Clinical trials: Parkinsons Disease
Parkinson's Disease
The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disorder occurring in 7 million patients worldwide. PD is caused by progressive loss of nigro-striatal dopamine cells, which causes motor symptoms such as slowness of…
- Trial name
- MIND-PD (NCT05779137)
- Testing
- MBCT
- Where
- Netherlands
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Strategy for Daily Activity Improvement in Patients With Parkinson's Disease
The symptoms and signs of patients with Parkinson's disease (PD) include bradykinesia, rigidity, tremor and poor sensory integration, which result in mobility disability.
- Trial name
- Parkinson (NCT03972241)
- Testing
- foot insole
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kwan-Hwa Lin
Idiopathic Parkinson's Disease
PF-06669571 In Subjects With Idiopathic Parkinson's Disease
This study is designed to assess safety, tolerability and pharmacokinetic data for multiple doses of PF-06669571 in subjects with idiopathic Parkinson's disease.
- Trial name
- NCT02565628
- Testing
- PF-06669571
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Parkinson's Disease
Telemedicine Intervention to Improve Physical Function
This project is investigating whether a one-year in-home exercise program will reduce the rate of falls and improve strength and quality of life in patients with Parkinson's disease.
- Trial name
- NCT01639469
- Testing
- Structured exercise, Lifestyle exercise
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- VA Office of Research and Development
PARKINSON DISEASE (Disorder), Parkinson
Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD).
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson s Disease, Parkinson Disease
- Trial name
- Syn-G (NCT07217054)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CND Life Sciences
Parkinson Disease, Parkinson
Treatment Burden in Parkinson's
Background: People with Parkinson's (PwP) have many symptoms including tremor, stiffness, slow movements, constipation, urinary incontinence and mental health issues.
- Trial name
- NCT04769973
- Where
- 2 sites in United Kingdom
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southampton
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for the early differentiation of Parkinson's disease (PD) from atypical parkinsonian…
- Conditions
- PARKINSON DISEASE (Disorder), Atypical Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
- Trial name
- BIOMARK-PS (NCT07604883)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Molecular and Cell Biology in Warsaw
Parkinson Disease, Deep Brain Stimulation
Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation
The goal of this clinical trial is to evaluate whether Mediterranean diet can help manage body weight and improve body composition in adult Parkinson's disease patients who have undergone bilateral subthalamic nucleus deep brain…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Deep Brain Stimulation Surgery
- Trial name
- NCT07187739
- Testing
- Mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara University
Parkinson Disease
Asleep MRI-guided Versus Awake Microelectrode Recording Guided Deep Brain Stimulation in Parkinson's Disease: A Comparative Effectiveness Trial
Rationale: Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-accepted treatment for Parkinson's disease (PD).
- Trial name
- ACCURATE (NCT05453331)
- Testing
- bilateral STN deep brain stimulation
- Volunteers
- 158 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)
The study will investigate the biomarker of a-synuclein aggregate in CSF detected by protein misfolding cyclic amplification (PMCA) and its sensitivity and specificity in diagnosing Parkinson's disease at H-Y stage I and disease…
- Trial name
- NCT04536857
- Testing
- Biomarker assay
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Huashan Hospital
Basal-ganglia fMRI Neurofeedback
Brain Self-regulation for Parkinson's
To investigate feasibility of basal-ganglia regions as fMRI-neurofeedback targets in Parkinson's patients and evaluate self-regulation success
- Trial name
- Brain-REG (NCT05627895)
- Testing
- Neurofeedback
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University
Parkinsons Disease (PD), Anxiety
TMS in Anxiety-Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Anxiety in PD is common, has major effects on quality of life and contributes to increased disability.
- Trial name
- NCT06999330
- Testing
- Theta burst stimulation active coil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute
Parkinson's Disease, Mild Cognitive Impairment
Cognitive Rehab for Parkinson's
This study will examine the feasibility of an at-home cognitive training program that incorporates both memory training and online computerized cognitive training (CCT) software.
- Trial name
- NCT03836963
- Testing
- cognitive training, active control cognitive training, memory strategy training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Constipation, Parkinson Disease
Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease
Constipation is a common complication and non-motor symptom of Parkinson's disease (PD) and affects up to 80% of people with PD.
- Trial name
- Food4PD (NCT06697626)
- Testing
- Inulin, B-vitamins and vitamin D
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Ulster
Parkinson's Disease; Deep Brain Stimulation
Investigating the Pathophysiological Roles of Cortical, Sub-thalamic Nuclear and Pedunculo-pontine Nuclear Oscillation in Movement Termination of Parkinson Disease Patients
The ERD and ERS patterns of coordination between the STN and cortical regions in the termination of volitional movement in PD patients.
- Trial name
- NCT01774383
- Where
- Taiwan
- Volunteers
- 3 people
- Sponsor
- China Medical University Hospital
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Parkinson Disease
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease
BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic…
- Trial name
- BioGenPark (NCT05384522)
- Testing
- blood samples collection
- Volunteers
- 103 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Deep Brain Stimulation, Parkinson Disease
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease.
- Trial name
- CLOSE-PD (NCT06909045)
- Testing
- Adaptive DBS, Continue DBS
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parkinson Disease
Adaptive Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn if adaptive deep brain stimulation (DBS) can decrease or prevent freezing of gait in participants with Parkinson's disease.
- Trial name
- NCT06819020
- Testing
- Percept RC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Doris Wang, MD, PhD
PARKINSON DISEASE (Disorder)
Whole-Body Vibration Exercise in Patients With Parkinson's Disease
This study is a prospective, single-blind, randomized controlled trial designed to investigate the effects of whole-body vibration (WBV) exercise on balance, mobility, fall risk, and proprioception in patients with Parkinson's…
- Trial name
- NCT07472946
- Testing
- Whole-Body Vibration Plus Home Exercise, Home Exercise Only
- Volunteers
- 68 people
- Sponsor
- Istanbul University
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