Clinical trials: Peri-menopausal Women
Menopause, Perimenopausal Disorder
Effectiveness of Assessment and Educational Intervention on Motor Control of the Pelvic Floor Muscle in Women
The goal of the present study is to evaluate the short and long term effectiveness of a tailored assessment and educational intervention on motor control of the pelvic floor muscle in menopausal and non-menopausal women.
- Trial name
- MENO_edu (NCT03220672)
- Testing
- Tailored assessment and educational
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Breast Cancer
Pilot Study of the Effect of Duavee® on Benign Breast Tissue Proliferation
The purpose of this study is to learn whether daily use of Duavee® is accepted and tolerated by peri- and post-menopausal women at moderate risk for development of breast cancer.
- Trial name
- NCT02729701
- Testing
- Duavee
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Kansas Medical Center
Menopause
Menopausal Symptoms Probiotic Study
In this study, we want to investigate if the active product consisting of a probiotic blend can potentiate the recirculation of active oestrogens into the bloodstream and help to mitigate menopause symptoms, which are closely…
- Trial name
- NCT06446869
- Testing
- Gyntima Menopause
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Community Pharmacology Services Ltd
Peri-menopausal Women
Qualia Perimenopause Efficacy and Tolerability Study: An Open-label 3-Arm Trial
This is an open-label, 3-arm clinical trial evaluating the short-term efficacy and tolerability of Qualia Perimenopause-a multi-ingredient dietary supplement formulated to support perimenopausal symptoms-in healthy women aged…
- Trial name
- NCT07361757
- Testing
- Qualia Perimenopause Formula A, Qualia Perimenopause Formula B, Qualia Perimenopause Formula C
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Qualia Life Sciences
to Assess Changes in Body Composition After Dietary Supplementation With Sinetrol
A Randomized, Double-blind, Placebo-controlled, Parallel Study to Assess the Effect of Sinetrol on Body Composition &Metabolic Health in Peri-menopausal/Early Menopausal Women
The menopausal transition is associated with significant hormonal and metabolic changes, primarily driven by a decline in estrogen levels.
- Trial name
- MENOFIT (NCT07782853)
- Testing
- dietary supplementation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DR Healthcare - biotexia
Urinary Tract Infections
The Urinary Microbiome and Its Relationship to the Urinary and Serum Metabolome in Healthy Peri- and Postmenopausal Women
The presented project aims to characterize the microbiome of healthy peri- and postmenopausal women and its correlation with the metabolome of urine and serum.
- Trial name
- NCT06573827
- Testing
- Blood and urine sample evaluation
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Ostrava
Post-Menopausal Osteoporosis
Intra-venous Zoledronic Acid Once Yearly
The study will assess the real life effectiveness of zoledronic acid in the management of patients with osteoporosis over 4 years of treatment.
- Trial name
- IVORY (NCT00984893)
- Testing
- zoledronic acid, Any oral bisphosphonates marketed in Canada
- Where
- 3 sites in Canada
- Volunteers
- 1,551 people
- Sponsor
- Novartis Pharmaceuticals
Infertility, Female, Anovulatory Infertility
Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.
- Conditions
- Infertility, Female, Anovulatory Infertility, Menopause, Amenorrhea
- Trial name
- PRP (NCT03916978)
- Testing
- Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Hair Thinning
Efficacy and Safety of a Nutraceutical Supplement With Standardized Botanicals in Peri-menopausal and Menopausal Women With Thinning Hair
NUTRAFOL® Women's Balance supplement is a novel nutraceutical supplement, scientifically formulated to specifically target the multiple underlying causes of hair loss and thinning in women.
- Trial name
- NCT04048031
- Testing
- Nutrafol Supplement Capsules
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ablon Skin Institute Research Center
Menopause
Estrogen Diastolic Heart Failure
Peri-menopausal women will be randomized to hormone replacement therapy or placebo for 12 weeks to determine if markers of systolic and diastolic function change by echocardiography as well as laboratory markers of heart failure…
- Trial name
- NCT02693002
- Testing
- Estradiol/Norethindrone acetate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Gretchen Wells
Osteoporosis, Osteopenia
Melatonin Osteoporosis Prevention Study
Osteoporosis is one of the most common skeletal disorders. Today in the United States, 10 million individuals have osteoporosis and 34 million more have low bone mass or osteopenia, which places them at an increased risk of some…
- Trial name
- MOPS (NCT01152580)
- Testing
- melatonin, sugar pill
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Nonalcoholic Steatohepatitis, Liver Fibroses
Liver Fibrosis in Peri-menopausal Women
This is a prospective observational study in a single medical center. The aim is to evaluate the status of fibrosis and steatosis of liver parenchyma in peri-menopausal women using noninvasive methods of vibration-controlled…
- Conditions
- Nonalcoholic Steatohepatitis, Liver Fibroses, Menopause
- Trial name
- NCT03602573
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Menopausal Symptoms
A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women
The purpose of this study is to assess the effectiveness of an herbal combination product called Nu Femme, on menopausal symptoms in peri-menopausal women.
- Trial name
- 14NMHB (NCT02269891)
- Testing
- Nu Femme
- Where
- 4 sites in Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Perimenopause, Vasodilation
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women
The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women.
- Conditions
- Perimenopause, Vasodilation, Estrogen
- Trial name
- NCT04255160
- Testing
- Estradiol (mylan or vivelle dot patch)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Menopause, Hot Flashes
Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms (VMS) in Peri- and Postmenopausal Women
The broad goal of this study is to obtain pilot data to determine the tolerability and preliminary efficacy of the non-hormonal agent gabapentin for insomnia symptoms and nighttime vasomotor Symptoms (VMS) when open-label…
- Conditions
- Menopause, Hot Flashes, Vasomotor Disturbance
- Trial name
- NCT02040532
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Late-perimenopause, Menopause
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
The goal of this randomised controlled trial is to investigate whether Time-Restricted Eating (TRE) combined with a Low Glycaemic Index Mediterranean Diet can improve cognitive function, metabolic health, and biological ageing in…
- Conditions
- Late-perimenopause, Menopause, Perimenopause
- Trial name
- NutriAge (NCT07378787)
- Testing
- Time-Restricted Low-Glycaemic Index Diet
- Where
- 2 sites in Croatia, Cyprus
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Menopausal Women, Insomnia
Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms
The goal of this clinical trial is to learn how three current insomnia therapies (trazodone, daridorexant, cognitive behavioral therapy for insomnia) compare with each other in peri- and post-menopausal women.
- Trial name
- CELESTE (NCT07136415)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-i), Trazodone, Daridorexant
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Obesity
SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight
This study is open to women up to 65 years of age who are living with overweight or obesity and are going through or have finished menopause.
- Trial name
- NCT07850050
- Testing
- Survodutide
- Where
- 13 sites in United States
- Volunteers
- 600 people
- Sponsor
- Boehringer Ingelheim
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Mammography, Estrogen
Zoladex Plus Tamoxifen in Breast Cancer
The purpose of this study is to compare Zoladex plus tamoxifen with tamoxifen alone as adjuvant hormonal therapy in pre- or perimenopausal women with early-stage breast cancer in terms of breast density, estrogen levels…
- Conditions
- Mammography, Estrogen, Lipemia, Endometrium
- Trial name
- NCT00827307
- Testing
- tamoxifen, Goserelin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital