Clinical trials: Perianal Fistula
Crohn Disease, Perianal Fistula
Risankizumab for Refractory Perianal Fistulizing Crohn's Disease
Crohn's disease is an inflammatory bowel disease characterized by relapses and remissions, causing lesions throughout the digestive tract and accompanied by diarrhea, abdominal pain, and nutritional disorders.
- Conditions
- Crohn Disease, Perianal Fistula, Perianal Fistula Due to Crohn's Disease, Perianal Crohn's Disease
- Trial name
- RIS-PERIANAL (NCT07872449)
- Testing
- Risankizumab
- Where
- 4 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Yuki Horio
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Crohn Disease, Perianal Fistulas
Adipose Tissue Injection in Perianal Fistulas in Crohn´s Disease
This randomized and placebo controlled study investigates the efficacy of injections with freshly harvested autologous adipose tissue in CD patients with complex perianal fistulas refractory to standard surgical and/or medical…
- Conditions
- Crohn Disease, Perianal Fistulas, Cell- and Tissue-Based Therapy, Treatment
- Trial name
- NCT03904212
- Testing
- Adipose tissue injection, saline
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Crohn's Disease With Perianal Fistulas
Clinical Study on the Integration of Traditional Chinese Medicine Virtual Hanging Therapy With Mesenchymal Stem Cells for the Treatment of Crohn's Disease-Associated Anal Fistula.
To evaluate the efficacy and safety of TCM virtual hanging therapy combined with mesenchymal stem cellsin the treatment of CD anal fistula.
- Trial name
- VH-MSC-CDAF (NCT07113795)
- Testing
- TCM dummy therapy combined with mesenchymal stem cell injection therapy, Dummy Line Therapy Group, MSC Group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Anorectal Center of Nanjing Hospital of Traditional Chinese Medicine
Cryptoglandular Perianal Fistula
Loose Seton Prior to Surgery for Single-tract Cryptoglandular Fistula vs no Seton
Cryptoglandular anal fistulas can cause pain, discharge, recurrent infection, and a prolonged treatment course. In current practice, patients with a single-tract mid-high or high cryptoglandular anal fistula often first undergo…
- Trial name
- SETON (NCT07807319)
- Testing
- No seton placement prior to surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Proctos Kliniek
Wound Healing, Anal Fistula
Platelet- Rich Plasma Injection
This randomized controlled study aims to investigate the effect of injection of platelet rich plasma on the postoperative outcome of perianal wound after anal fistula surgery in terms of healing time, reduction in wound size…
- Trial name
- prp (NCT06887166)
- Testing
- Platelet Rich Plasma
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Crohn Disease, Perianal Fistula
Micro-fragmented Adipose Tissue and Complex Crohns' Anal Fistulas
The study aims to evaluate safety, feasibility and effectiveness of local injections of autologous and micro-fragmented adipose tissue obtained with the Lipogems® system in patients with refractory complex fistulizing perianal…
- Trial name
- NCT03555773
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Perianal Fistula, Fistula-in-Ano
Open Fistulectomy vs. Laser Closure for Low Perianal Fistula
Perianal fistula is an abnormal tunnel connecting the anal canal to the perianal skin, frequently causing chronic pain, discharge, and impaired quality of life.
- Conditions
- Perianal Fistula, Fistula-in-Ano, Low Perianal Fistula
- Trial name
- NCT07797842
- Testing
- Fistula-tract Laser Closure (FiLaC), Open Fistulectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Crohn's Disease, Perianal Fistula
MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease
This Phase 4, single-arm, open-label study will evaluate the effectiveness and safety of mirikizumab combined with surgical curettage and closure in adults with active perianal fistulizing Crohn's disease.
- Trial name
- MIRICURE (NCT07782021)
- Testing
- Mirikizumab, Fistula Tract Curettage and Closure
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Complex Perianal Fistulas
The Purpose of This Study is to Evaluate the Safety and Efficacy of Human TH-SC01 Cell Injection in the Treatment of Complex Perianal Fistula
The purpose of this study is to evaluate the safety and efficacy of human TH-SC01 cell injection for the treatment of complex perianal fistulas
- Trial name
- NCT05677672
- Testing
- Human TH-SC01 Cell Injection, Saline solution
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Perianal Fistula
Stem Cell Therapy: a Compassionate Use Program in Perianal Fistula
This observational study aims at assessing the safety and efficacy profiles of mesenchymal stem cell, in different formats (SVF, autologous, allogenic), to treat complex perianal fistula according to the Spanish national…
- Trial name
- RESCeCUF (NCT03726255)
- Testing
- Mesenchymal Stem Cell injection
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Anal Fistula
Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells
Efficacy of treatment of perianal fistula with mesenchymal stem cells and surgery
- Trial name
- FISPAC (NCT01803347)
- Testing
- ◦Drug: ASCs. + fibrin glue, fibrin glue
- Where
- 5 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Perianal Fistulas
Efficacy and Safety Study of a Medical Device (KULIST)to Treat Perianal Fistulas
The aim of this study is to evaluate the effects of rectally administered activated carbon (medical device KULIST) in chronic, uncomplicated, perianal fistulas.
- Trial name
- NCT01462747
- Testing
- KULIST
- Where
- 2 sites in Sweden
- Volunteers
- 28 people
- Sponsor
- Nordic Drugs AB
Perianal Fistula in Patients With Crohn's Disease
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's Patients
Study aim: Safety of Human Placenta Mesenchymal Stem Cells Derived Exosomes for treatment of perianal fistula in patients with Crohn's disease 2.
- Trial name
- NCT05499156
- Testing
- placenal MSC derived exosomes
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Anal Fistula, Rectal Fistula
Surgical Treatment of High Perianal Fistulas
Perianal fistula is a chronic phase of anorectal infection that occurs predominantly in the third and fourth decade of life. According to Parks classification fistulas have been divided into intersphincteric, transsphincteric…
- Trial name
- LIFTRAF (NCT01997645)
- Testing
- LIFT, RAF
- Where
- 3 sites in Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Hradec Kralove
Crohn Disease, Complex Perianal Fistula
A Study to Check How Often People Treated With Darvadstrocel for Crohn's Disease Are Diagnosed With Cancer
The main aim is to learn about the risk of cancer after treatment with darvadstrocel compared to other standards of care in people with Crohn's Disease (CD).
- Trial name
- NCT04971525
- Where
- 4 sites in France, Germany and 2 more
- Sponsor
- Takeda
Hemorrhoids, Fissure in Ano
Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
The primary aim is to test the magnitude and duration of analgesia provided by single dose multi-drug analgesia administered for perianal block, and compare with standard solution (Marcaine \& Lidocaine in 1:1 mixture - Total 60…
- Conditions
- Hemorrhoids, Fissure in Ano, Fistula;Rectal
- Trial name
- NCT03105674
- Testing
- Multi-drug local anesthetics (Combination), Standard local anesthetics (Combination)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Crohn's Disease, Complex Perianal Fistula
Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula
The main aim is to follow-up on long term side effect and symptom improvement of Darvadstrocel in the treatment of complex perianal fistula in adults. Participants will not receive any drug in this study.
- Trial name
- NCT04075825
- Testing
- Darvadstrocel
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 150 people
- Sponsor
- Takeda
Anal Fistula, Crohn Disease
Stem Cells Treatment of Complex Crohn's Anal Fistula
A pilot study to investigate the safety and feasibility of stem cells treatment of complex anal fistula in patients with Crohn's disease.
- Trial name
- fistula (NCT03466515)
- Testing
- stem cells injection
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Southern Denmark
Inflammatory Bowel Disease, Perianal Fistula
Perianal Fistula (PAF) Validation and Burden of Illness Study
The purpose of this study is to gain a better understanding of the disease burden and unmet need of perianal fistulas within Crohn's disease (CD) in Ontario.
- Conditions
- Inflammatory Bowel Disease, Perianal Fistula, Crohns Disease
- Trial name
- NCT03981939
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 3,032 people
- Sponsor
- Takeda