Clinical trials: Periodontal Diseases
Mild Gingival Recession, Periodontal Inflammation
Efficacy and Safety of HA35 Gel for Mild Gingival Recession and Periodontal Inflammation
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with mild gingival recession and chronic…
- Conditions
- Mild Gingival Recession, Periodontal Inflammation, Chronic Gingival Pain, Gingival Redness and Swelling
- Trial name
- HA35-PERI (NCT07577258)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Gingival Topical Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Diabetes Type 2, Periodontal Disease
Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes
The purpose of this clinical study is to evaluate the effect of a behavioral intervention on the number of preventive and treatment dental claims in a population of people with Type 2 Diabetes.
- Conditions
- Diabetes Type 2, Periodontal Disease, Caries
- Trial name
- NCT07619729
- Testing
- Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Colgate Palmolive
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Gingivitis, Gingival Diseases
NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery
The aim of this study is to prove that Novosyn Quick and Monosyn Quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery.
- Conditions
- Gingivitis, Gingival Diseases, Periodontal Diseases
- Trial name
- NOQMOQS (NCT05813236)
- Testing
- Novosyn® in resective periodontal surgery, Monosyn® in resective periodontal surgery
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Aesculap AG
Periodontal Diseases, Periodontitis
An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis
The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal…
- Conditions
- Periodontal Diseases, Periodontitis, Gum Disease
- Trial name
- NCT06656325
- Testing
- Erchonia® FX405
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Erchonia Corporation
Periodontal Disease
Comparison Between Different Interdental Brushes in Adults With Periodontal Disease.
The aim of this exploratory study is to evaluate the efficacy of the tested interdental brush versus comparative interdental brushes in adults with periodontal disease, over a 4-week period.
- Trial name
- NCT07575997
- Testing
- Test interdental brush, Comparative interdental brush
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Periodontal Diseases
Effect of TCI188 Probiotic on Oral Health
To assess the efficacy of TCI188 (Pediococcus acidilactici) Probiotic on Oral Health
- Trial name
- NCT06141083
- Testing
- TCI188 Probiotic
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Periodontal Disease, Oral Deseases
Oral-Spray Bacillus Spore Probiotics for Periodontal Disease Prevention and Supprotive Treatment in the Elderly
Periodontal diseases are strongly associated with dysbiosis of the oral microbiome within the biofilm. Key pathogens, including Streptococcus mutans, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis, contribute…
- Trial name
- NCT07258303
- Testing
- oral-spray 0.9% NaCl physiological saline solution, LiveSpo Smile CARE
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Periodontal Disease
Assessment of the Efficacy and Safety of OROXID® Oral Solution in Patients With Periodontitis
Periodontitis is a chronic, irreversible inflammatory disease affecting the supporting structures of the teeth. It is most commonly caused by bacteria in dental plaque, also known as biofilm.
- Trial name
- OroxParodont (NCT07257887)
- Testing
- OROXID® forte oral solution, OROXID® sensitive oral solution, Standard of Care
- Where
- 2 sites in Slovenia
- Volunteers
- 90 people
- Sponsor
- ENIKAM d.o.o.
Periodontal Disease
Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age
The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study.
- Trial name
- NCT06582056
- Testing
- Investigational Procedure
- Where
- 4 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Gingivitis, Gingivitis and Periodontal Diseases
Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and Gingivitis
This is a Phase III, one-center, parallel group, double blind, clinical study to evaluate the effect of a toothpaste containing 0.3% chlorhexidine in subjects with established dental plaque and gingivitis.
- Conditions
- Gingivitis, Gingivitis and Periodontal Diseases, Gingival Disease, Dental Plaque
- Trial name
- CHX TP (NCT06732466)
- Testing
- Chlorhexidine toothpaste, Toothbrush
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Colgate Palmolive
Gingival Bleeding, Plaque Induced Gingival Disease
Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis.
This is a Phase III, randomized, one-center, parallel group, double blinded, clinical study to evaluate the efficacy of an alcohol-free mouthwash containing CPC+Zn as compared to dental flossing and to rising with an essential…
- Conditions
- Gingival Bleeding, Plaque Induced Gingival Disease, Gingival Diseases, Gingivitis and Periodontal Diseases
- Trial name
- PGMWII (NCT06598072)
- Testing
- Mouthwash CPC+Zn+F, Essential oils mouthwash, Dental floss
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Colgate Palmolive
Gingival Bleeding, Plaque Induced Gingival Disease
Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction
Clinical study evaluating the effectiveness of an alcohol-free mouthwash containing CPC+Zn compared to dental flossing and an essential oils-containing alcohol mouthwash in reducing dental plaque and gingivitis.
- Conditions
- Gingival Bleeding, Plaque Induced Gingival Disease, Gingivitis and Periodontal Diseases
- Trial name
- PGMWI (NCT06607263)
- Testing
- Mouthwash CPC+Zn+F, Essential oils mouthrinse, Dental floss
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Colgate Palmolive
Periodontal Diseases, Periodontitis
Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis
This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long…
- Conditions
- Periodontal Diseases, Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05425784
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 3 sites in Finland
- Volunteers
- 41 people
- Sponsor
- Koite Health Oy
Parodontitis
Evaluation of the Efficacy of STERIFY GEL in the Treatment of Periodontitis Following Scaling and Root Planing
The purpose of this clinical study is to evaluate the safety and efficacy of treating periodontal disease with the STERIFY GEL medical device in combination with SRP procedure, in terms of periodontal pocket healing.
- Trial name
- SFYCT (NCT05975177)
- Testing
- Sterify Gel, Scaling and root planing
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Sterify S.r.l.
Periodontitis, Periodontal Pocket
Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Diseases, Periodontal Inflammation
- Trial name
- Chitosangel (NCT05773911)
- Testing
- 4% chitosan gel (pH 3.48)., Reciprocal Chitosan brush
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caspar Wohlfahrt
Periodontal Diseases
Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis
A comparison of laser (REPaiR) compared with minimally invasive surgical therapy for moderate to severe periodontal disease.
- Trial name
- NCT04169139
- Testing
- MIST (minimally invasive surgical therapy)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McGuire Institute
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Peri-Implantitis
The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis
The objective of the study is to assess the efficacy and safety of PerioChip® (Chlorhexidine gluconate chip) in the treatment of patients with Peri-implantitis.
- Trial name
- NCT02080403
- Testing
- 2.5 mg Chlorhexidine gluconate chip
- Where
- 10 sites in United States, Germany and 2 more
- Volunteers
- 290 people
- Sponsor
- Dexcel Pharma Technologies Ltd.