Clinical trials: Peripheral Neuropathy With Type 2 Diabetes
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population
The study aims to assess foot complications among patients with diabetes in Canada, using patient data collected during diabetes foot assessments performed by the LMC Chiropody Team between February 27, 2018 and April 17, 2019.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Foot Deformities, Onychauxis
- Trial name
- PEDAL (NCT04327622)
- Where
- Canada
- Volunteers
- 5,084 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Diabetic Neuropathy Peripheral
Effects of BFRT on Glycemic Control, Nerve Conduction, Functional Outcomes and QOL in Individuals With Type 2 Diabetes
Diabetic peripheral neuropathy is one of the most prevalent complications of Type 2 Diabetes Mellitus. Peripheral neuropathy is caused by unavailability of glucose in cells and low metabolism.
- Trial name
- NCT07763795
- Testing
- BFR with low resistance high repetition exercises, low resistance high repetition exercises
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Neuropathic Pain, Diabetes Mellitus, Type 2
A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain
This study is to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.
- Trial name
- NCT05624853
- Testing
- pregabalin sustained release tablet, pregabalin immediate release capsule
- Where
- 8 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Yuhan Corporation
Type 2 Diabetes (Adult Onset), Diabetic Neuropathies
Clinical Study Evaluating the Safety and Efficacy of Roflumilast in Type 2 Diabetic Patients With Diabetic Neuropathy
Evaluation of the side effects and efficacy of roflumilast on glycemic parameters, insulin resistance, oxidative and inflammatory markers in Type 2 diabetic patients with diabetic neuropathy.
- Trial name
- NCT05369793
- Testing
- Alpha lipoic acid, Roflumilast
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Painful Diabetic Neuropathy
Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)
The purpose of this study is to evaluate safety and efficacy of EMA401 compared to placebo in patients with painful diabetic neuropathy (PDN).
- Trial name
- EMPADINE (NCT03297294)
- Testing
- EMA401
- Where
- 64 sites in Australia, Austria and 14 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Microvascular Dysfunction in Diabetic Peripheral Neuropathy
This study primarily seeks to evaluate dysfunction of small blood vessels and their linkage to dysfunction of nerves in people with Type 2 Diabetes.
- Trial name
- NCT05118217
- Testing
- This is a non-interventional study
- Volunteers
- 72 people
- Sponsor
- University of Plymouth
Ultrasonography, Peroneal Neuropathies
High-resolution Ultrasound in Lower Extremity Nerves and Common Fibular Neuropathies.
This study establishes reference material of selected lower extremity nerves at pre-defined sites with high-resolution ultrasound.
- Trial name
- NCT03560505
- Testing
- Ultrasound protocol
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Diabetes Mellitus Type 2 Without Complication, Polyneuropathies, Diabetic
Polyneuropathy in Diabetes Mellitus Type 2
This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2).
- Conditions
- Diabetes Mellitus Type 2 Without Complication, Polyneuropathies, Diabetic, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- NCT02947828
- Where
- 2 sites in Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
The purpose of the study is to study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
- Trial name
- NCT00406458
- Testing
- SB-509, Normal Saline
- Where
- 15 sites in United States, Mexico
- Volunteers
- 110 people
- Sponsor
- Sangamo Therapeutics
Diabetic Neuropathies
Differences In The Severity Of Diabetic Neuropathy Based On Electromyography In Type 2 Diabetes Mellitus Patients With And Without Comorbidities
The goal of this clinical trial is to learn the differences severity level of diabetic neuropathy based on electromyelography in type II diabetic patient with and without comorbidities. The main questions of this study: 1.
- Trial name
- DISNEY-T2DM (NCT06573684)
- Testing
- Electromyography
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Diponegoro
Diabetes Mellitus
Effect of Self-Foot Massage on Diabetic Individuals
The aim of this study is to evaluate the effect of self-foot massage on peripheral neuropathic pain, peripheral skin temperature and patient comfort in individuals with diabetes.
- Trial name
- NCT04906226
- Testing
- Self-foot massage
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Aksaray University
Neuropathic Pain, Type 1 Diabetes Mellitus
Influence of Diabetes on Tramadol Pharmacokinetics
This study aimed to investigate the influence of uncontrolled type 1 and type 2 diabetes mellitus (DM) on the kinetic disposition, metabolism and pharmacokinetics-pharmacodynamics of tramadol enantiomers in patients with…
- Conditions
- Neuropathic Pain, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- NCT02246712
- Testing
- Single oral dose of 100 mg racemic tramadol, CYP2D6 phenotype, CYP3A phenotype
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus
Microcirculatory Vasomotor Changes in Type 2 Diabetes With Peripheral Neuropathy
Microcirculatory flow is subject to cyclic changes under the influence of heart rate, respiration, myogenic activity, neurogenic factors and endothelial factors.
- Conditions
- Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus, Vasodilation, Vasoconstriction
- Trial name
- NEUROMICRO (NCT03847779)
- Testing
- "Rest", "Exercise", "Foot lowering"
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Diabetic Neuropathies
Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes, affecting about 50% of patients with diabetes and leading to severe morbidity, poor quality of life, high mortality, and high health care…
- Trial name
- NCT05169060
- Testing
- Fish Oil Concentrate, 1000 Mg Oral Capsule, Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Diabetic Peripheral Neuropathy Type 2
Treatment With Human Umbilical Cord Mesenchymal Stem Cells for Refractory Diabetic Peripheral Neuropathy
Diabetic Peripheral Neuropathy (DPN) is one of the most common chronic complications in type 2 diabetes, conventional drug therapy can only target a single pathogenesis but not treat Diabetic Peripheral Neuropathy (DPN)…
- Trial name
- NCT05507697
- Testing
- HUC-MSCs, Lipoic Acid
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Wuhan Central Hospital
Diabete Type 2
The Effect of Peripheral Neuropathy Symptoms on Temporomandibular Joint Functionality
The aim of this observational case-control study was to investigate the effect of diabetic peripheral neuropathy symptoms on temporomandibular joint functionality in patients with type 2 diabetes.
- Trial name
- NCT06188572
- Testing
- Michigan Neuropathy Screening Instrument, Numeric Pain Scale, Mandibular Function Disorder Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Painful Diabetic Neuropathy
Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation
Will participants with painful lower extremity diabetic peripheral neuropathy (DPN) that are treated with high frequency spinal cord stimulation (HF10 SCS) have improvements in lower extremity peripheral nerve function?
- Trial name
- NCT03769675
- Testing
- High Frequency Spinal Cord Stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Metabolic Syndrome and Diabetic Neuropathy
Hesperidin and Diosmin Effect on Metabolic Syndrome
The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes.
- Trial name
- NCT05243238
- Testing
- dietary supplement flavonoids
- Where
- Egypt
- Volunteers
- 129 people
- Sponsor
- Beni-Suef University
Diabetic Polyneuropathy
The Effect of Alpha Lipoid Acid and Vitamin B Preparation on Diabetic Polyneuropathy in Type 2 Diabetes Mellitus Patient
To evaluate the efficacy of combination of vitamin B and alpha lipoic acid formulations for the treatment of diabetic polyneuropathy in individuals with type 2 diabetes mellitus.
- Trial name
- NCT06568185
- Testing
- Alpha-Lipoic Acid/Vitamin/Mineral Supplement PolyMVA
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Sains Malaysia