Clinical trials: Perioperative Myocardial Injury
Liver Neoplasm, Kidney Injury, Acute
Perioperative Myocardial and Renal Injury in Patients Undergoing Hepatic Resection
Liver surgeries are high risk surgeries that might result in injuries in kidneys and heart. This study was planned to investigate the frequency of these injuries as well as the risk factors for their devolopment and its effect on…
- Conditions
- Liver Neoplasm, Kidney Injury, Acute, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- NCT06775158
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul Saglik Bilimleri University
Acute Myocardial Infarction
Effect of Perioperative Ultrasound-guided Remote Ischemic Conditioning on Acute Myocardial Infarction
Acute myocardial infarction (AMI) is an event of myocardial necrosis caused by myocardial ischemia. Although the incidence and economic burden of AMI has declined in high-income countries, the incidence rate of AMI in China has…
- Trial name
- NCT05044806
- Testing
- Ultrasound-guided remote ischemic conditioning, Traditional remote ischemic conditioning, Percutaneous coronary intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Perioperative Bleeding, Venous Thrombosis
PeriOperative ISchemic Evaluation-3 Trial
This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance…
- Conditions
- Perioperative Bleeding, Venous Thrombosis, Arterial Thrombosis
- Trial name
- POISE-3 (NCT03505723)
- Testing
- Tranexamic Acid, Perioperative hypotension-avoidance strategy, Perioperative hypertension-avoidance strategy
- Where
- 114 sites in United States, Australia and 21 more
- Volunteers
- 9,535 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Obstructive Sleep Apnea
Perioperative Complications and Myocardial Injury Risk in Arthoplasty Patients Suspected of Having Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is a common and under-diagnosed breathing disorder characterized by recurrent partial or complete collapse of the upper airway (tongue, soft palate) during sleep.
- Trial name
- NCT03281408
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Myocardial Injury
Perioperative Endothelial Dysfunction
More than one in 100 otherwise healthy patients undergoing non-cardiac surgery will die within 30 days post-operatively, and of these patients 45% will die from vascular causes such as myocardial infarction.
- Trial name
- NCT02344771
- Testing
- Elective colon cancer surgery
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Zealand University Hospital
Perioperative Complication, Myocardial Injury
Development of a New Prognostic Assessment Tool for Postoperative Myocardial Injury
Myocardial injury after noncardiac surgery (MINS) is common, silent, and strongly associated with morbi-mortality. There are some evidences in the littérature showing that troponin elevation pre and/or postoperatively and…
- Trial name
- TROPUTILE (NCT04286685)
- Where
- 2 sites in France
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
High Risk Non-cardiac Surgery, Death
Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery
Cerebral desaturations occur frequently in patients undergoing non-cardiac surgery. The definition of what constitutes a cerebral desaturation, the incidence of the phenomenon, the association between desaturations and…
- Conditions
- High Risk Non-cardiac Surgery, Death, Delirium, Kidney Injury
- Trial name
- NCT01838733
- Testing
- Observational study
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University of Manitoba
Myocardial Injury, Perioperative/Postoperative Complications
Comparison Arterial Blood Pressure and Cardiac Index-based Hemodynamic Management on Postoperative Myocardial Injury
The primary aim of this study is to compare mean arterial pressure (MAP) and cardiac index (CI) based intraoperative hemodynamic management in terms of postoperative high sensitive troponin elevation.
- Trial name
- NCT05391087
- Testing
- Mean arterial pressure based management, Cardiac index based management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Saglik Bilimleri University
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Perioperative Myocardial Injury
Incidence and Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery
This observational study includes patients undergoing major non-cardiac surgery, and screens them for the occurrence of perioperative myocardial injuries (PMI).
- Trial name
- BASEL-PMI (NCT02573532)
- Where
- Switzerland
- Volunteers
- 19,645 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Infarction Postoperative, Myocardial Injury
Myocardial Infarction in the Perioperative Setting
Acute myocardial infarction (AMI) is a significant complication following non-cardiac surgery. The investigators sought to evaluate incidence of perioperative AMI, its preoperative and intraoperative risk factors and the outcomes…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- MIPS (NCT03837535)
- Testing
- Surgery
- Where
- Sweden
- Volunteers
- 400,742 people
- Sponsor
- Karolinska University Hospital
Heart Diseases
Metoprolol to Reduce Perioperative Myocardial Injury
The purpose of this research study is to test if a commonly used, FDA-approved medication, called metoprolol, given at the conclusion of anesthesia following surgery, and during postoperative admission, reduces the possibility of…
- Trial name
- ORION (NCT03138603)
- Testing
- Metoprolol Tartrate
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Chicago
Myocardial Injury, Myocardial Injury After Non-Cardiac Surgery
Unraveling Perioperative Myocardial Injury
The aim of this study is to gain insight into the etiology of myocardial injury after non cardiac surgery. Furthermore, suspected etiologies were explored and hierarchically classified into most likely cause how this determines…
- Trial name
- REMAIN (NCT06728111)
- Testing
- High sensitive Troponin T
- Where
- Netherlands
- Volunteers
- 1,114 people
- Sponsor
- Erasmus Medical Center
Myocardial Injury, Acuter Kidney Injury
Impact of Perioperative Allogeneic Red Blood Cell Transfusion on Postoperative Myocardial Injury After Liver Resection
We aimed to explore the influence of ABT on the incidence of MINS, AKI, and overall prognosis among advanced-age HCC patients who underwent hepatectomy
- Trial name
- NCT07125612
- Volunteers
- 487 people
- Sponsor
- Hao Li
Cardiac Ischemia, Cardiac Arrhythmia
Prognostic Value of the Selvester QRS Score for Perioperative Myocardial Injury Following Non-cardiac Surgery
The purpose of this study to determine the prognostic value of the Selvester QRS score for perioperative myocardial injury following elective non-cardiac surgery.
- Conditions
- Cardiac Ischemia, Cardiac Arrhythmia, Perioperative Injury, Perioperative Complication
- Trial name
- NCT05453097
- Testing
- Selvester QRS Score with Preoperative ECG
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul University - Cerrahpasa
Myocardium; Injury, Perioperative/Postoperative Complications
The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery
The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.
- Conditions
- Myocardium; Injury, Perioperative/Postoperative Complications, Angiotensin-Converting-Enzyme Inhibitor
- Trial name
- NCT06862115
- Testing
- ACE-I and/or ARB antihypertensive treatment
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- Kasr El Aini Hospital
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Injury After Non-cardiac Surgery, Submaximal Exercise Performance
Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery
The goal of this clinical trial is to learn whether physicians can associate evidence of myocardial injury after surgery with findings obtained from submaximal cardiopulmonary exercise testing.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Submaximal Exercise Performance, Preoperative Period
- Trial name
- EnhanceMINS (NCT06474754)
- Testing
- High-sensitivity troponin, serum, Submaximal Cardiopulmonary Exercise Testing, Duke Activity Status Index
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Myocardial Injury, Coronary Artery Disease
Perioperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Clinical Study
Perioperative myocardial injury (PMI) following coronary artery bypass grafting (CABG) is associated with postoperative morbidity, mortality, and long-term outcomes.
- Trial name
- NCT07650487
- Testing
- High-Sensitivity Troponin, Cardiac MRI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Hospital of Jilin University