Clinical trials: Paroxysmal Atrial Fibrillation (PAF)
Paroxysmal Atrial Fibrillation
Atrial Electromechanical Function in Endurance Athletes With and Without Atrial Fibrillation
This study evaluates cardiac structure and function differences between healthy endurance trained athletes with atrial fibrillation and healthy age matched endurance trained athletes without atrial fibrillation.
- Trial name
- NCT03305744
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Paroxysmal Atrial Fibrillation, Atrial Arrhythmia
Effectiveness Study of Circumferential vs. Segmental Ablation in Paroxysmal Atrial Fibrillation
This is a PI-initiated study that aims to evaluate the efficacy of two different methods of paroxysmal atrial fibrillation (PAF) ablation.
- Trial name
- PAF (NCT02106663)
- Testing
- Circumferential Pulmonary Vein Ablation, Segmental Pulmonary Vein Isolation
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of California, San Diego
Paroxysmal Atrial Fibrillation
Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation
The objective of this study is to demonstrate that the NAVI-STAR THERMO-COOL catheter can be used to safely and effectively reduce symptomatic episodes of paroxysmal atrial fibrillation in patients with frequent (>3…
- Trial name
- NCT00584415
- Testing
- GP ablation + PV isolation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Oklahoma
Paroxysmal Atrial Fibrillation (PAF)
Sustained Treatment of Paroxysmal Atrial Fibrillation Post-Approval Study (STOP AF PAS)
The Post-Approval Study (PAS) is a prospective multi-center, non-randomized, single arm, controlled,unblinded clinical study designed to provide long-term safety and effectiveness of the Arctic Front® Cardiac CryoAblation System.
- Trial name
- STOP AF PAS (NCT01456949)
- Testing
- Medtronic Arctic Front® Cardiac CryoAblation System
- Where
- 39 sites in United States, Canada
- Volunteers
- 402 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation
Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes
The primary purpose of this study is to assess the efficacy of oral prednisone in improving the outcomes of pulmonary vein isolation with radiofrequency ablation.
- Trial name
- NCT01206452
- Testing
- Prednisone, Ablation Procedure
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Paroxysmal Atrial Fibrillation
THERMOCOOL SMARTTOUCH®SF Catheters With Ablation Index Study
A single-center, real word study of consecutive subjects who undergo radiofrequency ablation for paroxysmal AF using THERMOCOOL SMARTTOUCH®SF (STSF) Catheter guiding by Ablation Index (AI).
- Trial name
- STSF (NCT03963349)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Biosense Webster, Inc.
Paroxysmal Atrial Fibrillation
Balloon Cryoablation Without Contrast
Pulmonary vein isolation using cryoballoon ablation is well established method for the treatment of atrial fibrillation. As a rule, cryoenergy delivery is preceded by documenting the full vein occlusion.
- Trial name
- CRY-OUT-CAT (NCT04344743)
- Testing
- Cryoballoon ablation without contrast
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Medicover Hospital
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Model Based Fast Anatomical Mapping
This prospective, multicenter observational study will examine the ability of model based fast anatomical mapping (mFAM) to create left atrial (LA) geometry for atrial fibrillation ablation.
- Trial name
- MFAM (NCT03349476)
- Testing
- MFAM
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation (AF), Paroxysmal AF
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
The objective of this clinical investigation is to evaluate the feasibility, safety, and effectiveness of a concomitant procedure involving the Volt PFA System and Amulet 2 device in patients indicated for both AF ablation and…
- Conditions
- Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation
- Trial name
- CLEAR (NCT07523620)
- Testing
- PVI Ablation, Left Atrial Appendage Occluder Implant
- Where
- 16 sites in Belgium, Czechia and 8 more
- Volunteers
- 240 people
- Sponsor
- Abbott Medical Devices
Paroxysmal Atrial Fibrillation
Computed Tomogram Myocardial Thickness Map Guided pulmOnary Vein iSolaTion vs. Empirical Pulmonary Vein Isolation in Cryoballoon Ablation for Paroxysmal Atrial Fibrillation (UTMOST AF II)
New parameters or methods, such as ablation index, have been developed for the quantification of high-frequency energy used in pulmonary vein isolation, but there is no known method for atrial fibrillation considering individual…
- Trial name
- NCT03912324
- Testing
- Unipolar voltage subtraction map guided PV isolation group, CT myocardial thickness map guided PV isolation group, Empirical PV isolation group
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Yonsei University
Paroxysmal Atrial Fibrillation
NAVISTAR® THERMOCOOL® Catheter Post Approval Registry
The purpose of this registry is to provide additional corroborative short-term safety and long-term safety data for the NAVISTAR THERMOCOOL and NAVISTAR EZ STEER THERMOCOOL catheters in the treatment of symptomatic Paroxysmal…
- Trial name
- AF Registry (NCT00964392)
- Testing
- Atrial fibrillation ablation
- Volunteers
- 437 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
A Study For Treatment of Paroxysmal Atrial Fibrillation (PAF) With the OMNYPULSE Catheter and the TRUPULSE Generator
The purpose of this study is to demonstrate safety and effectiveness of the ablation system (OMNYPULSE Bi-directional catheter and TRUPULSE generator) when used for isolation of the atrial pulmonary veins (PVs) in treatment of…
- Trial name
- Omny-IRE (NCT05971693)
- Testing
- OMNYPULSE Bi-Directional Catheter with TRUPULSE Generator
- Where
- 13 sites in Belgium, Canada and 6 more
- Volunteers
- 188 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation, Paroxysmal Atrial Fibrillation
MultiPulse Therapy (MPT) for AF (US)
Assess the clinical safety and feasibility of MultiPulse Therapy (MPT) electrical stimulation waveform sequence in terminating paroxysmal and persistent atrial fibrillation.
- Conditions
- Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
- Trial name
- NCT05055921
- Testing
- Multi Pulse Therapy as delivered from the Cardialen External Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Cardialen, Inc.
Atrial Fibrillation (Paroxysmal), Atrial Fibrillation (AF)
Systematic Workflow for Pentaspline Pulsed-field Ablation Optimization
While radiofrequency and cryoballoon ablation have shown high rates of pulmonary vein reconnection in patients undergoing repeat electrophysiological evaluation for AF recurrence, early evaluations demonstrated a remarkably high…
- Conditions
- Atrial Fibrillation (Paroxysmal), Atrial Fibrillation (AF), Ablation of Atrial Fibrillation
- Trial name
- SWEET P-PFA (NCT06706518)
- Testing
- Single-shot ablation technologies
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Daniel Rodríguez Muñoz
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
AF Septal Pacing (Clinical Investigation Plan)
The purpose of this non-randomized, non-controlled, acute, single-arm research study is to evaluate the feasibility to obtain a stable position of a ring of stimulation electrodes on the interatrial septum.
- Trial name
- NCT03242941
- Testing
- Pulmonary vein ablation
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 16 people
- Sponsor
- Medtronic BRC
Symptomatic Paroxysmal Atrial Fibrillation (PAF)
FIRE AND ICE: Comparative Study of Two Ablation Procedures in Patients With Atrial Fibrillation
Comparing efficacy and safety of isolation of the pulmonary veins (PV) using a Cryoballoon catheter versus a radiofrequency ablation with a ThermoCool catheter in patients with paroxysmal atrial fibrillation.
- Trial name
- NCT01490814
- Testing
- Electrical isolation of the pulmonary veins, Electrical isolation of pulmonary veins
- Where
- 19 sites in Czechia, France and 6 more
- Volunteers
- 769 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Rapid Arrhythmia, PFA
Clinical Study on the Safety and Efficacy of a New Magnetic Navigation Radiofrequency Ablation Catheter for Rapid Arrhythmia
Clinical study on the safety and efficacy of FireMagic™ Magbot Ablation Catheter for rapid arrhythmia
- Conditions
- Rapid Arrhythmia, PFA, Symptomatic Supraventricular Tachycardia
- Trial name
- Rapid arrhythm (NCT07067372)
- Testing
- FireMagic™ Magbot Ablation Catheter
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.
Atrial Fibrillation, Permanent Atrial Fibrillation
Accelerated Pacing in Patients Undergoing Pace-and-ablate Strategy With LBBAP: a Randomized Controlled Pilot Trial
The goal of this clinical trial is to determine the effect of accelerated pacing (pacemaker lower rate programmed to 80bpm) compared to pacing at the standard programmed lower rate of 60bpm in symptomatic atrial fibrillation…
- Conditions
- Atrial Fibrillation, Permanent Atrial Fibrillation, Persistent Atrial Fibrillation, Pacemaker DDD
- Trial name
- PACE-AF (NCT06377046)
- Testing
- Accelerated pacing, Current standard of care
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation
High Power Short Duration Ablation for Paroxysmal AF With High Density Multi Directional Mapping (LOWE AF HD Study).
The LOWE AF HD is a prospective, single-center, non-randomized study to assess safety, efficacy, acute and long-term outcome data of a specific ablation approach as treatment of paroxysmal atrial fibrillation.
- Trial name
- LOWE-AF-HD (NCT04362683)
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- Gregorio Covino
Atrial Fibrillation
Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation
A prospective, single-arm, single-center study to evaluate the safety, performance, and effectiveness of the SpherePVI™ Catheter for treating paroxysmal AF.
- Trial name
- SpherePVI (NCT05144503)
- Testing
- SpherePVI™ Catheter
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Medtronic Cardiac Ablation Solutions