Clinical trials: Periapical Diseases
Endodontic Inflammation
Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment
The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth.
- Trial name
- NCT07779148
- Testing
- Xp Finisher R file
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Minia University
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing
The aim of this study is to compare the effect of passive ultrasonic irrigation versus needle irrigation on post-operative pain and healing in patients with permanent posterior teeth with apical periodontitis treated in a single…
- Trial name
- NCT02913937
- Testing
- Passive ultrasonic irrigation, Endodontic needle
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pulp Necrosis, Apical Periodontitis
Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic…
- Trial name
- NCT07897591
- Testing
- Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Apical Periodontitis
Effect of Coronal Extent of Obturation on Endo-perio Lesions
Increased incidence of apical periodontitis was reported where root filling was found coronal to the marginal bone due to communication between pulp and periodontal space.
- Trial name
- NCT03171376
- Testing
- Root canal treatment and coronal restoration
- Volunteers
- 60 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic Infection, Periapical Diseases
The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery.
Background This randomized clinical trial evaluated the effect of two different hemostatic materials for endodontic microsurgery on bleeding control, postoperative pain and patients' quality of life.
- Trial name
- NCT07311291
- Testing
- Hemostatic Agent 1: Surgical glue (IfaBond, Dipromed, Italy), Hemostatic Agent 2: Ferric sulfate
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Dental Pulp Necrosis, Dental Pulp Disease
Digitized Assessment for the Survival of Mature Anterior Teeth With Periapical Lesion After One Step Regenerative Approach Using Different Asepsis Maneuvers
Trial is designed to allow revascularization and tissue engineering in necrotic teeth with peripical lesion in a single visit approach.
- Conditions
- Dental Pulp Necrosis, Dental Pulp Disease, Dental Pulp; Degeneration
- Trial name
- RCT (NCT03652129)
- Testing
- Disinfection
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intracanal Dressing, Apical Periodontitis
Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: Intensity of postoperative pain levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers
- Trial name
- NCT07101029
- Testing
- Bio-C Temp Intracanal Medication, Calcium Hydroxide Intracanal medication
- Volunteers
- 30 people
- Sponsor
- Cairo University
Necrotic Pulp
Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments
The aim of this study is to evaluate the post treatment pain after instrumentation of root canals with a single file reciprocating (Wave-One Ni Ti file, DENTSPLY Maillefer) or rotary(One Shape, Micro Mega, France) file system in…
- Trial name
- NCT03301259
- Testing
- One-shape rotationary system
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Oxidative Stress
Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Periodontitis
This clinical study aims to investigate the oxidative stress-related effects of ozone irrigation in patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07171762
- Testing
- Ozonytron XP, Physiological saline solution (0.9% NaCl)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- KEZBAN MELTEM ÇOLAK
Apical Periodontitis
Retreatment and Diabetes
ABSTRACT This prospective, controlled, single-center clinical study aims to compare postoperative pain levels and analgesic consumption after nonsurgical endodontic retreatment in individuals with diabetes mellitus and…
- Trial name
- NCT07679880
- Testing
- root canal retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Periapical Periodontitis
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
A total of 185 subjects were divided into three categories: AP group (n=85), CP group (n=50) and healthy control group (n=50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI) based on the…
- Trial name
- NCT06023901
- Testing
- Apical periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Apical Periodontitis
Effectiveness of Laser-activated Photoacoustic Flow in One-visit Revision of Teeth With Apical Periodontitis
The main objective of the clinical randomized study is to examine the effectiveness laser-activated irrigation (LAI) on the removal of intracanal microorganisms and the healing of an inflammatory periapical lesion of a tooth…
- Trial name
- NCT07387809
- Testing
- Laser activated irrigation, Sound-activated irrigation
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University of Zagreb
Pulpitis, Periapical Lesions
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida…
- Conditions
- Pulpitis, Periapical Lesions, Periapical Periodontitis, Periapical Pathology
- Trial name
- NCT07019298
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Endodontic Disease, Endodontic Re-treatment Failure
Guided Versus Conventional Periapical Endodontic Surgery
This study is to compare the clinical and radiographic outcomes after guided periapical endodontic surgery versus conventional endodontic surgery.
- Trial name
- NCT04133181
- Testing
- 3D guide, Mock guide
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
In Vivo Assessment of Endodontics Procedures
In view of the wide variety of mechanized endodontic instrumentation systems, the ideal would be that the choose of this system based on the anatomical characteristics of the canal and the biological precepts.
- Trial name
- NCT03243357
- Testing
- TF Adaptive (First Apical Binding File), TF Adaptive (Control)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Uberlandia