Clinical trials: Pelvic Floor Prolapse
Pelvic Organ Prolapse, Menopause
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall.
- Trial name
- PET (NCT01778985)
- Testing
- Premarin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pelvic Organ Prolapse (POP), Uterine Prolapse
Effectiveness of Laparoscopic Lateral Suspension With or Without Hysterectomy in Pelvic Organ Prolapse
This study aims to compare the effectiveness of laparoscopic lateral suspension (LLS) with and without hysterectomy in the treatment of pelvic organ prolapse.
- Trial name
- LLS-HYS (NCT07094815)
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Havva Betül Bacak
Pelvic Organ Prolapse
Pelvic Floor Repair Systems for Prolapse Repair
1. This is a prospective, multi-center, post market study, which will be conducted under a common protocol. 2. The primary objective of the study is to evaluate long-term efficacy of the AMS Pelvic Floor Repair System devices for…
- Trial name
- PROPEL (NCT00638235)
- Testing
- AMS Apogee™ with IntePro, AMS Apogee™ with Intexen LP, AMS Perigee™ with IntePro
- Where
- 28 sites in United States, Belgium and 5 more
- Volunteers
- 725 people
- Sponsor
- ASTORA Women's Health
Pelvic Organ Prolapse
Comparisons of Clinical Outcomes Between Novel Tailored Transvaginal Mesh Surgery and Vaginal Native Tissue Repair Surgery for Pelvic Organ Prolapse
The issue of whether utilizing the mesh in the surgical treatment of pelvic organ prolapse remained undetermined.Thus, the aim of this study is to analyze clinical outcome of women who underwent pelvic organ prolapse surgeries…
- Trial name
- NCT02465710
- Testing
- Pelvic organ prolapse surgery without mesh, Pelvic organ prolapse surgery with mesh
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- National Taiwan University Hospital
Pelvic Organ Prolapse
A Feasibility Study on the Value of Pelvic Floor Training After Pelvic Organ Prolapse Surgery
The main objective is to assess the feasibility of a randomized controlled trial that investigates the effects of pelvic floor training on recurrence in pelvic organ prolapse surgeries.
- Trial name
- NCT04539782
- Testing
- Physiotherapy intervention
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- Landspitali University Hospital
Pelvic Organ Prolapse
Randomized,Multicentric Study to Treat Prolapse After Hysterectomy With Amreich Procedure or Total Prolift Procedure
Head to Head comparison of perioperative complications and secondary the impact of operation techniques with or without mesh on patients suffering from pelvic organ prolapse on quality of life.
- Trial name
- NCT00572702
- Testing
- Vaginal fixation Amreich-Richter, Prolift total
- Where
- 5 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Pelvic Organ Prolapse (POP)
Restorelle Direct Fix Anterior and Posterior (A&P) for Female Pelvic Organ Prolapse: A Prospective Post Market Study
This is a prospective, multi-center study designed to assess the palpability of the Restorelle Direct Fix A\&P mesh after vaginal reconstruction surgery.
- Trial name
- (A&P) (NCT01378065)
- Testing
- Restorelle Direct Fix A&P
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Coloplast A/S
Disability Physical, Urinary Incontinence
Transversus Abdominis and Pelvic Floor Muscle Strengthening Exercise Program In Patients With Grade 1 Cystocele
Cystocele, a protrusion of the bladder, happens while the bladder descends into the vagina. There are more than one underlying causes for the development of cystocele ensuing in weak point of the muscles and the connective tissue…
- Conditions
- Disability Physical, Urinary Incontinence, Prolapse
- Trial name
- NCT05474495
- Testing
- Pelvic floor muscle training, Transverse abdominas strength training
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Prolapse Genital, Prolapse Uterovaginal
Posterior Mesh Fixation at the Levator Ani Level in Apical Pelvic Organ Prolapse
This is a prospective, randomized, multicenter, non-inferiority trial including women with stage II-IV apical pelvic organ prolapse (POP), classified according to the POP-Q system.
- Conditions
- Prolapse Genital, Prolapse Uterovaginal, Prolapse; Female
- Trial name
- FIMEA (NCT07194343)
- Testing
- Laparoscopic colposacropexy with levator ani muscle mesh fixation, Simplified modification of laparoscopic colposacropexy
- Where
- 6 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pelvic Organ Prolapse, Urinary Incontinence,Stress
Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery
This study is a randomized controlled trial designed to assess the rate of failure of voiding trials in the early and late post-operative period within patients who underwent outpatient pelvic floor surgery that failed initial…
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence,Stress, Surgery
- Trial name
- NCT03048682
- Testing
- Foley catheter - Early Voiding Trial, Foley catheter - Late Voiding Trial
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse
Robotic Assisted Sacral Colpopexy : A Prospective Study Assessing Outcomes With Learning Curves
The investigators scientific aims are to determine the benefits associated with the use of robotic assisted laparoscopic sacrocolpopexy surgery on women with prolapse, to define how the benefits impact the patient, physician and…
- Trial name
- NCT01535833
- Testing
- Device- Robotic sacral colpopexy
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Pelvic Floor Disorders
Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse
Anal Acoustic Reflectometry (AAR) is a reliable and reproducible technique that has been studied in our department over the last 6 years.
- Trial name
- NCT02774798
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Manchester University NHS Foundation Trust
Pelvic Organ Prolapse, Urinary Incontinence
Pelvic Floor Disorder Assessment of Knowledge and Symptoms: an Educational Model in Spanish-Speaking Women
Pelvic floor health workshops have previously been shown to be effective in improving postpartum knowledge, performance of pelvic floor muscle exercises, and bowel-specific quality of life.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Patient Education
- Trial name
- PAKS (NCT04829721)
- Testing
- Educational Intervention with video
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Pelvic Organ Prolapse
Effects of Pelvic Floor Muscle Training With & Without Hypopressive Exercises
Pelvic Organ Prolapse (POP) is a prevalent condition affecting women's quality of life due to the descent of pelvic organs caused by weak pelvic floor muscles (PFMs).
- Trial name
- NCT07440875
- Testing
- hypopressive excercises, pelvic training excercises
- Where
- Pakistan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sacral Colpopexy, Pelvic Organ Prolapse
Male Sexual Experience and Its Impact on Quality of Life Before and After Their Sexual Partners Undergo Polypropylene Mesh Augmented Pelvic Floor Reconstruction
The correction of the pelvic organ protrusion is aimed at restoring the pelvic floor functional status and ultimately improving the patient's quality of life.
- Trial name
- SEXQ (NCT01320631)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Pelvic Floor Disorders, Obstetric Trauma
Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth
This is a single-center prospective cohort study sponsored by the University Hospitals Leuven (UZ). Women will undergo a pelvic floor ultrasound and will be asked to fill out a questionnaire at the time of their admission into…
- Conditions
- Pelvic Floor Disorders, Obstetric Trauma, Urinary Incontinence, Anal Incontinence
- Trial name
- DeliverUU (NCT05530681)
- Testing
- Questionnaire, Pelvic floor ultrasound
- Where
- Belgium
- Volunteers
- 320 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pelvic Floor Disorders, Pelvic Organ Prolapse
The Intermediate and Long-term Follow up of Home Based Pelvic Muscle Training
When participants present with symptoms of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), the investigators will perform a comprehensive evaluation and initially provide conservative treatment.
- Conditions
- Pelvic Floor Disorders, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- NCT05778552
- Testing
- Home-based pelvic muscle training devices or traditional PFMT at hospital
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pelvic Organ Prolapse (POP), Synthetic Mesh
Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious)
The purpose of this clinical investigation is to collect clinical data about the ProGYNious Mesh based on a prospective clinical investigation.
- Conditions
- Pelvic Organ Prolapse (POP), Synthetic Mesh, Laparoscopic Surgery, Gynecologic Laparoscopic Surgery
- Trial name
- ProGYNious (NCT07497321)
- Testing
- Surgical mesh for pelvic organ prolapse repair (ProGYNious)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Urinary Incontinence, Pelvic Organ Prolapse
Voiding Assessment Based on Minimum Spontaneous Void of 150 mL Compared to Retrograde Fill Method After Female Pelvic Floor Reconstructive Surgery
This study will compare voiding assessment based on a minimum spontaneous voided volume of 150 cc with the standard retrograde fill approach in women after pelvic floor procedures.
- Trial name
- NCT03539107
- Testing
- Retrograde bladder fill, spontaneous void
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Yale University