Clinical trials: Perioperative Hemorrhage
Postoperative Blood Loss
Effect of Early Administration of TXA in Adult Hip Fractures
This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center.
- Trial name
- NCT05047133
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ascension Health
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Abdominal Aortic Aneurism, Abdominal Aortic Rupture
Haemostasis Management of Abdominal Aortic Procedures
Comparative study on efficacy of haemostatic therapy guided either by standard laboratory coagulation parameters or point-of-care testing in patients undergoing vascular surgical procedures.
- Conditions
- Abdominal Aortic Aneurism, Abdominal Aortic Rupture, Perioperative/Postoperative Complications, Surgical Blood Loss
- Trial name
- NCT03426839
- Testing
- Coagulation tests
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Blood Loss, Surgical
Non-invasive Perioperative Hb Monitoring in Spinal Surgery
The decision to transfuse or not to transfuse blood products is one of the main issues in patients undergoing surgery. The standard laboratory method of hemoglobin assessment is time-consuming, gives intermittent data, and…
- Trial name
- NCT02908412
- Testing
- Digital nerve block with bupivacaine
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Tehran University of Medical Sciences
Femoral Fractures, Hemorrhage, Surgical
Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery
This clinical study aims to evaluate the safety and effectiveness of administering a single intravenous dose of tranexamic acid (TXA) before surgery to reduce blood loss in patients undergoing open intramedullary nailing for…
- Conditions
- Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use
- Trial name
- TXA-FemNail (NCT07261930)
- Testing
- Tranexamic Acid
- Where
- Uganda
- Volunteers
- 43 people
- Sponsor
- Masaka Regional Referral Hospital
Blood Loss, Postoperative
Perioperative Blood Transfusion in Open Liver Resection
This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.
- Trial name
- NCT06189911
- Testing
- Open liver resection
- Volunteers
- 1,201 people
- Sponsor
- Chiang Mai University
Bleeding, Von Willebrand Disease
Acquired Von Willebrand Syndrome in Severe Aortic Stenosis
Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences.
- Conditions
- Bleeding, Von Willebrand Disease, Aortic Stenosis
- Trial name
- NCT00805051
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Hemorrhage, Hypocalcemia
The No-Tie Technique Using the Harmonic Scalpel in Total Thyroidectomy With Central Neck Dissection: A Prospective Randomized Study
To investigate the safety and efficacy of the no-tie technique using the harmonic scalpel (HS) in terms of the operating time and complications in total thyroidectomy with central neck dissection (CND).
- Conditions
- Hemorrhage, Hypocalcemia, Vocal Cord Palsy
- Trial name
- NCT00506103
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Bleeding
Comparison of Scoring Systems for Bleeding in Open Cardiac Surgery Patients
Seven different scoring systems used for prediction of perioperative bleeding were compared regarding patients operated for elective open cardiac surgery in the investigator's study.
- Trial name
- NCT03846622
- Testing
- Calculation of scoring systems for bleeding
- Volunteers
- 500 people
- Sponsor
- Kocaeli Derince Education and Research Hospital
Blood Coagulation Disorders, Evidence of Liver Transplantation
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
A point-of-care bleeding management protocol based on global viscoelastic test (thromboelastometry) can change the amount of blood products used during orthotopic liver transplant.
- Conditions
- Blood Coagulation Disorders, Evidence of Liver Transplantation, Liver Cirrhosis
- Trial name
- NCT02239991
- Testing
- Thromboelastometry
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Israelita Albert Einstein
Femoral Neck Fractures, Blood Loss, Surgical
Effect of Regional Anesthesia Techniques on Perioperative Blood Loss in Femoral Neck Fracture Surgery
This retrospective observational study evaluates the effect of different regional anesthesia techniques on perioperative blood loss in patients undergoing femoral neck fracture surgery.
- Conditions
- Femoral Neck Fractures, Blood Loss, Surgical, Postoperative Pain
- Trial name
- NCT07702084
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Anemia, Anemia (Iron-Loading)
Evaluate the Outcomes of Ferric Carboxymaltose in Patients With Perioperative Anemia
The prevalence of preoperative anaemia in patients undergoing major surgery is approximately 30%, and is independently associated with higher mortality, a higher rate of postoperative complications, and a greater probability of…
- Conditions
- Anemia, Anemia (Iron-Loading), Perioperative Bleeding, Infection Prevention
- Trial name
- NCT06948864
- Testing
- Ferric Carboxymaltose (FCM)
- Where
- Spain
- Volunteers
- 152 people
- Sponsor
- Hospital Universitario Infanta Cristina
Cardiac Surgery Subjects
Ionized Calcium and Bleeding in Cardiac Surgery
This retrospective study investigates the association between perioperative plasma ionized calcium concentration and perioperative bleeding in open-heart surgery.
- Trial name
- NCT07634042
- Where
- Finland
- Volunteers
- 4,300 people
- Sponsor
- Helsinki University Central Hospital
Morbid Obesity, Perioperative Hemorrhage
Effect of Tranexamic Acid on Bleeding After Bariatric Surgery
Postoperative bleeding is an important complication of bariatric surgery and may lead to increased morbidity, prolonged hospitalization, and higher healthcare costs.
- Conditions
- Morbid Obesity, Perioperative Hemorrhage, Obesity, Tranexamic Acid
- Trial name
- TXA-BARI (NCT07754396)
- Where
- Greece
- Volunteers
- 140 people
- Sponsor
- G.Gennimatas General Hospital
Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma
Platelet Reactivity in Patients on a Thienopyridine and Awaiting Coronary Artery Bypass Grafting
The primary objective of this exploratory cohort study is to describe levels of platelet reactivity in patients on a thienopyridine awaiting coronary artery bypass grafting (CABG).
- Conditions
- Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma, Post Operative Bleeding
- Trial name
- Serial CABG (NCT01406483)
- Testing
- Platelet reactivity assessment
- Volunteers
- 75 people
- Sponsor
- Medstar Health Research Institute
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Osteoarthritis, Knee
Tranexamic Acid and Drain Use in Knee Arthroplasty
This prospective randomized clinical study is designed to evaluate the effects of intra-articular tranexamic acid (TNA), with or without suction drainage, on perioperative blood management in patients undergoing total knee…
- Trial name
- TNAKnee (NCT07174895)
- Testing
- Intra-articular Tranexamic Acid + Suction Drainage, Intra-articular Tranexamic Acid, Suction Drainage Only
- Where
- Syria
- Volunteers
- 192 people
- Sponsor
- Idlib University
Abnormal Uterine Bleeding
Role of Blood Management in Perioperative Outcomes
There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding.
- Trial name
- NCT04475497
- Testing
- Blood management, Usual care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease, Antiplatelet Therapy
Minimally Invasive Coronary Artery Bypass Supported by Cangrelor
The purpose of this study is to find out whether it is safe and practical to perform MIDCAB surgery (a minimally invasive heart bypass procedure) while patients receive a continuous cangrelor infusion during the operation.
- Conditions
- Coronary Artery Disease, Antiplatelet Therapy, Minimally Invasive Coronary Revascularization Surgery
- Trial name
- MINOTAUR (NCT07514962)
- Testing
- Cangrelor-guided MIDCAB surgery (for the prospective cases), Aspirin MIDCAB surgery (for the historical controls)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Cardiocentro Ticino
Total Hip Arthroplasty
Two Different Administration Methods of Tranexamic Acid on Perioperative Blood Loss During Total Hip Arthroplasty
To compare the two administration methods of tranexamic acid for patients undergoing the first unilateral THA, to explore the effects of tranexamic acid on perioperative blood loss from the aspects of dominant blood loss, hidden…
- Trial name
- NCT03157401
- Testing
- intravenous infusion group, intra-articular injection group, control group
- Volunteers
- 90 people
- Sponsor
- Tengzhou Central People's Hospital