacterial Peritonitis
The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined, which decreases the morbidity…
- Trial name
- NCT06026267
- Testing
- 20% High Dose Albumin, Standard Medical Treatment, 20% Reduced Dose Albumin
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Peritoneal Dialysis-associated Peritonitis, Vitamin D Deficiency
Oral Vitamin D Supplementation Prevent Peritoneal Dialysis-related Peritonitis
This is a multicenter randomized, placebo-controlled trial of Vitamin D supplementation in patients on peritoneal dialysis to determine whether oral administration of vitamin D3 after curing an episode of peritonitis could reduce…
- Trial name
- VD-PD (NCT05860270)
- Testing
- Cholecalciferol
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Peking University First Hospital
Peritonitis, Peritonitis Bacterial
Evaluation of Intravenous Dalbavancin for Peritonitis
This study evaluates the use of Dalbavancin 1500 mg IV x 1 dose for treating patients with gram positive peritonitis in patients requiring peritoneal dialysis.
- Trial name
- NCT04624451
- Testing
- Dalbavancin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Peritonitis
Point-of-care Test for Diagnosis of Peritonitis in Peritoneal Dialysis Patients
Peritoneal dialysis (PD) is a home-based dialysis therapy and peritonitis is a serious complication in PD. A reliable point-of-care test to detect peritonitis is important for patients to self-detect peritonitis at home as…
- Trial name
- Periplex (NCT04070196)
- Testing
- Periplex
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore General Hospital
Peritonitis
Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients
To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.
- Trial name
- NCT01785641
- Testing
- ceftazidime+ciprofloxacin, ceftazidime monotherapy, cefazolin+gentamicin
- Where
- Thailand
- Volunteers
- 300 people
- Sponsor
- Chulalongkorn University
Peritoneal Dialysis-associated Peritonitis
Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis
Biofilm formation is an important cause of catheter-related infection. In hemodialysis, use of an antibiotic-lock has been proven to be effective to manage such a complication with preservation of the central venous catheter.
- Trial name
- NCT05971537
- Testing
- antibiotic lock, conventional IP antibiotics
- Where
- Hong Kong
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Alice Ho Miu Ling Nethersole Hospital
Spontaneous Bacterial Peritonitis
Rifaximin as a Prophylaxis of Spontaneous Bacterial Peritonitis in Comparison With Ciprofloxacin
The goal of this Randomized controlled trial is to assessment the efficacy of Rifaximin as a prophylaxis of SBP in comparison with ciprofloxacin in Egyptian patients.
- Trial name
- NCT06234046
- Testing
- Rifaximin 550Mg Tab, Ciprofloxacin 750 MG, ascitic fluid sample
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Peritonitis
Lavage With Super-Oxidized Solution for Secondary Peritonitis
Secondary peritonitis is a frequent abdominal emergency that is still associated with a high morbidity and mortality rate due to surgical site infections (SSI) and sepsis.
- Trial name
- SOSPeritonitis (NCT05050253)
- Testing
- Super-oxidized solution (SOS), Ringer's solution
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Spontaneous Bacterial Peritonitis
Efficacy of Rifaximin vs Norfloxacin for Secondary Prophylaxis of SBP (NORRIF Trial)
SBP is a common complication of cirrhotics with associated increased mortality. After first episode of SBP there is increased risk of again developing SBP, with increased chance of developing resistant organism.
- Trial name
- NCT06199843
- Testing
- Rifaximin, Norfloxacin
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock, Peritonitis
Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™
Sepsis is a major cause of death in Intensive Care Units and therefore finding new therapies to improve survival rates and limit morbidity is a major goal.
- Trial name
- ECRO (NCT03426943)
- Testing
- Arterial blood sampling, Ultrafiltrate sampling, CVVH using oXiris™ filter
- Where
- 8 sites in France
- Volunteers
- 39 people
- Sponsor
- Hospices Civils de Lyon
Spontaneous Bacterial Peritonitis
Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis
A multicentre, interventional, double-blind, placebo-controlled, parallel-arm, phase 3, randomised controlled trial to evaluate the use of co-trimoxazole as primary prophylaxis for spontaneous bacterial peritonitis to improve…
- Trial name
- ASEPTIC (NCT04395365)
- Testing
- Co-Trimoxazole 960Mg Dispersible Tablet
- Where
- United Kingdom
- Volunteers
- 442 people
- Sponsor
- University College, London
Acute Appendicitis Without Peritonitis, Medical Emergencies
Immature Granulocyte [IG] Count and Percentage for Medical Treatment of Uncomplicated Acute Appendicitis
After appendectomy was first described by Mcburney in 1889, it has been the most practiced emergency surgery in the world with the lifetime incidence of acute appendicitis being 5%-25%.
- Trial name
- [IG] (NCT04462588)
- Testing
- Cipro 400 MG in 200 ML Injection, Flagyl I.V. RTU, appendectomy (open or laparascopic)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Postoperative Pain
Effects of Perioperative Administration of Intravenous Lidocaine in Children Operated on for Acute Generalized Peritonitis
Intravenous administration of lidocaine perioperatively after laparotomy for peritonitis could be an interesting alternative by reducing the duration of postoperative ileus, the intensity of pain and the patient's hospital stay…
- Trial name
- NCT06051630
- Testing
- Lidocaine intravenous, Serum saline intravenous
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Université NAZI BONI