Clinical trials: Paraplegia, Spinal
Paraplegia
High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04397250
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Paraplegia, Upper Limb Pain
Adjusting Wheelchair Set-Up to Minimize Shoulder Joint Forces During Propulsion
Individuals who use a manual wheelchair depend upon their upper limbs to provide a means of locomotion during completion of their activities of daily living.
- Trial name
- NCT00785278
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Paraplegia, Spinal Cord Injuries
Natural History of Shoulder Pathology in Manual Wheelchair Users
Over 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level…
- Conditions
- Paraplegia, Spinal Cord Injuries, Shoulder Pain, Tendinopathy
- Trial name
- NHSSI (NCT02600910)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Paraplegia
High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04011137
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron diseases, as well as other neurodegenerative…
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, Primary Lateral Sclerosis, Nervous System Diseases
- Trial name
- BIO_ALS-01 (NCT00677768)
- Testing
- No intervention
- Where
- 30 sites in United States, Canada
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI
This study aims to demonstrate the safety and effectiveness of the Eve personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06777576
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI (Site 2)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06814015
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Myelomeningocele, Spinal Cord Injury
Reciprocating Gait Orthoses for Paraplegia Patients
Ambulation would bring many physiological and psychological benefits and getting up and walking has been a dream for paraplegia patients.The reciprocating gait orthoses (RGOs) for paraplegics particularly draws research…
- Conditions
- Myelomeningocele, Spinal Cord Injury, Spinal Muscular Atrophy
- Trial name
- UPGO (NCT02227407)
- Testing
- RGOs(reciprocating gait orthoses)
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spinal Cord Injuries, Shoulder Impingement Syndrome
Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia
Shoulder pain is very common in people with spinal cord injury (SCI). Persons with high-level paraplegia have higher chances to suffer shoulder pain and injury than those with lower-level paraplegia due to the shoulder muscle…
- Trial name
- FUS (NCT02357914)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia
Phenotype, Genotype and Biomarkers 2
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- PGB2 (NCT04875416)
- Where
- 4 sites in United States, South Africa
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cardiovascular Disease
Spinal Cord Injury: Endurance, Strength and Cardiac Function Induced by Efficient Training Protocols
1. Measurements of peak oxygen uptake (VO2peak) during passive leg cycling (PLC) combined with arm crank ergometry (ACE), leg vascular occlusion (100mmHg above systolic BP) combined with ACE, and FES isometric contractions…
- Trial name
- NCT00987155
- Testing
- Ergometry
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Incomplete Spinal Cord Injury, Brown Sequard Syndrome
Walking Adaptability Post-Spinal Cord Injury
The purpose of this study is: (1) to establish assessment techniques (in our laboratory) to identify the functional integrity of long spinal tracts associated with adaptive walking recovery post-spinal cord injury and (2) to…
- Trial name
- NCT01851629
- Testing
- Locomotor Training, Cross-Sectional Testing (No Intervention)
- Where
- 4 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Florida
Spinal Cord Injuries, Tetraplegia
Human Factors Validation Testing of the Wandercraft Personal Exoskeleton
The goal of this interventional, national, prospective, open and monocentric study is to demonstrate that a personal exoskeleton can be used by the intended users without serious use errors or problems, for the intended uses and…
- Conditions
- Spinal Cord Injuries, Tetraplegia, Paraplegia
- Trial name
- ExoUser (NCT06715631)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Hereditary Spastic Paraplegia, Spastic Ataxia
TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias
Ataxias, hereditary spastic paraplegias (HSP), and spastic ataxias (collectively referred to as SPAX diseases) are rare neurological conditions that cause progressive problems with walking, balance, coordination, and daily…
- Trial name
- TreatHSP (NCT07798674)
- Where
- 30 sites in Austria, Czechia and 7 more
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Spinal Cord Injuries, Paraplegia
Assessment of Vasomotion of People With Spinal Cord Injury
Spinal cord injury (SCI), causes loss of supra-spinal control of the sympathetic nervous system and in some cases loss of sensation.
- Trial name
- NCT04215939
- Testing
- Cold environment participants with spinal cord injury, Thermoneutral environment participants with spinal cord injury, Warm environment participants with spinal cord injury
- Where
- Greece
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Spinal Cord Injuries, Paraplegia, Spinal
Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
The central objective of this study is to validate new algorithms that coordinate between functional electrical stimulation (FES) and the exoskeleton during sitting-to-standing, walking, and standing-to-sitting movements.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT04453943
- Testing
- Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Paraplegia and Tetraplegia
Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury
The purpose of this study is to evaluate whether there are functional improvements in arm muscles and movments for spinal cord injured indviduals after performing video gaming.
- Trial name
- NCT01537978
- Testing
- Video gaming for enhanced function after spinal cord injury.
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level
Neuromodulation With Spinal Stimulation Methods
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT06272279
- Testing
- spinal stimulation-DCS, spinal stimulation-EPS
- Where
- 2 sites in Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Spinal Cord Injuries
Postprandial Lipid Tracer and Exercise in Spinal Cord Injury
This study investigates the effect of upper extremity exercise on postprandial lipemia (PPL) in persons with spinal cord injury (SCI).
- Trial name
- PPLT (NCT03691532)
- Testing
- Seated control (CON), Arm cycle exercise (ACE), Liquid meal
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development