Clinical trials: Peritoneal Inflammation
Hernia, Ventral, Laparoscopy
Peritoneal Bridging in Laparoscopic Ventral Hernia Repair
Laparoscopic ventral hernia repair (VHR) is usually performed by reducing the contents in the hernia sac from the abdominal cavity and then covering the defect from the inside with a mesh, i.e. Intraperitoneal Onlay Mesh (IPOM).
- Conditions
- Hernia, Ventral, Laparoscopy, Seroma
- Trial name
- BriClo (NCT03344575)
- Testing
- Conventional defect closure, Peritoneal bridging
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Intra Abdominal Infections, Candidiasis, Invasive
Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)
New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC.
- Conditions
- Intra Abdominal Infections, Candidiasis, Invasive, Peritoneal Candidiasis, Critically Ill
- Trial name
- pBDG2 (NCT03997929)
- Testing
- 1.3 BETA D GLUCAN
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Secondary Peritonitis, Post-induction Hypotension
Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis
This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis.
- Trial name
- NCT07529795
- Testing
- Norepinephrine (0.05 μg/kg/min)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Bach Mai Hospital
Spontaneous Bacterial Peritonitis
Meropenem vs Cefotaxime as Empirical Treatment of SBP
We aimed to evaluate whether meropenem is superior to cefotaxime for treatment of SBP empirically.
- Trial name
- NCT05427747
- Testing
- cefotaxime
- Volunteers
- 286 people
- Sponsor
- Assiut University
Peritonitis, Septic Shock
Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock
The purpose of this randomized, comparative, open and multi-centre study is to show that two sessions of hemoperfusion with Toraymyxin performed within maximum 36 hours after the surgery of a peritonitis by hollow organ…
- Trial name
- ABDO-MIX (NCT01222663)
- Testing
- standard therapy, hemoperfusion
- Where
- 18 sites in France
- Volunteers
- 243 people
- Sponsor
- Meditor SAS
Peritonitis, Critical Illness
Serum and Peritoneal Concentration in Antibiotics During the Surgical Management of Peritonitis
SPAC is a pilote monocentric prospective study about peritonitis and antibiotics pharmacokinetic and pharmacodynamic. The investigators will included 50 patients during 2 years in the University Hospital of Nancy.
- Trial name
- SPAC (NCT03310606)
- Testing
- Dosage of serum and peritoneal of the B lactam used for antibiotic treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
SBP - Spontaneous Bacterial Peritonitis
N-Acetylcysteine in the Management of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is one of the most serious infectious complications of liver cirrhosis and ascites. It affects approximately 10-30% of hospitalized patients with decompensated cirrhosis and carries an…
- Trial name
- NCT07803952
- Testing
- NAC
- Volunteers
- 60 people
- Sponsor
- Tanta University
Peritoneal Dialysis-associated Peritonitis, Peritoneal Dialysis (PD)
Pharmacokinetics of Intraperitoneal and Intravenous Meropenem, Ampicillin, Aztreonam and Ciprofloxacin in Automated Peritoneal Dialysis Patients Without Peritonitis
This study aims to investigate the pharmacokinetics (PK) and pharmacodynamic (PD) profiles of four commonly used antibiotics - meropenem, ampicillin, aztreonam, and ciprofloxacin - administered via intravenous (i.v.) and…
- Conditions
- Peritoneal Dialysis-associated Peritonitis, Peritoneal Dialysis (PD), Pharmacokinetics, Intravenous Administration
- Trial name
- NCT07113587
- Testing
- Application of intraperitoneal and intravenous meropenem in in automated peritoneal dialysis patients without peritonitis, Application of intraperitoneal and intravenous ampicillin in automated peritoneal dialysis patients without peritonitis, Application of intraperitoneal and intravenous aztreonam in automated peritoneal dialysis patients without peritonitis
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karl Landsteiner Insitute for Nephrology and Haemato-Oncology
Hearing Loss, Extreme
Protective Effect of N-acetylcysteine Against From Ototoxicity
Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD). Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for…
- Trial name
- NCT01271088
- Testing
- N-acetylcysteine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
End Stage Renal Disease, Peritoneal Dialysis
Chlorhexidine Gluconate Versus Mupirocin Ointment in the Prevention of Peritoneal Dialysis-Related Infection
This pilot study aims to evaluate effectiveness, safety, and cost-utility of chlorhexidine gluconate (CHG)-soaked cloths compares to mupirocin ointment and exit site usual care (normal saline) with aseptic technique in prevention…
- Trial name
- COSMO-PD (NCT02547103)
- Testing
- Chlorhexidine gluconate-soaked cloths, Normal saline, mupirocin ointment
- Where
- Thailand
- Volunteers
- 354 people
- Sponsor
- Chiang Mai University
Peritoneal Infection
Intervention to Reduce Infectious Complications of Peritoneal Dialysis
Peritonitis is a common and serious complication of peritoneal dialysis (PD) and is one of the main causes of peritoneal dialysis technique failure and long-term hemodialysis conversion.
- Trial name
- NCT06536673
- Testing
- Intervention to reduce infectious complications of peritoneal dialysis, Data collection from the patient's clinical history
- Volunteers
- 80 people
- Sponsor
- Universitat de Lleida
Peritonitis Infectious, Gastrointestinal Perforation, Surgical Infection, Postoperative Complications
Predictors of Morbidity in Perforation Peritonitis: A Prospective Observational Study From a Tertiary Care Centre in North India
This is a prospective observational cohort study conducted at a tertiary care hospital in North India. The study aims to evaluate clinical and biochemical predictors of postoperative morbidity in patients undergoing emergency…
- Trial name
- PERIMOPP (NCT07047911)
- Testing
- Observational only - surgical management not assigned by study
- Volunteers
- 50 people
- Sponsor
- Government Medical College, Patiala
Cirrhosis
Predictors of Spontaneous Bacterial Peritonitis Among Patients with Cirrhosis
Prevalence of spontaneous bacterial peritonitis (SBP) varies from approximately 4% among asymptomatic patients to 30% among those hospitalized [1, 2].Previous studies explored the role of several biomarkers, such as tumor…
- Trial name
- NCT06884306
- Volunteers
- 200 people
- Sponsor
- Assiut University
End Stage Renal Disease, Peritoneal Dialysis-associated Peritonitis
A Prospective Clinical Study to Assess the Clinical Utility of Turbidity in Patients Using In-Home Peritoneal Dialysis
This study aims to determine if the CloudCath device can detect infections related to peritoneal dialysis (peritonitis) as fast or faster than the current standard methods used by patients and doctors to detect such infections.
- Conditions
- End Stage Renal Disease, Peritoneal Dialysis-associated Peritonitis, Peritonitis
- Trial name
- ACT (NCT05285436)
- Testing
- CloudCath System
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- CloudCath
Peritoneal Dialysis-associated Peritonitis, Vitamin D Deficiency
Oral Vitamin D Supplementation Prevent Peritoneal Dialysis-related Peritonitis
This is a multicenter randomized, placebo-controlled trial of Vitamin D supplementation in patients on peritoneal dialysis to determine whether oral administration of vitamin D3 after curing an episode of peritonitis could reduce…
- Trial name
- VD-PD (NCT05860270)
- Testing
- Cholecalciferol
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Peking University First Hospital
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Peritoneal Dialysis Associated Peritonitis
Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis
Intra-peritoneal administration of antibiotics covering both gram-positive and gram-negative organisms was recommended as first-line regimen for the management of peritoneal dialysis related peritonitis.
- Trial name
- PD (NCT02787057)
- Testing
- vancomycin, moxifloxacin, ceftazidime
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Perforated Diverticulitis
Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis
The first objective (LOLA) of this integrated trial is to determine whether laparoscopic lavage leads to better clinical outcomes compared to sigmoidectomy in patients with perforated diverticulitis with purulent peritonitis in…
- Trial name
- Ladies (NCT01317485)
- Testing
- Laparoscopic lavage and drainage, Sigmoidectomy with primary anastomosis, Sigmoidectomy with end-colostomy
- Where
- 41 sites in Belgium, Netherlands
- Volunteers
- 283 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Infection
Assessment of the Safety and Efficacy of Ciproxan-I.V. in Daily Clinical Practice - Analysis Results From a Post-marketing Surveillance
This study is a post-marketing surveillance in Japan, and it is a local prospective and observational study of patients who have received Ciproxan intravenously as a first-line treatment for sepsis, secondary skin infections…
- Trial name
- NCT01670435
- Testing
- Ciprofloxacin (BAYQ3939)
- Where
- Japan
- Volunteers
- 3,274 people
- Sponsor
- Bayer
Infection
Ciprofloxacin Special Drug Use Investigation - To Investigate the Safety and Efficacy in Patients With Ciprofloxacin iv Administration Without Dilution
This study is a post-marketing surveillance in Japan to investigate the safety especially focusing on injection site adverse events and efficacy in patients with Ciprofloxacin iv administration without dilution in the daily…
- Trial name
- NCT01690559
- Testing
- Cipro (Ciprofloxacin, BAYQ3939)
- Where
- Japan
- Volunteers
- 704 people
- Sponsor
- Bayer