Clinical trials: Pelvic Floor Prolapse
Quality of Life, Pelvic Floor Distress and Impact Scores
Physical Therapy on Quality of Life and Function Following Vaginal Surgery Reconstructive Surgery
i) The primary objective of this study is to determine if physical therapy improves postoperative quality of life in participants following vaginal reconstructive surgery for pelvic organ prolapse and urinary incontinence.
- Conditions
- Quality of Life, Pelvic Floor Distress and Impact Scores, Sexual Function Scores
- Trial name
- PT and QOL (NCT01403701)
- Testing
- Physical therapy
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Urethra Issue, Pelvic Organ Prolapse
Lessons on Urethral Lidocaine in Urodynamics
This trial will assess whether use of intraurethral 2% lidocaine jelly meaningfully impacts sensation during filling (i.e., a change of more than 25% of first sensation, first desire to void, strong desire to void, or maximum…
- Conditions
- Urethra Issue, Pelvic Organ Prolapse, Urinary Incontinence, Vaginal Vault Prolapse
- Trial name
- LULU (NCT04038099)
- Testing
- Water-Based Vaginal Lubricant, lidocaine topical
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Texas Southwestern Medical Center
Pelvic Organ Prolapse, Pelvic Floor Prolapse
Laparoscopic Lateral Suspension With Mesh & Sacrocervicopexy for the Treatment of Uterine Prolapse
This study is aimed to compare the efficiency of two uterus-preserving laparoscopic methods to treat uterine prolapse in a randomized controlled trial.
- Trial name
- NCT03421457
- Testing
- Uterus-preserving laparoscopic lateral suspension with mesh, Uterus-preserving laparoscopic sacrocervicopexy with mesh
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Rectal Prolapse, Pelvic Organ Prolapse
Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction
The purpose of this randomized double blind controlled study is to assess the value of robotics for the treatment of complex pelvic floor dysfunction.
- Trial name
- NCT01346436
- Testing
- Minimally invasive rectopexy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Nicolas C. Buchs
Pelvic Organ Prolapse
Robotic Assisted Sacral Colpopexy : A Prospective Study Assessing Outcomes With Learning Curves
The investigators scientific aims are to determine the benefits associated with the use of robotic assisted laparoscopic sacrocolpopexy surgery on women with prolapse, to define how the benefits impact the patient, physician and…
- Trial name
- NCT01535833
- Testing
- Device- Robotic sacral colpopexy
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Pelvic Organ Prolapse
Physical Therapy on Pelvic Organ Prolapse
OBJECTIVE: To evaluate the effectiveness of an individualized pelvic floor physiotherapy programme combined with lifestyle education compared with lifestyle education alone in women with stage I or II pelvic organ prolapse (POP).
- Trial name
- PT-POP (NCT03244397)
- Testing
- Physical therapy + educational strategy, Educational strategy
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- University of Alcala
Pelvic Floor Prolapse
Prolift Versus IVS for Pelvic Floor Prolapse
Women who underwent mesh or sling procedures to correct pelvic organ prolapse will be enrolled. Their data will be collected from the files.
- Trial name
- NCT01383291
- Where
- 2 sites in Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Pelvic Organ Prolapse, Menopause
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall.
- Trial name
- PET (NCT01778985)
- Testing
- Premarin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sacrospinofixation, Apical Prolapse
Concordance of Pelvic Organ Mobility Measurements Between the Finite Element Model and the Dynamic Pelvic Floor MRI in Patients Undergoing a Sacrospinofixation Surgery
The primary objective of this study is to demonstrate the feasibility of using a Finite Element model of pelvic organs by evaluating the concordance of pelvic organ mobility measurements performed by this mechanical model…
- Trial name
- BiomécaRichter (NCT04551859)
- Testing
- Dynamic Pelvic Floor MRI
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pelvic Organ Prolapse (POP), Cystocele
Poly-L-Lactic Acid for Vulvovaginal Tissue Regeneration
Pelvic organ prolapse (POP) is a condition characterized by descent of vaginal walls, uterus and cervix, or the perineum and causes a sensation of vaginal bulge and pelvic pressure.
- Conditions
- Pelvic Organ Prolapse (POP), Cystocele, Pelvic Floor Disorder
- Trial name
- NCT07544667
- Testing
- Poly-L-Lactic Acid (Sculptra) injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cassandra Kisby
Pelvic Organ Prolapse, Urinary Incontinence
Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures
This is a randomized controlled trial to determine if there is a difference between chlorhexidine gluconate and povidone iodine vaginal preparations for urogynecological surgery post operative infections.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pelvic Floor Disorders, Gynecologic Disease
- Trial name
- CLNUP (NCT04048356)
- Testing
- Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pelvic Floor Disorders, Urinary Incontinence (UI)
Motivational Interviewing in Women's Pelvic Wellness Education
This pilot study will assess the feasibility and acceptability of an educational workshop on pelvic floor disorders and its potential impact on decisional conflict.
- Conditions
- Pelvic Floor Disorders, Urinary Incontinence (UI), Pelvic Prolapse Conditions
- Trial name
- NCT02758561
- Testing
- Workshop
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Pelvic Organ Prolapse
Pelvic Floor Study: Biomechanical Properties of the Female Pelvic Floor
Pelvic floor dysfunction in the form of pelvic organ prolapse or urinary and fecal incontinence is a sequela for some women who experience injuries during birth. It affects adult women of all ages.
- Trial name
- NCT01042470
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- David Scheiner
Pelvic Floor Disorders
Pelvic Floor Function Evaluation of Singleton Primiparae After Vaginal Delivery and Cesarean Section
Objective of this longitudinal observational cohort study was to analyze incidence of pelvic floor dysfunction (PFD) symptoms, including pelvic organ prolapse (POP), urinary incontinence (UI), and fecal incontinence (FI), seven…
- Trial name
- NCT02661867
- Testing
- delivery
- Volunteers
- 865 people
- Sponsor
- Brno University Hospital
Vaginal Vault Prolapse, Pelvic Floor Prolapse
Vaginal Vault Prolapse Surgical Treatment
Since apical support is the mainstay of vaginal cuff restoration, sacrocolpopexy is still accepted as the gold standard technique in vaginal vault prolapse (VVP).
- Trial name
- VVPST (NCT06792331)
- Testing
- vNOTES high uterosacral ligament suspension, Laparoscopic lateral suspension
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Pelvic Organ Prolapse Recurrence
The Efficacy of Laparoscopic Sacrocolpopexy in the Treatment of Pelvic Organ Prolapse in Women With or Without Avulsion of the Levator Ani Muscle
Based on a prospective study, to evaluate how pre-operative pelvic floor status - the presence of injury to the musculus levator ani - may influence the results of laparoscopic sacrocolpopexy.
- Trial name
- NCT03049020
- Testing
- laparoscopic sacrocolpopexy
- Where
- 2 sites in Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Prolapse
Use of Non-ablative Vaginal Erbium YAG Laser for the Treatment of Prolapse
This is a single center, investigator initiated study, sponsored by the UZ Leuven, Leuven, Belgium; comparing laser treatment to pelvic floor exercises (PFE).
- Trial name
- VELPOP (NCT04523298)
- Testing
- Non-ablative vaginal Erbium YAG laser treatment, Pelvic floor exercises (PFE)
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Uterine Prolapse, Stage III
GYNECARE PROSIMA* Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Uterine Prolapse Stage III
Pelvic Organ prolapse (a feeling of bulge in the vagina) may cause some distressing symptoms such as loss of control of the bowel or bladder, and may also cause problems with patient's sex life.
- Trial name
- NCT01396109
- Testing
- Procedure: TVH and GYNECARE PROSIMA* Pelvic Floor Repair System, Procedure: TVH and Modified Pelvic Floor Reconstruction Surgery with mesh
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Uterine Prolapse
Combined Effects of Pelvic Floor Retraining and Hypopressive Exercises in Uterine Prolapse Outcomes
One common pelvic floor condition, particularly in postpartum or later life, is uterine prolapse. It is caused by weak pelvic floor muscles and connective tissues and often presents with pain, urinary incontinence, and reduced…
- Trial name
- NCT07642180
- Testing
- Functional Movement Retraining + Hypopressive Exercises, Pelvic Floor Functional Movement Retraining
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University