Clinical trials: Periprocedural Myocardial Infarction
Acute Coronary Syndrome
Effectiveness of Thrombus Aspiration in Plaque Reduction for Patients With Acute Coronary Syndromes
Although successful, percutaneous coronary interventions (PCI) with stent implantation may be hampered by periprocedural myocardial necrosis.
- Trial name
- REMNANT (NCT01342848)
- Where
- 3 sites in Italy
- Volunteers
- 76 people
- Sponsor
- Raffaele De Caterina
Periprocedural Myocardial Infarction
Ticagrelor in Remote Ischemic Preconditioning Study
Remote ischemic preconditioning (RIPC) reduces periprocedural myocardial injury (PMI) after percutaneous coronary intervention (PCI) through various pathways, including an adenosine-triggered pathway.
- Trial name
- TRIP (NCT04174261)
- Testing
- Ticagrelor, Remote Ischemic Preconditioning, Clopidogrel
- Where
- Greece
- Volunteers
- 245 people
- Sponsor
- Hellenic Society of Interventional Cardiology
Angina, Stable
Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients
The study included 511 patients who underwent PCI because of angina during 2010-2011 at three Korean hospitals. Clopidogrel-naïve patients received either a loading dose (LD; 600 mg at 2-24 h before the procedure) or routine…
- Trial name
- MECCA (NCT03759067)
- Testing
- clopidogrel 75mg, Clopidogrel 300 mg, clopidogrel 600mg
- Volunteers
- 511 people
- Sponsor
- Korea University Anam Hospital
Coronary Thrombosis
Periprocedural Myocardial Infarction: the Role of Human Neutrophil Peptide-1 to 3
The aim of this study is to determine the role of human neutrophil peptide-1 to 3 in the occurrence of periprocedural myocardial infarction.
- Trial name
- NCT02591264
- Testing
- Blood sample
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hillel Yaffe Medical Center
Periprocedural Myocardial Infarction, Periprocedural Myocardial Injury
Colchicine for Reduction of Periprocedural Myocardial Injury in Percutaneous Coronary Intervention
Study of role of colchicine in reducing periprocedural myocardial injury in patients prepared for elective PCI and its role in reduction of MACEs.
- Trial name
- NCT05745818
- Testing
- Colchicine Pill
- Volunteers
- 300 people
- Sponsor
- Sohag University
Assess the Periprocedural Myocardial Necrosis
ROsuvastatin Pretreatment to Reduce MyocArdial Periprocedural Necrosis:Comparison With Atorvastatin Reloading
An increase in cardiac biomarkers has been shown to occur in 5% to 30% of patients after otherwise successful percutaneous coronary interventions (PCIs)(1) Apart from side-branch occlusion, intimal dissection and coronary spasm…
- Trial name
- ROMAIIReload (NCT01228227)
- Testing
- ATORVASTATIN 80 mg, ROSUVASTATIN 40 mg
- Where
- Italy
- Volunteers
- 310 people
- Sponsor
- Gennaro Sardella
Metabolic Syndrome, Coronary Artery Disease
Angiotensin Converting Enzyme Inhibitors and Periprocedural Myocardial Infarction
Metabolic syndrome (MS) has been reported as a risk for cardiovascular events. The aim of the present cohort study is to investigate whether ACEi therapy reduces the rate of periprocedural myocardial injury (PPMI) after elective…
- Trial name
- NCT02054390
- Where
- Turkey (Türkiye)
- Volunteers
- 459 people
- Sponsor
- Ankara University
Coronary Artery Disease
Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention
The aim of this study is to evaluate the effects of N-acetyl cysteine on periprocedural myocardial infarction and major cardiac and cerebral events in patients undergoing percutaneous coronary intervention and who have moderate…
- Trial name
- EASE-PCI (NCT01878669)
- Testing
- N-acetyl cysteine, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 390 people
- Sponsor
- Suleyman Demirel University
Coronary Artery Disease
Bivalirudin Plus Stenting in Long Lesion to Avoid Periprocedural Myocardial Necrosis Trial
Background: Randomized trials show improved outcomes among acute coronary syndrome (ACS) patients treated with Bivalirudin1. Optimal antithrombotic treatment in patients undergoing percutaneous coronary intervention (PCI) is…
- Trial name
- BILLION (NCT01555658)
- Testing
- Bivalirudin, Unfractioned Heparin
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
Troponin Release Induced by Procedure - Czech
A prospective study aiming to analyse the relation between different variables and high sensitivity troponin I (hsTnI) elevation within a group of patients undergoing a coronary angiography with or without subsequent percutaneous…
- Trial name
- TRIP-CZ (NCT02960321)
- Volunteers
- 220 people
- Sponsor
- Tomas Bata Hospital, Czech Republic
Coronary Artery Disease, Coronary Angioplasty
Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention (PCI) Study 2
This study investigates potential protective effect of atorvastatin pre-treatment in patient with stable coronary artery disease undergoing percutaneous coronary intervention (PCI) on chronic statin therapy.
- Trial name
- TIPS-2 (NCT01058057)
- Testing
- atorvastatin
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital, Motol
Aortic Valve Disease, Aortic Valve Stenosis
Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)
Transcatheter aortic valve implantation (TAVI) is a rapidly growing treatment option for patients with aortic valve stenosis. Stroke is a feared complication of TAVI, with an incidence of around 4-5% in the first 30 days.
- Conditions
- Aortic Valve Disease, Aortic Valve Stenosis, Stroke, Bleeding
- Trial name
- NCT04437303
- Testing
- Continuation of oral anticoagulants, Interruption of oral anticoagulants
- Where
- 22 sites in Belgium, Denmark and 4 more
- Volunteers
- 858 people
- Sponsor
- St. Antonius Hospital
Coronary Artery Disease
Ranolazine Loading to Prevent PCI-induced Myocardial Injury
It has previously been shown that pretreatment with ranolazine 1,000 mg twice daily for 7 days can significantly reduce procedural myocardial injury in elective percutaneous coronary intervention (PCI).
- Trial name
- TWILIGHT (NCT01491061)
- Testing
- Ranolazine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
Rosuvastatin Pre-Treatment Influences the Risk of Coronary Intervention Study
The aim of this study is to determine whether a pre-treatment with high-dose statin (one day prior and just before intervention, rosuvastatin 20mg/day) has a positive impact on the occurrence of periprocedural myocardial…
- Trial name
- TIPS-3 (NCT01378715)
- Testing
- Rosuvastatin
- Where
- 4 sites in Czechia, Slovakia
- Volunteers
- 400 people
- Sponsor
- University Hospital, Motol
Non STEMI, Unstable Angina
Safety and Efficacy of CMX-2043 for Protection of the Heart and Kidneys in Subjects Undergoing Coronary Angiography
The objective of this study is to evaluate CMX-2043 for prevention of renal and cardiac injury associated with coronary angiography in patients with acute coronary syndrome (ACS), but excluding ST-elevation myocardial infarction…
- Trial name
- CARIN (NCT02103959)
- Testing
- CMX-2043
- Volunteers
- 361 people
- Sponsor
- Ischemix, LLC
Periprocedural Myocardial Necrosis
Rosuvastatin in Preventing Myonecrosis in Elective Percutaneous Coronary Interventions (PCIs)
An increase in cardiac biomarkers has been shown to occur in 5% to 30% of patients after otherwise successful percutaneous coronary interventions (PCIs)(1) Apart from side-branch occlusion, intimal dissection and coronary spasm…
- Trial name
- ROMA (NCT01007279)
- Testing
- ROSUVASTATIN
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Roma La Sapienza
Inflammation, Myocardial Infarction
Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin
The aim of this research is to study the effect of a loading dose of colchicine on the occurrence of periprocedural myocardial infarction (PPMI) in elective percutaneous coronary intervention.
- Trial name
- NCT03735134
- Testing
- Colchicine Loading Dose, Standard of care treatment prior to elective PCI
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Hillel Yaffe Medical Center
Stable Angina (SA), Unstable Angina (UA)
Breaking Fasts Ahead of Cardiac Caths
The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to…
- Conditions
- Stable Angina (SA), Unstable Angina (UA), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- BACON-RCT (NCT06996639)
- Testing
- Non-Fasting, Fasting
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of South Florida
STEMI - ST Elevation Myocardial Infarction
Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size
This study evaluates differences in the extent of myocardial necrosis noted by cardiac MRI in patients with ST-elevation myocardial infarction randomized to receive cangrelor during their percutaneous coronary intervention and…
- Trial name
- NCT03043274
- Testing
- Cangrelor
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Khaled Ziada, MD
Coronary Angioplasty
Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty
Aim of the study is to evaluate the benefits from adjunctive intracoronary administration of adenosin in elective patients undergoing coronary angioplasty.
- Trial name
- PREVENT-ICARUS (NCT01148147)
- Testing
- Adenosine
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita