Clinical trials: Parkinson
Parkinson Disease
Interdisciplinary + Intersectoral Telemedicine Evaluation, Coordination + Treatment in RhineMain+ Parkinson's Network
Project objective: To improve the health care of Parkinson's disease patients in the ParkinsonNetz RheinMain+. Hypothesis: Through the interdisciplinary and cross- sectoral networking in a tele medical network and the…
- Trial name
- INSPIRE-PNRM (NCT06479083)
- Testing
- New Intervention form including, Standard treatment
- Where
- 2 sites in Germany
- Volunteers
- 1,354 people
- Sponsor
- Johannes Gutenberg University Mainz
Parkinson Disease, Huntington Disease
Measuring Cortisol Levels in Persons With Parkinson's (PD)
The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls.
- Trial name
- CORT-PD (NCT02727270)
- Testing
- No Intervention - Observational Study
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson's Disease, Visual Hallucinations
Role of Retina in Mechanisms of Illusions and Visual Hallucinations Observed in Idiopathic Parkinson's Disease
Parkinson's disease is characterized not only by motor symptoms but also by psycho-behavioral symptoms including Visual Hallucinations (VH) and illusions (I), that are generally associated with a severe functional impairment and…
- Trial name
- NCT03454269
- Testing
- Optical Coherence Tomography
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson´s Disease
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk.
- Trial name
- NCT01391741
- Testing
- Visual Cues, Walking without visual cues
- Where
- Iceland
- Volunteers
- 26 people
- Sponsor
- University of Iceland
Parkinson's Disease
Trial of Ursodeoxycholic Acid (UDCA) for Parkinson's Disease: The "UP" Study
The aim of this study is to explore the potential of Ursodeoxycholic acid (UDCA) to slow down the progression of Parkinson's Disease (PD) in a randomised, double-blind, placebo-controlled, "proof of concept" study.
- Trial name
- NCT03840005
- Testing
- Ursonorm
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Parkinson's Disease (PD)
Immediate Effects of External Trigeminal Nerve Stimulation on Motor Dysfunction in Parkinson's Disease
Parkinson's disease (PD), the most common movement disorder, is characterized by motor symptoms including tremor, rigidity, bradykinesia, and postural instability.
- Trial name
- NCT07656129
- Testing
- external Trigeminal Nerve Stimulation, eTNS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhengli Di
Non-Small-Cell Lung Carcinoma
Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)-Japan Extension Study
This is a Japan Extension Study of Global Study MK-3475-189 (NCT02578680). This is an efficacy and safety study of pembrolizumab (MK-3475) combined with pemetrexed/platinum chemotherapy versus pemetrexed/platinum chemotherapy…
- Trial name
- NCT03950674
- Testing
- Pembrolizumab 200 mg, Cisplatin, Carboplatin
- Where
- 10 sites in Japan
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
PD - Parkinson's Disease
PAS Balance Training for Parkinson Disease (PD)
Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT06598891
- Testing
- Weight shift training and APA feedback, Paired associative stimulation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
Parkinson Disease
Study Evaluating Sumanirole for the Treatment of the Signs and Symptoms of Early Parkinson's Disease.
The primary purpose of this study is to determine whether sumanirole is effective and safe in the treatment of the signs and symptoms of early Parkinson's disease.
- Trial name
- NCT00036218
- Testing
- sumanirole, ropinirole
- Where
- 102 sites in United States, Argentina and 2 more
- Volunteers
- 600 people
- Sponsor
- Pfizer
Parkinson Disease, Balance
Non-motor Symptoms, Balance, Muscle Strength, and Functional Mobility in Patients With Parkinson's Disease
The purposes of this study is to examine balance, muscle strength, and mobility in relation with non-motor symptoms (NMSs) in patients with Parkinsosn's Disease (PD).
- Conditions
- Parkinson Disease, Balance, Muscle Strength, Mobility
- Trial name
- NCT04420910
- Testing
- Non-Motor Symptoms, Balance, Lower Limb Strength
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Parkinson's Disease With Freezing of Gait
Validation of cueStim for Reduction of Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn if the cueStim device can reduce the duration of freezing of gait (FoG) that occurs in patients with Parkinson's Disease.
- Trial name
- NCT07675408
- Testing
- CueStim
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Fortis Medical Devices Limited
Parkinson's Disease
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
The purpose of the proposed study is to demonstrate that the functional outcomes of DBS surgery utilizing the "asleep" technique are not inferior to those reported for traditional "awake" DBS technique.
- Trial name
- NCT02401308
- Testing
- Deep Brain Stimulation surgery
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Parkinson's Disease
Safety of CERE-120 (AAV2-NTN) in Subjects With Idiopathic Parkinson's Disease
This is a Phase I dose escalating open-label study designed to assess the safety, tolerability and biologic activity of an in vivo AAV2 mediated delivery of the gene encoding NTN (CERE-120).
- Trial name
- NCT00252850
- Testing
- CERE-120: AAV2-NTN
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Sangamo Therapeutics
Dementia, Motor Neuron Disease
Digital App for Speech & Health Monitoring
Many people living with neurodegenerative conditions like dementia, motor neuron disease (MND), multiple sclerosis (MS), and Parkinson's disease (PD), suffer from speech problems.
- Conditions
- Dementia, Motor Neuron Disease, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT06450418
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Parkinson Disease
Learning Potential of Patients With Parkinson's Disease After Two Weeks of Targeted Touchscreen Training
Parkinson's disease (PD) is characterized by severe motor and non-motor symptoms, including upper limb dysfunction. Due to the degradation of dopaminergic neurons in the striatum, PD patients experience difficulties with motor…
- Trial name
- NCT05696197
- Testing
- Targeted touchscreen training
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- KU Leuven
Parkinson Disease
Acceptability of the Somnomat Casa for the Treatment of Parkinson's Disease
This pilot study aims to evaluate the feasibility and acceptability of nocturnal translational vestibular stimulations (VS) applied by a rocking bed (Somnomat Casa) for two months in patients with Parkinson's Disease.
- Trial name
- Somnomat Casa (NCT06386497)
- Testing
- Nocturnal translational vestibular stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease
PS128 May Improve Off Duration on Parkinson's Disease
The purpose of this study is to investigate the short term effects (12 Weeks) of Lactobacillus plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms.
- Trial name
- NCT04389762
- Testing
- daily ingestion of Lactobacillus plantarum PS128
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- Professor Lu Neurological Clinic
Parkinson Disease
Parkinson Disease Telerehabilitation Program (PDTR): a Home-motor Program. A Pilot Study.
Parkinson's disease (PD) leads to multifactorial disabilities with consequent social restrictions, especially in the COVID-19 era.
- Trial name
- NCT05762562
- Testing
- Telerehabilitation with open source platforms
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Parkinson Disease, Constipation
Orally Administered ENT-01 for Parkinson's Disease-Related Constipation Follow-on Safety "Roll-over" Study (Rollover)
This study will be conducted as an open-label safety follow-on to a multi-center, double-blind, randomized study. All subjects who participated in the randomized study will be offered participation in this unblinded, single-arm…
- Trial name
- Rollover (NCT04483479)
- Testing
- Active Investigational Treatment ENT-01
- Where
- 18 sites in United States
- Volunteers
- 27 people
- Sponsor
- Enterin Inc.
Parkinson Disease
Exercise and Sleep in Parkinson's Disease
This study will investigate the impact of two common exercise modalities, cardiovascular and resistance training, on sleep quality and architecture in persons with Parkinson's disease (PD), and whether these potential positive…
- Trial name
- NCT04558879
- Testing
- CT, RT
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
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