Clinical trials: Parodontitis, active
Asymptomatic Apical Periodontitis
Effects of Intracanal Cryotherapy on Biomarkers and Postoperative Pain in Apical Periodontitis
This randomized controlled clinical study will evaluate the effects of intracanal cryotherapy during root canal treatment in patients with asymptomatic apical periodontitis.
- Trial name
- NCT07850219
- Testing
- Temperature-Controlled Intracanal Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Medipol University
Periodontitis
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control…
- Trial name
- GBT (NCT06726902)
- Testing
- GBT and SI with erythritol powder, GBT and SI with glycine powder, GBT and SI with trehalose powder
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Diana Ibrahim
Periimplantitis, Periodontitis
Evaluation of the Effects of Routine Phase I Periodontal Therapy on Clinical Parameters and Levels of Gremlin-1, CTHRC1, and Tenascin-C in Gingival Crevicular Fluid and Peri-Implant Sulcular Fluid in Individuals With Periodontitis and Peri-Implantitis
The aim of this study is to compare the mechanisms of tissue destruction between natural teeth with periodontitis and implants with peri-implantitis within the same individual, and to evaluate the effects of routine Phase I…
- Trial name
- NCT07797127
- Testing
- Routine Phase I Non-Surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Pulp Necrosis, Apical Periodontitis
Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic…
- Trial name
- NCT07897591
- Testing
- Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Periodontitis, Furcation Defects
Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects
The aim of this randomized clinical trial is to evaluate the potential benefit of the use of a bone substitute material in the treatment of furcation degree II-involved molars.
- Trial name
- NCT06270303
- Testing
- Access flap & surgical debridement, Application of bone substitute material (BioOss Collagen)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
Dental Caries (Diagnosis), Dental Plaque (Diagnosis)
Assessment of Dental Pathologies Using Digital Tools
Digital technology is playing an increasingly important role in dentistry, because of its ability to support the practitioner and increase work efficiency.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque (Diagnosis), Periodontitis
- Trial name
- RESTODATA-NUM (NCT07205588)
- Where
- 22 sites in France, Reunion
- Volunteers
- 350 people
- Sponsor
- Recherche Clinique en Odontologie (ReCOL)
Chronic Apical Periodontitis
Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis
The aim of this study is to evaluate the effects of different irrigation protocols using ethylenediaminetetraacetic acid (EDTA) and etidronic acid (HEBP) on periapical lesion healing and postoperative pain in single-rooted…
- Trial name
- NCT07353008
- Testing
- Final irrigation with 2.5% NaOCl and 17% EDTA, Final irrigation with 2.5% NaOCl and 9% HEBP, Irrigation with 2.5% NaOCl-9% HEBP during both preparation and final irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Periodontitis, Pocket, Periodontal
Diode Laser as an Adjunct to Professional Mechanical Plaque Removal
This study will utilize diode laser to determine its effects on improving periodontal parameters and inflammatory biomarkers, comparing with conventional treatment alone, and evaluate its effectiveness in improving periodontal…
- Trial name
- NCT06719674
- Testing
- Professional mechanical plaque removal and Laser, Professional mechanical plaque removal
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Sulaimani
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Intracanal Dressing, Apical Periodontitis
Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: Intensity of postoperative pain levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers
- Trial name
- NCT07101029
- Testing
- Bio-C Temp Intracanal Medication, Calcium Hydroxide Intracanal medication
- Volunteers
- 30 people
- Sponsor
- Cairo University
Periodontitis
Periodontitis and Inflammation: Study on Biological Samples
Periodontitis is a major public health problem because it is widespread in the adult population. It leads to the irreversible destruction of the anchoring tissues of the teeth, and represents a modifiable risk factor for systemic…
- Trial name
- CB-PARO2 (NCT06012019)
- Testing
- Biological sampling in Periodontitis Case, Biological sampling in Gingivitis Case, Biological sampling in Control Case
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post Endodontic Pain, Periapical Healing
Comparative Evaluation of Endodontic Instrumentation Kinematics and Cryotherapy on Post-endodontic Pain and Periapical Healing
TITLE : Comparative evaluation of two different endodontic instrumentation kinematics and cryotherapy on post endodontic pain and periapical healing in teeth with asymptomatic apical periodontitis - A double blind, prospective…
- Trial name
- NCT07500870
- Testing
- rotary instrumentation kinematics, reciprocating instrumentation kinematics
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Kidney Disease, Periodontitis
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions.
- Conditions
- Chronic Kidney Disease, Periodontitis, End Stage Renal Disease (ESRD)
- Trial name
- NCT07635797
- Testing
- Subgingival Instrumentation, Oral Hygiene Instructions
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Periodontal Diseases
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
Three techniques for periodontal reconstruction will be compared, in which marginal access versus apical access will be carried out.
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket
- Trial name
- NCT03997552
- Testing
- Non-incised papillae surgical approach (NIPSA), marginal approach by palatal incision, Minimally invasive surgical technique (MIST)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Murcia
TMJ, Apical Periodontitis
Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning
The aim of the present study is to show that the use of 0.55T MRI combined with a "dental" coil produces images of sufficient diagnostic value to assess areas of interest in dentistry, and to compare MR images to traditional…
- Conditions
- TMJ, Apical Periodontitis, Periodontal Inflammation, Retained Tooth
- Trial name
- NCT05439330
- Testing
- MRI of teeth and surrounding structures
- Where
- Denmark
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Periodontitis Stage II, Periodontitis Stage III
Development and Validation of the Periodontal Map Derived From IOS and CBCT Registration for Diagnosis and Treatment Planning in Moderate-to-severe Periodontitis
This prospective diagnostic study aims to validate the clinical utility of a "Periodontal Panoramic Map" generated by the PerioAI V2.0 system, an artificial intelligence-based platform that integrates intraoral scans and…
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- NCT07505251
- Testing
- Perio AI V2.0 System
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Revascularization
Regeneration of Immature Teeth. Case Series
This clinical study aims to investigate the predictability of revascularization procedure of immature necrotic human permanent teeth with apical periodontitis.
- Trial name
- NCT03507556
- Testing
- Triple paste and induced bleeding, Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol
- Where
- Jordan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology