Clinical trials: Pediatric Major Surgery
Acute Pain
A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients
The purpose of this study is to demonstrate the efficacy and safety of Intravenous (IV) acetaminophen plus rescue opioids for the relief of moderate to severe acute pain in neonates and infants (age < 2 years) compared to placebo…
- Trial name
- NCT01635101
- Testing
- IV Acetaminophen, IV Control
- Where
- 22 sites in United States
- Volunteers
- 197 people
- Sponsor
- Mallinckrodt
Fluid and Electrolyte Imbalance
RL Versus Glucose Saline in Cancer Patient Undergoing Major Surgeries and Its Impact on Electrolytes, GLC & pH
To compare two electrolytes maintenance in perioperative period in children undergoing major surgeries on perioperative change in pH,lactate,sodium and glucose level
- Trial name
- NCT05810662
- Testing
- Lactated ringer and dextrose 5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Pygopagus Conjoined Twins, Separation Surgery
The Importance of Physiotherapy After Separation Surgery in Pygopagus Conjoined Twins
Motor function delays are observed in pygopagus conjoined twins due to limited movement experience and deficits in proprioceptive sense.
- Conditions
- Pygopagus Conjoined Twins, Separation Surgery, Pediatric Physiotherapy
- Trial name
- NCT06599281
- Testing
- Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people
- Sponsor
- Acıbadem Atunizade Hospital
Spinal Fusion, Cardiopulmonary Bypass
Point of Care Testing in Pediatric Patients Undergoing Major Surgery
The current study proposes to investigate Point of Care Testing (POCT) (Coagcheck®) and compare obtained results versus standard laboratory coagulation parameters prothrombin time (PT) and partial thromboplastin time (PTT).
- Trial name
- NCT01742936
- Testing
- CoaguChek, Hospital Laboratory
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nationwide Children's Hospital
Child
A Comparison of Three Methods of Hemoglobin Monitoring in Pediatric Patients
Investigators compare the accuracy of the SpHb and hemocue with blood Hb levels
- Trial name
- HEMOPED2 (NCT03624140)
- Testing
- blood measurement, pulse co-oxymeter (SpHb), hemoCue
- Volunteers
- 195 people
- Sponsor
- Central Hospital, Nancy, France
Child
A Comparison of Three Methods of Hemoglobin Monitoring in Pediatric Patients Undergoing Major Surgery
Investigators compare the accuracy of the SpHb and hemocue with blood Hb levels
- Trial name
- Hemoped (NCT02634099)
- Testing
- blood measurement, pulse co-oxymeter (SpHb), hemoCue
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Elective Major Abdominal Surgery
Lidocaine Infusion for Major Abdominal Pediatric Surgery
In this study, the investigators hypothesized that perioperative i.v. infusion of lidocaine in major abdominal pediatric surgery, may have a beneficial effect on hemodynamic and hormonal responses.
- Trial name
- NCT01387568
- Testing
- Lidocaine Infusion, saline Infusion
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Blood Coagulation Disorders, Hemorrhage
Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study.
The purpose of this study is to compare two different thromboelastometry (ROTEM) trigger levels for administration of human fibrinogen concentrate (Haemocomplettan P) in the treatment of perioperative dilutional coagulopathy…
- Trial name
- NCT01487837
- Testing
- Human fibrinogen concentrate
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Children's Hospital, Zurich
Obesity
Pilot Study of Laparoscopic Gastric Plication in Adolescents With Severe Obesity
The proposed study aims to investigate the effects of laparoscopic gastric plication (LGP) on excess body weight, body mass index, and weight-related medical and psychological co-morbidities in obese adolescents.
- Trial name
- NCT01980758
- Testing
- Laparoscopic Gastric Plication
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Pediatric Cardiac Surgery, Gender
Gender Influence on Morbi-mortality in Pediatric Cardiac Surgery.
Recent studies show an important influence of gender on inflammatory reactions. Cardiac surgery is associated with a major systemic inflammatory response.
- Trial name
- NCT04452539
- Testing
- Paediatric cardiac surgery
- Where
- Belgium
- Volunteers
- 1,500 people
- Sponsor
- Brugmann University Hospital
Pain
Pharmacogenetic Morphine Spine Study
The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children cope with pain and respond to pain medication.
- Trial name
- NCT01839461
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Intrathecal Dexmedetomidine, Pediatric Cancer Surgery
Intrathecal Dexmedetomidine Versus Fentanyl With Bupivacaine in Children Undergoing Major Abdominal Cancer Surgery
In this study the investigators aim to determine the analgesic effect and side effects of intrathecal fentanyl and dexmedetomidine as adjuvant to local anesthetics in pediatric patients undergoing major abdominal cancer surgeries.
- Trial name
- NCT02861716
- Testing
- Bupivacaine, Fentanyl, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Plasma Volume Substitution (Hypovolemia) Including Massive Hemorrhage
Study to Obtain Volume Effect and Safety Data on 6 % Hydroxyethyl Starch 130/0.4 in Pediatric and Adult Patients Undergoing Major Elective Surgery
The study shall evaluate the volume effect and safety of 6 % hydroxyethyl starch 130/0.4 for restoration and maintenance of hemodynamics during the investigational period in patients undergoing major elective surgery.
- Trial name
- NCT01127477
- Testing
- 1: Hydroxyethyl starch 130/0.4, 6 %
- Where
- 4 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi Japan
Adverse Anesthesia Outcome
Liberal Versus Goal-directed Intraoperative Fluid Therapy in Pediatric Patients
The objectives of this study are 1) to investigate the influence of different fluid regimen (Liberal regimen versus Goal directed therapy regimen) on postoperative outcome such as weight gain, delayed gut function recovery…
- Trial name
- GDT (NCT01350076)
- Testing
- conventional liberal fluid regimen, restricted fluid regimen
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Acute Kidney Injury
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery.
- Trial name
- POAKIDS (NCT07351149)
- Where
- 16 sites in Australia, Brazil and 8 more
- Volunteers
- 2,000 people
- Sponsor
- Uppsala University
Surgery, Anesthesia
Comparing the Effectiveness of Modified ERAS Protocols vs. Standard Management in Pediatric Gastrointestinal Surgery
Perioperative management of pediatric patients with gastrointestinal diseases involves a fairly length process and which can lead to rapid deterioration even death.
- Trial name
- NCT06981572
- Testing
- Modified Enhanced Recovery After Surgery Protocol
- Where
- Indonesia
- Volunteers
- 82 people
- Sponsor
- Universitas Indonesia
Hemolysis
Congenital Heart Surgery in Pediatric Patients With Beta-Thalassemia Major
Authors compared incidence of Hemolysis on Cardiopulmonary Bypass surgery for repair of congenital heart disease in Pediatric Patients between patients with thalassemia major and control group
- Trial name
- NCT04367701
- Testing
- Hemolysis
- Volunteers
- 41 people
- Sponsor
- Ain Shams University
Hypovolemia
Safety Study of Kedbumin 25% Versus Normal Saline in the Treatment of Post-Surgical Hypovolemia in Pediatric Patients
This is a randomized, controlled, open-label clinical trial aimed to evaluate the Safety of Kedbumin 25% Compared to Normal Saline Solution in the Treatment of Post-Surgical Hypovolemia in Pediatric Patients Undergoing Major…
- Trial name
- NCT01531803
- Testing
- Kedbumin 25%, Normal Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Kedrion S.p.A.
Pediatric, Anesthesia
Efficacy of Ultrasound-guided Internal Jugular Vein Versus Supraclavicular Subclavian Vein Cannulation in Neonates and Infants Less Than 5 kg.
The aim of this study is to compare the effectiveness and safety of ultrasound- guided IJV and supraclavicular SCV cannulation in infants weighing less than 5 kg.
- Conditions
- Pediatric, Anesthesia, Central Venous Catheter, Ultrasound
- Trial name
- NCT05956028
- Testing
- Ultrasound guided SCV cannulation, Ultrasound guided IJV cannulation
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Kasr El Aini Hospital
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital