Clinical trials: Patients Undergoing General Anesthesia
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Apneic Oxygenation, High-flow Nasal Cannulae
High-flow Nasal Oxygenation in Obese Patients During Apnea
Before going off to sleep patients are given oxygen to saturate blood with oxygen to extend time before a decrease in the level of oxygen in the blood occurs.
- Conditions
- Apneic Oxygenation, High-flow Nasal Cannulae, Bariatric Surgery, Anesthesia Induction
- Trial name
- NCT03195504
- Testing
- HFNC, CON (control)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Remimazolam, Desflurane
Remimazolam vs Propofol as an Induction Agent for Morbid Obesity Patients
It is known that morbidly obese patients are often accompanied by cardiovascular complications such as hypertension, cardiac hypertrophy, and diastolic dysfunction, and are known to increase the risk of hypotension during…
- Conditions
- Remimazolam, Desflurane, Morbid Obesity, Sleeve Gastrectomy
- Trial name
- NCT05856617
- Testing
- Remimazolam besylate
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Seoul National University Bundang Hospital
Analgesia Disorder
Transverse Abdominal Block for Analgesia in Casarean Section
In this study, the investigators will compare the analgesic effect of bupivacaine and bupivacaine-dexmetomedine after elective cesarean delivery by performing an bilateral TAP block, on the patients for whom the operation will be…
- Trial name
- NCT02122510
- Testing
- Bupivacine group, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Hypovolemia
Fluid Responsiveness Using Forehead Sensor in Children
Forehead sensor can predict the more accurate fluid responsiveness than finger sensor in children
- Trial name
- forehead (NCT03132480)
- Testing
- fluid resuscitation
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Pregnancy, Cesarean Delivery
Pharmacogenetics of Remifentanil in Patients With Hypertension Undergoing Cesarean Delivery Under General Anesthesia
Caesarean delivery under general anaesthesia (GA) carries nowadays still 25% risk of insufficient depth of anaesthesia in a time before the fetus delivery. The reason is the lack of opioid administration.
- Conditions
- Pregnancy, Cesarean Delivery, General Anesthesia
- Trial name
- NCT01550640
- Testing
- Remifentanil
- Where
- Czechia
- Volunteers
- 149 people
- Sponsor
- Charles University, Czech Republic
General Anesthesia
Comparison of Deep Neuromuscular Block and Moderate Neuromuscular Block on Quality of Recovery in Patients Undergoing Robotic Gastrectomy
The purpose of this study is to investigate and compare the postoperative quality of recovery between the deep neuromuscular blockade and moderate neuromuscular blockade during robotic gastrectomy.
- Trial name
- NCT02762890
- Testing
- Deep neuromuscular blockade, Moderate neuromuscular blockade
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
General Anesthesia
Comparative Analysis of Phase Lag Entropy (PLE) and Bispectral Index (BIS) as an Anesthetic Depth Indicator
The aim of this comparative analysis is to evaluate the reliability of PLE value as an anesthetic depth indicator
- Trial name
- NCT03424720
- Testing
- PLE and BIS
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Hallym University Medical Center
Stress
Intermediate Cervical Plexus Block on Stress Response
The aim of the present study is to investigate the effect of Bilateral Ultrasound-Guided intermediate cervical plexus Block combined with general anesthesia on the stress and inflammatory response in patients undergoing anterior…
- Trial name
- NCT06064214
- Testing
- u/s guided intermediate cervical plexus block
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Ischemic Stroke
Anesthesia Technique and Outcomes in Mechanical Thrombectomy for Acute Ischemic Stroke
This retrospective cohort study examined clinical outcomes in patients who underwent mechanical thrombectomy for acute ischemic stroke under general anesthesia or sedoanalgesia.
- Trial name
- NCT07422649
- Testing
- General Anesthesia, Sedoanalgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 481 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Phantom Limb Pain, Amputation
Effect of Femoral and Sciatic Nerve Blocks, Combined with General Anesthesia, in Postoperative Pain Levels and Phantom Limb Pain Development in Patients Undergoing Lower Limb Amputation
The goal of this observational study is to determine the effect of femoral and sciatic nerve blocks, combined with general anesthesia, in postoperative pain levels and phantom limb pain development in patients undergoing lower…
- Conditions
- Phantom Limb Pain, Amputation, Anesthesia, Local
- Trial name
- NCT06693427
- Testing
- Peripheral Nerve Block
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- DIMITRIOS KATSAROS
Pain
The Medasense Study
Despite various efforts there is still the need for adequate monitoring of pain and nociception during anesthesia. In a previous protocol the investigators measured pain responses during anesthesia based on single end-points, eg…
- Trial name
- NCT01912118
- Testing
- Propofol, Remifentanil
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Leiden University Medical Center
Residual Neuromuscular Block, Cardiovascular Diseases
Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia
Deep neuromuscular block (DNMB) during laparoscopy induces less haemodynamic stress by facilitating low-pressure pneumoperitoneum.
- Conditions
- Residual Neuromuscular Block, Cardiovascular Diseases, Neuromuscular Blockade Monitoring
- Trial name
- NCT06517524
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Tamas Vegh, MD
Anesthesia, General
A Study to Assess Indices of SNAP vs VISTA on Surgical Patients Undergoing General Anesthesia
Establish the range of index values for the SNAP II corresponding to each anesthetic state studied.
- Trial name
- Precision GA (NCT00829803)
- Testing
- SNAP monitor; Bispectral Index Monitor (BIS Monitor)
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stryker Instruments
Urologic Neoplasms, Benign Prostatic Hyperplasia
Spinal Versus General Anesthesia in Open Simple Prostatectomy
Open simple prostatectomy is still performed for selected patients with benign prostatic hyperplasia, particularly in cases with large prostate volume.
- Conditions
- Urologic Neoplasms, Benign Prostatic Hyperplasia, Anesthesia
- Trial name
- NCT07643415
- Testing
- Spinal anesthesia, General anesthesia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hitit University
General Anesthesia, Aged
Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery
This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing…
- Conditions
- General Anesthesia, Aged, Intraoperative Hypotension, Anxiety
- Trial name
- NCT07746505
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neuromuscular Blockade, Residual Neuromuscular Blockade
Neuromuscular Blockade Monitoring Using Kine-myography vs Electromyography.
This study aims to compare two monitoring methods of neuromuscular blockade - Kine-myography and Electromyography. The main questions to answer are: are electromyography and kine-myography interchangeable is electromyography…
- Trial name
- NCT05992090
- Where
- Czechia
- Volunteers
- 129 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Obesity, Anesthesia
Pre-oxygenation Methods in Bariatric Patients
The purpose of the study is to compare effectiveness of different methods of achieving pre-oxygenation in bariatric patients. The investigators intend to compare facemask pre-oxygenation with a high-flow humidified nasal oxygen.
- Conditions
- Obesity, Anesthesia, Bariatric Surgery Candidate
- Trial name
- NCT03428256
- Testing
- Optiflow and THRIVE technique, Standard anaesthetic face mask
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London