Clinical trials: Periodontal Attachment Loss
Periodontitis, Alveolar Bone Loss
Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)
This study aims to verify the effectiveness of Trafermin (recombinant human basic fibroblast growth factor) in stimulating regeneration of periodontal tissue lost by periodontitis and to evaluate the safety of such stimulation.
- Conditions
- Periodontitis, Alveolar Bone Loss, Periodontal Attachment Loss
- Trial name
- NCT00734708
- Testing
- Trafermin (genetical recombination)
- Where
- 21 sites in Japan
- Volunteers
- 328 people
- Sponsor
- Kaken Pharmaceutical
Pocket, Periodontal, Periodontal Inflammation
Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical Study
Routine non surgical periodontal thearpy often fails to achieve complete elimination of pathogenic microorganism. This could be attiributable to deep periodontal pockets, root concavities, furcation involvement etc.
- Conditions
- Pocket, Periodontal, Periodontal Inflammation, Periodontal Attachment Loss, Periodontitis
- Trial name
- NCT06404190
- Testing
- Diode laser and 3% hydrogen peroxide
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Diseases, Periodontal Pocket
Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.
The aim of the present study is to clinically and radiographically compare the effectivness of Scaling and Root Plannig (SRP) in association with lipo-curcumin gel (LC) respect SRP+ lipo-gel (L), SRP+ discharged (D) gel and SRP…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT06624241
- Testing
- Lipo-Curcumin gel + SRP, Lipo gel + SRP, Discharged Gel + SRP
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontitis, Periodontal Inflammation
PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy
Periodontitis is characterized by a chronic, multifactorial inflammatory process driven by dysbiotic plaque biofilms. It is recognized as the most common chronic inflammatory non-communicable disease in humans.
- Conditions
- Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- PRFSTEP2 (NCT07013682)
- Testing
- PRF as adjunct to non-surgical mechanical debridement, Control, non-surgical mechanical debridement alone
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Gingival Recession, Gingival Diseases
Influence of Anatomical Factors Upon Root Coverage
Introduction: Gingival recession is a lesion characterized by the loss of attachment of root surface of the tooth, resulting in an apical migration of the gingival margin that occasionally generates aesthetic problems…
- Conditions
- Gingival Recession, Gingival Diseases, Periodontal Attachment Loss
- Trial name
- NCT04813302
- Testing
- Coronally advanced flap and connective tissue graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Periodontal Bone Loss
Effect of Enamel Matrix Proteins on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
The purpose of the study is to determine the effect of enamel matrix protein derivative on an inflamed, periodontal-involved tooth.
- Trial name
- NCT02972788
- Testing
- Enamel Matrix Proteins Derivative, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
Gingival Recession, Localized, Sensitivity, Tooth
Two Different Graft Harvesting Techniques Applied in Localized Gingival Recessions
The primary purpose of this study is to compare the root coverage rate of the gingival unit-shaped connective tissue graft, obtained by intraoral de-epithelization, with the traditional de-epithelialized free gingival graft in…
- Conditions
- Gingival Recession, Localized, Sensitivity, Tooth, Attachment Loss, Periodontal
- Trial name
- NCT05923294
- Testing
- Coronally advanced flap with connective tissue graft
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Periodontitis Stage I, Periodontal Diseases
Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis
this study addresses the effect of the vitamin B3 and vitamin B9 on the periodontal healing at the sites of periodontal destruction due to periodontitis and evaluate its added effect to the conventional non-surgical periodontal…
- Conditions
- Periodontitis Stage I, Periodontal Diseases, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- NCT05435378
- Testing
- Vitamin B3 100 MG Oral Tablet, vitamin B9, full mouth non surgical periodontal treatment
- Volunteers
- 30 people
- Sponsor
- Cairo University
Periodontitis, Periodontal Diseases
The Impact of Obesity on Nonsurgical Periodontal Therapy
The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Obesity
- Trial name
- NCT01405365
- Testing
- Metronidazole, Scaling and root planning
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Periodontitis Complex
Periodontal Regeneration Versus Tooth Extraction and Replacement Denture in Teeth With Periodontal Hopeless Prognosis
Periodontal regeneration can change tooth prognosis and represents an alternative to extraction in teeth compromised by severe intrabony defects.
- Trial name
- NCT04227964
- Testing
- Enamel matrix derivative, bone replacement graft, barrier membrane, Tooth extraction and replacement
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The European Research Group on Periodontology (ERGOPerio)
Periodontitis, Gingivitis and Periodontal Diseases
Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical Therapy
# Brief Summary (Word count: 198) This combined observational and interventional study investigates salivary amino acid profiles and their connections to periodontal conditions, as well as how these substances change after…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Periodontal Debridement, Periodontal Attachment Loss
- Trial name
- FAA-CP-SRP (NCT07669233)
- Testing
- Non-surgical periodontal therapy
- Where
- China
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Zhang, Yuwei
Periodontitis, Periodontal Pocket
Modified Widman Flap vs Fibre Retention Osseous Resective Surgery
The treatment of periodontitis should be carried out in an incremental manner, first by achieving adequate patient's oral hygiene practices and risk factor control during the first step of therapy and then, during the second step…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT06123000
- Testing
- Modified Widman Flap (MWF), Fiber Retention Osseous Resective Surgery (FibReORS)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Florence
Periodontal Diseases, Periodontal Inflammation
Therapeutic Application of Coconut Oil in Oral Health
The scientific literature has verified that coconut oil has properties that open perspectives for its application in order to maintain oral health and, in particular, for the treatment of different oral pathologies.
- Conditions
- Periodontal Diseases, Periodontal Inflammation, Periodontal Attachment Loss, Periodontitis
- Trial name
- NCT06049589
- Testing
- Coconut Oil, Chlorhexidine mouthwash, Water mouthwash
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinica Pardinas
Periodontitis, Type 2 Diabetes Mellitus
Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic
The purpose of the study was to monitor the activity of periodontal disease and suggest potential biomarkers related to active periodontal disease in patients with chronic periodontitis (PD) associated or not with type 2 diabetes…
- Trial name
- NCT02220751
- Testing
- non-surgical periodontal therapy + systemic doxycycline, Non-surgical periodontal therapy
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontal Attachment Loss, Periodontal Diseases
Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain
The primary objective of this study is to demonstrate that in supra-alveolar-type defects (i.e., defects displaying a predominately horizontal pattern of bone loss), periodontal surgery with the additional use of Straumann®…
- Trial name
- NCT01614925
- Testing
- Emdogain, Periodontal surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Institut Straumann AG
Periodontal Attachment Loss, Periodontal Pocket
Dietary Intakes and Periodontal Health: A Follow-Up Study
A previous study, on which this study is based, found that a diet higher in fruits and vegetables, beta-carotene, vitamin C, alpha-tocopherol, and fish oils (specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid…
- Trial name
- NCT03073174
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Brock University
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
Periodontitis, Chronic Periodontitis
Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy
This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy.
- Trial name
- VECTOR-RCT (NCT07452640)
- Testing
- Vector® Ultrasonic System, Mini-Five Curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University
Periodontitis, Periodontal Diseases
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT07536204
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile