Clinical trials: Pathogenesis
Dementias, Neurodegenerative Dementia
In-depth Analysis of Cholesterol Metabolism and Related Biomarkers in the Pathogenesis and Progression of the Disease in Neurodegenerative Dementias
The aim of the study is to evaluate the role of cholesterol in the pathogenesis of neurodegenerative dementias. Hypercholesterolemia is a known risk factor for Alzheimer disease (AD), and oxysterols, the principal cholesterol…
- Trial name
- RF-2021-123742 (NCT07207486)
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Myositis, Dermatomyositis
Environmental Risk Factors for the Anti-synthetase Syndrome
Background: Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors.
- Conditions
- Myositis, Dermatomyositis, Polymyositis, Juvenile Dermatomyositis
- Trial name
- NCT01276470
- Where
- 8 sites in United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Nephropathy, Oxidative Stress
Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy
With the wide use of contrast agents in clinical diagnosis and treatment, contrast induced nephropathy(CIN) accounts for 1/3 of hospital acquired acute renal failure.The mortality rate of patients with CIN is up to 35%,and about…
- Trial name
- NCT01142024
- Testing
- Glutathione, saline
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Mucolipidosis Type IV
The Natural History and Pathogenesis of Mucolipidosis Type IV
Mucolipidosis Type IV (ML-IV) is a metabolic disorder that causes mental and motor retardation as well as visual impairment. There is storage of material in practically all the cells of the body, causing problems in the brain and…
- Trial name
- NCT00015782
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tuberculosis
Paradoxical Tuberculosis Reactions in Patients Without HIV Infection
Background: Most people with tuberculosis (TB) feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This is a paradoxical reaction.
- Trial name
- NCT04052022
- Where
- 3 sites in United States, Mexico
- Volunteers
- 140 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ischaemic Stroke
Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died.
- Trial name
- NCT01665729
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Li Haiyan
Type 2 Diabetes Mellitus
The Role of Vitamin D3 and Calcium Supplementation in Attenuating T2DM Severity
The purpose of this study is to investigate the effect of vitamin D3 and calcium supplementation in attenuating type 2 diabetes mellitus outcomes in ethnic diverse, diabetic patiens.
- Trial name
- NCT02464462
- Testing
- vitamin D3 and calcium
- Volunteers
- 11 people
- Sponsor
- York University
Type 1 Diabetes Mellitus
Endothelial Dysfunction and Diabetes
The aim of the study is to progress in the understanding of the early retinal vascular and neural abnormalities in patients with diabetes, using a new device, the Dynamic Vessel Analyzer.
- Trial name
- DENDI (NCT01097551)
- Testing
- Trinitrin, Neosynephrine 10% collyrium, Iontophoresis with acetylcholine delivery
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Age-Related Maculopathy
Study Evaluating Genotypes Using Lucentis
The purpose of the study is to investigate whether the efficacy of Lucentis treatment for exudative age-related macular degeneration is associated with VEGF and HTRA1 DNA polymorphisms
- Trial name
- SEAGUL (NCT00474695)
- Testing
- Lucentis
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Utah
Diabetic Macular Oedema
Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema)
Diabetic macular oedema is characterized by fluid accumulation in the retinal tissue from leaking retinal vessels, the capillaries. This state can lead to severe visual loss and blindness.
- Trial name
- NCT00333671
- Testing
- Glycerol
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Pre-diabetes
Incretins in Impaired Fasting Glucose
People with high fasting glucose can develop type 2 diabetes with the passage of time. This study is being done to determine the effect of a novel medication in people with this elevated fasting glucose.
- Trial name
- NCT00364377
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Lactic Acidosis, Metformin
Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis
Metformin is the first line drug of choice for the treatment of type II diabetes. Lactic acidosis can develop as a side effect, especially when renal failure leads to drug accumulation.
- Trial name
- NCT00942123
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
NSSI
The Muti-centered Investigation，Pathogenesis and Intervention Study of Non-suicidal Self-injury Behavior in China
Non-suicidal self-injury (NSSINSSINSSI) refers to a series of direct and consequently repeated injuries to one's body without suicidal intent. At present, it has become an important issue of mental disorders.
- Trial name
- NCT04094623
- Testing
- Dialectical behavior therapy, Social support group therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing Medical University
Tumor Induced Oncogenic Osteomalacia
Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia
The tumors that cause oncogenic osteomalacia (TIO) express and release in the circulation phosphaturic factors such as fibroblast growth factor-23 (FGF-23) that decrease renal phosphate absorption through acting in the proximal…
- Trial name
- NCT02331966
- Where
- Greece
- Volunteers
- 10 people
- Sponsor
- AHEPA University Hospital
Diabetes
Neuropsychiatric Factors
It is estimated that approximately 20-25% of diabetic patients will have at least one trophic disorder during their period. The appearance of a trophic disorder in a diabetic patient is a serious complication, indicating that…
- Trial name
- Diapepsy (NCT03323281)
- Testing
- Neuropsychological assessments
- Where
- France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
Characteristic Study on Chinese Patients With Multiple Sclerosis
Compared with MS in white populations, in people of China descent multiple sclerosis (MS)is characterized by lower prevalence, more frequent and severe involvement of the visual system at onset and during the entire clinical…
- Trial name
- NCT00818103
- Testing
- atorvastatin, β-interferon, EPO
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Sun Yat-sen University
Vaginosis, Bacterial
Pathogenesis of Bacterial Vaginosis in Women Who Have Sex With Women
The objectives of this study are to: (1) use cultivation-independent molecular methods to determine the sequence of microbiological events culminating in bacterial vaginosis (BV) among sexually active African American women who…
- Trial name
- NCT02272231
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Inflammatory Bowel Disease, Crohn's Disease
SSAT 054: Non Genetic Factors in the Pathogenesis of IBD in Twins
This study aims to investigate the role of non-genetic factors in the pathogenesis of inflammatory bowel disease.An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02383953
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Nervous System Malformations, Arthropathy, Neurogenic
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
This study will evaluate the safety and effectiveness of anakinra (Kineret) for treating patients with neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurological, cutaneous and…
- Conditions
- Nervous System Malformations, Arthropathy, Neurogenic, Urticaria, Papilledema
- Trial name
- NCT00069329
- Testing
- anakinra
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)