Clinical trials: Parodontitis
Periodontitis, Smoking ( Cigarette)
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis.
- Trial name
- NSPT-Biomarker (NCT07547202)
- Testing
- Non-surgical periodontal therapy (Scaling and root planing)
- Where
- 2 sites in Iraq
- Volunteers
- 44 people
- Sponsor
- Al-Mustansiriyah University
Periodontitis
Periodontitis Severity and Associated Factors Among Egyptian Males and Females
This cross-sectional study aims to evaluate and compare the severity of periodontitis between a group of Egyptian males and females.
- Trial name
- NCT07721337
- Testing
- Clinical Periodontal Examination and Questionnaire
- Where
- Egypt
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontitis
Validation of the Clinical and Antimicrobial Effectiveness of a Clorexidine and Sodium DNA Based Mouthwash in Patients With Stage III and IV Periodontitis
Sodium DNA has several properties that may be beneficial in the management of bacterial biofilm in periodontitis. The aim of this RCT study is to clinically evaluate the antimicrobial and oral biofilm control properties of two…
- Trial name
- NCT06028867
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Catania
Post Operative Pain, Apical Periodontitis
Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth
This randomized clinical trial aimed to evaluate post-operative pain (PP) in single-rooted teeth with asymptomatic apical periodontitis following final irrigation with sonic activation systems (EDDY and EndoActivator), with and…
- Conditions
- Post Operative Pain, Apical Periodontitis, Asymptomatic Infections
- Trial name
- NCT07170098
- Testing
- EDDY sonic irrigation system, EndoActivator (EA) sonic irrigation system, 980-nm diode laser
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontitis, Laser
Clinical Evaluation of the Effect of LANAP as an Adjunct Treatment in Management of Patients With Chronic Periodontitis
this study evaluate the effect of LANAP (Laser Assisted New Attachment Procedure) as an Adjunct Treatment in Management of Patients With Chronic Periodontitis and assay the effect of LANAP on periodontal indexes like BOP, CAL…
- Trial name
- NCT03365167
- Testing
- LANAP (Laser Assisted New Attachment Procedure), LANAP off
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Chronic Periodontitis
Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis
This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.
- Trial name
- NCT05005767
- Testing
- scaling and root planing, Frankincense extract gel natural herbal product
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Stable Angina Pectoris, Periodontitis
Effect of Periodontal Therapy on Asprosin in Stable Angina
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis.
- Trial name
- NCT07591844
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Infra-bony Periodontal Defect
Effect of Gingival Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Management of Infra-bony Periodontal Defect
The goal of the study to evaluate whether the adjunctive use of gingival mesenchymal stem cell-derived extracellular vesicles (GMSC-derived EVs) combined with β-tricalcium phosphate (β-TCP) and a collagen membrane results in…
- Trial name
- NCT07867067
- Testing
- Gingival mesenchymal stem cell derived small extracellular vesicles, β-calcium triphosphate (β-TCP) + collagen membrane
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Ain Shams University
Periodontitis, Gingivitis
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions
In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06558136
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Chronic Kidney Disease Stage 5, Periodontitis
Effect of Non-surgical Periodontal Treatment and C-reactive Protein Levels in Hemodialysis Patients
The presence of periodontitis has been hypothesized as a risk factor for several systemic outcomes, including chronic kidney disease (CKD).
- Trial name
- NCT04262011
- Testing
- immediate treatment, postponed treatment
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Santa Maria
Chronic Periodontitis
1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis
Background: Statins are the recently evolved agents that aid in periodontal regeneration and ultimately attaining periodontal health.
- Trial name
- NCT02060032
- Testing
- 1.2% Atorvastatin local drug delivery, 1.2% simvastatin local drug delivery
- Volunteers
- 96 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects
The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone…
- Trial name
- NCT05886699
- Testing
- PRP combined with DFDBA, DFDBA
- Where
- India
- Volunteers
- 13 people
- Sponsor
- Government Dental College and Hospital, India
Chronic Apical Periodontitis
Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection.
- Trial name
- NCT07892690
- Testing
- Cyperus articulatus
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Asymptomatic Apical Periodontitis
Effect of Calcium-Based Bioceramic Sealer and Resin-Based Sealer on Postoperative Pain
This study aims to compare the effect of calcium-based bioceramic sealer and resin-based sealer on postoperative pain in adult patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07256691
- Testing
- Resin-based sealer obturation technique, Bioceramic sealer obturation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Fatima Memorial Hospital
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)
The purpose of this research study is to find out about the effect of growth factors extracted from blood on improving healing of periodontal pockets (Gum pockets) after deep gum cleaning.
- Trial name
- NCT04978324
- Testing
- leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Apical Periodontitis
Endodontic Microsurgery
Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched.
- Trial name
- EMS (NCT06776289)
- Testing
- Platelet rich fibrin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mark Schachman
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Post Operative Pain
Postoperative Pain After Using Different Single-File Glide Path Systems
This study aimed to evaluate postoperative pain intensity after glide-path preparation with the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.Maxillary and…
- Trial name
- NCT05955742
- Testing
- Control, ProGlider, WaveOne Gold Glider
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Periodontal Diseases, Periodontitis
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy
This prospective cross-sectional study evaluates the frequency and risk factors of periodontal disease in head and neck cancer patients who have undergone radiotherapy.
- Trial name
- NCT06667362
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Ain Shams University
Aggressive Periodontitis
Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
The purpose of this study is to determine whether full-mouth disinfection is effective in the initial periodontal treatment of generalized aggressive periodontitis on clinical parameters, gingival crevicular fluid interleukin-1β…
- Trial name
- NCT02466646
- Testing
- Klorhex® Gel, rinse and spray, Conventional IPT, Full-mouth IPT
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University