Clinical trials: Pediatric Hypertension
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Pediatric Hypertension
A Phase 3 Long-term Study of TAK-536 in Pediatric Patients 6 to Less Than 16 Years With Hypertension
The purpose of this study is to evaluate the safety of administration of azilsartan in pediatric patients aged 6 to less than 16 years with hypertension.
- Trial name
- NCT02791438
- Testing
- Azilsartan
- Where
- 30 sites in Japan
- Volunteers
- 27 people
- Sponsor
- Takeda
Pulmonary Hypertension
Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension
Pulmonary hypertension (PH) is a consequence of an increase in pulmonary vascular resistance (PVR), pulmonary blood flow, pulmonary venous pressure, or a combination of these elements.
- Trial name
- NCT02595541
- Testing
- milrinone, Sildenafil
- Volunteers
- 30 people
- Sponsor
- Assiut University
Glaucoma
Supracapsular Ahmed Glaucoma Valve Plate Delivery Technique for Management of Encapsulated Bleb in Pediatric Patients
This study aims to assess the safety and efficacy of supracapsular Ahmed Glaucoma Valve plate delivery for management of encapsulated bleb in pediatric patients with failed Ahmed Glaucoma Valve.
- Trial name
- NCT04931290
- Testing
- Supracapsular Ahmed Glaucoma Valve plate delivery technique
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Mansoura University
Hypertension in Adolescence, Adolescent Overweight
Hypertension in High School Students
Hypertension and obesity in the young population are major risk factors for renal and cardiovascular events, which could arise in adulthood.
- Trial name
- HYGEF (NCT06049641)
- Where
- Italy
- Volunteers
- 2,638 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Congenital Heart Disease, Pulmonary Arterial Hypertension
Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension
The purpose of this study is to test the hypothesis that treating PAH-CHD patients preoperatively with PAH drugs and keeping them on treatment for six months after surgery reduces the risk of immediate postoperative death and the…
- Trial name
- NCT01548950
- Testing
- Sildenafil singly or in association with Bosentan
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertension, Pulmonary
Inflammatory Biomarkers of Pediatric Pulmonary Hypertension
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared…
- Trial name
- NCT03581695
- Testing
- Blood test
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Congenital Heart Disease, Pulmonary Hypertension
A Comparative Study of Three Modes of Ventilation During CPB in Pediatrics With Pulmonary Hypertension Undergoing Congenital Heart Surgeries
Aim of Work: The aim of this randomized, double-blinded, study is to compare between three modes of ventilation during cardiopulmonary bypass in pediatric patients with pulmonary hypertension undergoing corrective cardiac…
- Trial name
- NCT04262037
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Hypertension Secondary to Kidney Transplant
Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients
The proposed study investigated the effect of chronotherapeutic alteration of anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric renal transplant recipients who are non-dippers.
- Trial name
- NCT01007994
- Testing
- New Medication: Enalapril, Isradipine, Propranolol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Northwell Health
Childhood Obesity, Type 2 Diabetes
Cardiovascular Risk Factors, Body Composition, Fitness Levels And Quality Of Life In Overweight And Obese 8-17 Year Olds
This project will address the important area of childhood obesity and the risk of cardiovascular disease associated with obesity.
- Conditions
- Childhood Obesity, Type 2 Diabetes, Hypercholesterolemia, Hypertension
- Trial name
- NCT02024399
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Esophageal Varices, Portal Hypertension
Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings
The goal of this observational study: To evaluate the diagnostic accuracy of non-invasive markers in predicting the presence and grading of esophageal varices in children with portal hypertension.
- Trial name
- NCT07464522
- Volunteers
- 51 people
- Sponsor
- Assiut University
Pulmonary Hypertension
Study of Inhaled Iloprost in Pediatric Pulmonary Hypertension (PH) After Surgery
The aim of this study is to determine whether inhaled iloprost can be used to prevent and treat PH and PHC while in children after operation of CHD
- Trial name
- NCT01310751
- Testing
- iloprost nebuliser solusion, distilled water
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension
A Study Of Valsartan Used To Treat Hypertension For Up To 13 Months In Hypertensive Children Ages 6 - 16 Years Of Age
Drugs used to treat high blood pressure in adults should also be effective in treating high blood pressure in children and adolescents.
- Trial name
- NCT00171041
- Testing
- valsartan
- Where
- 2 sites in United States, Germany
- Volunteers
- 265 people
- Sponsor
- Novartis
Hypertension
A Study to Evaluate the Safety/Tolerability and Pharmacokinetics of Aliskiren in Hypertensive Pediatric and Adolescent Patients 6-17 Years of Age
This first open-label study in a pediatric population was designed to evaluate aliskiren safety and pharmacokinetics after single and multiple dosing in 6-17 year old children with hypertension.
- Trial name
- NCT00834041
- Testing
- Aliskiren 3.125 mini-tablets
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 39 people
- Sponsor
- Novartis
Pulmonary Hypertension
Study of Remodulin® in Pediatric Pulmonary Hypertension With Single Ventricular Physiology After Fontan Surgery
The aim of this study is to determine the safety and efficiency of Remodulin®（Treprostinil Injection）to reduce the pulmonary arterial pressure and prevent pulmonary hypertension (PH) after Fontan operation with univentricular…
- Trial name
- NCT02865733
- Testing
- Remodulin, distilled water
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Intracranial Hypertension
Non Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric Age
An increase of intracranial pressure (ICP) is an important cause of secondary brain damage. The gold standard for measuring ICP is represented by invasive positioning of intracranial ICP devices.
- Trial name
- nICPped (NCT05340062)
- Testing
- bedside sonography
- Where
- 6 sites in Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliera di Padova
Pulmonary Arterial Hypertension
Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the safety and effectiveness of iloprost for PAH in children who are between the ages of 3 and 18 years old.
- Trial name
- NCT00453414
- Testing
- Iloprost Inhalation Solution (Ventavis)
- Where
- 2 sites in United States
- Sponsor
- Actelion
Pulmonary Arterial Hypertension
Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension
The primary objective of AC-052-373 was to assess the pharmacokinetic (PK) profile of two dosing regimens of the pediatric formulation of bosentan in children with pulmonary arterial hypertension (PAH) <12 years of age.
- Trial name
- FUTURE 3 (NCT01223352)
- Testing
- bosentan
- Volunteers
- 64 people
- Sponsor
- Actelion
Pulmonary Hypertension
Correlation of Right Atrial Strain With Pulmonary Hypertension, Right Ventricular Function And Outcome In Pediatric Patients
This observational study aims to assess correlation of right atrial strain measured by two-dimensional speckle tracking echocardiography with intraoperatively measured pulmonary artery pressures, other indices of right…
- Trial name
- NCT05699681
- Testing
- Transthoracic and transesophageal echocardiography
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh