Clinical trials: Para-Aortic Lymph Node Metastasis
Synchronous Isolated Para-aortic Lymph Node Metastasis, Colorectal Cancer
Systemic Therapy Sequenced Isolated PALND for mCRC
The study aims to estimate the efficacy and safety of systemic therapy sequenced radical surgery in treating patients with synchronous isolated para-aortic lymph node metastasis of colorectal cancer.
- Trial name
- NCT04774757
- Testing
- Para-aortic lymph node dissection
- Where
- China
- Volunteers
- 39 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Pancreas Cancer, Pancreas Adenocarcinoma
Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer
Lymph node metastases are a strong prognostic predictor for pancreatic cancer. Para-aortic lymph nodes (PALN) are the final nodes for periampullary cancers before the cancer cells enter the systemic lymphatic circulation.
- Conditions
- Pancreas Cancer, Pancreas Adenocarcinoma, Lymph Node Metastasis
- Trial name
- PALN (NCT06065891)
- Testing
- PALN resection
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 300 people
- Sponsor
- Jon Unosson
Prostate Adenocarcinoma, Iliac Nodal Disease
Elective Adaptive Radiation With SBRT for Improved DurabilitY of Response
This prospective, single-arm feasibility study will include patients with prostate cancer that have controlled local disease diagnosed with oligorecurrent para-aortic nodal disease and/or common iliac nodal disease detected by…
- Conditions
- Prostate Adenocarcinoma, Iliac Nodal Disease, Para-aortic Lymph Node Metastasis, Para-aortic Nodal Disease
- Trial name
- EASY (NCT06831032)
- Testing
- Adaptive radiotherapy using SBRT
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Pelvic and Para-aortic Lymph Node Metastases
Magnetic Resonance Imaging-guided Online Adaptive Radiotherapy of Pelvic Lymph Node Metastases
In this study, the investigators want to investigate whether online-adapted radiotherapy using a special magnetic resonance imaging (MRI) simulator and computed tomography (CT)-guided radiation therapy, is feasible and offers…
- Trial name
- MACULA (NCT07083648)
- Testing
- Magnetic resonance Imaging-guided online adaptive radiotherapy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Cisplatin and Radiation Therapy Followed by Paclitaxel and Carboplatin in Treating Patients With Stage IB-IVA Cervical Cancer
This phase I trial studies the side effects and the best dose of paclitaxel and carboplatin after cisplatin and radiation therapy in treating patients with stage IB-IVA cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage IB Cervical Cancer AJCC v6 and v7
- Trial name
- NCT01295502
- Testing
- Carboplatin, Cisplatin, External Beam Radiation Therapy
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Gynecologic Oncology Group
Gastric Cancer, Para-Aortic Lymph Node Metastasis
Radiomics-Based AI Model for Predicting Para-Aortic Lymph Node Metastasis in Gastric Cancer Patients
This study aims to develop and validate an artificial intelligence (AI) model based on radiomics features extracted from preoperative CT images to predict para-aortic lymph node (PALN) metastasis in patients with gastric cancer.
- Conditions
- Gastric Cancer, Para-Aortic Lymph Node Metastasis, Lymphatic Metastasis, Preoperative Imaging Assessment
- Trial name
- NCT06947096
- Testing
- Radiomics-Based AI Imaging Analysis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qun Zhao
Cervical Cancer
Radiation Therapy, Paclitaxel, and Cisplatin in Treating Patients With Cancer of the Cervix
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Paclitaxel and cisplatin may increase the effectiveness of radiation therapy by making the tumor cells more sensitive to the radiation.
- Trial name
- NCT00003377
- Testing
- cisplatin, paclitaxel, brachytherapy
- Where
- 13 sites in United States
- Volunteers
- 29 people
- Sponsor
- Gynecologic Oncology Group
Locally Advanced Cervical Cancer
A Prospective Study on the Prediction Model of Para-aortic Lymph Node Metastasis
The goal of this prospective single-arm trial is to investigate the accuracy and feasibility of the para-aortic lymph node metastasis prediction model in locally advanced cervical cancer, as well as its impact on patients'…
- Trial name
- NCT06068387
- Testing
- surgical staging
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Chongqing University Cancer Hospital
Locally Advanced Cervical Cancer
Predictors of Para-aortic Lymph Node Metastasis of Cervical Cancer
The goal of this observational study is to identify predictive factors and to develop a risk model predicting para-aortic lymph node metastasis in patients with locally advanced cervical cancer based on the analysis of surgical…
- Trial name
- NCT05717751
- Testing
- surgical staging
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Chongqing University Cancer Hospital
Advanced Gastric Cancer
Trial of Xeloda and Oxaliplatin (XELOX) as Neo-adjuvant Chemotherapy Followed by Surgery in Advanced Gastric Cancer Patients With Para-aortic Lymph Node Metastasis
Gastric cancer with para-aortic lymph node (PAN) involvement is regarded as advanced disease, and only chemotherapy is recommended from the guidelines.
- Trial name
- NCT02071043
- Testing
- Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shanghai Zhongshan Hospital
Cervical Cancer
A Study of Camrelizumab Combined With Concurrent Chemoradiation in Patients With Cervical Cancer
In this single-arm study, patient with cervical cancer who had recurrence of the pelvic wall after surgery ± Abdominal aortic lymph node metastasis will be included to evaluate the efficacy and safety of camrelizumab combined…
- Trial name
- NCT04974827
- Testing
- Camrelizumab, Cisplatin or Carboplatin
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Hunan Cancer Hospital
Cervical Squamous Cell Carcinoma, Adenosquamous Carcinoma
Extraperitoneal Para-aortic Lymph Node Dissection (EPLND) for Cervix
The goal of this clinical research study is to learn if a surgical procedure called an extraperitoneal laparoscopic lymphadenectomy followed by chemotherapy and tailored radiation therapy can help to control the disease for a…
- Conditions
- Cervical Squamous Cell Carcinoma, Adenosquamous Carcinoma, Adenocarcinoma, Locally Advanced Malignant Neoplasm
- Trial name
- NCT01365156
- Testing
- Extraperitoneal laparoscopic lymphadenectomy (EPLND), Chemoradiation
- Where
- 3 sites in United States, Belgium
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer, Gastric Cancer Metastatic to Regional Lymph Nodes
Concurrent Chemoradiotherapy Combined With Sintilimab as Neoadjuvant Therapy for GC Patients With PALM
This trial is a prospective, single arm, single center, phase II clinical study aimed at subjects with advanced gastric cancer and para aortic lymph node metastasis, exploring the feasibility and safety of Sintilimab Injection…
- Trial name
- NCT06341595
- Testing
- Sintilimab, Extraperitoneal radiation therapy, Oxaliplatin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Cancer, Retroperitoneal Lymph Node Metastasis
CRT Versus Surgery for Retroperitoneal or Paraaortic Lymph Node Recurrence of CRC
The study aims to compare the effects of chemoradiation versus radical surgery in treating retro-peritoneal or para-aortic lymph node metastasis in colorectal cancer.
- Conditions
- Colorectal Cancer, Retroperitoneal Lymph Node Metastasis, Para-aortic Lymph Node Metastasis
- Trial name
- NCT03725254
- Testing
- lymphadenectomy, chemoradiotherapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fudan University
Cervical Cancer
Prophylactic Irradiation of the Para-Aortic Lymph Nodes and Supraclavicular Lymph Nodes in Locally Advanced Uterine Cervical Cancer
This study is an open-label, randomized study, which is designed to investigate the efficacy of Extended-field irradiation (EFI) on reducing recurrences at the para-aortic lymph node (PAN) and supraclavicular lymph nodes, and…
- Trial name
- NCT01063387
- Testing
- Prophylactic Irradiation of the Para-Aortic Lymph Nodes and supraclavicular lymph nodes in Locally Advanced Uterine Cervical Cancer
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Gastric Cancer
Efficacy and Safety of Minimally Invasive D2+PAND Gastrectomy for Gastric Cancer With PAN Metastasis After Conversion Immunochemotherapy
This is a prospective, open-label, single-center, Phase II clinical trial. Thirty patients with HER2-negative gastric adenocarcinoma or gastroesophageal junction (GEJ) cancer, presenting with PAN metastasis (No.
- Trial name
- NCT07056010
- Testing
- curative minimally invasive gastrectomy with D2+PAND lymphadenectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastric Adenocarcinoma, Stomach Neoplasms
Conversion Therapy Plus Surgery and Radiotherapy for Retroperitoneal Nodal Metastases in Gastric Cancer
This is a randomized, controlled, multicenter phase II clinical trial evaluating the efficacy and safety of conversion therapy combined with radical gastrectomy and adjuvant radiotherapy targeting para-aortic (station 16) lymph…
- Trial name
- NCT07007182
- Testing
- SOX regimen, CAPEOX regimen, PD-1 inhibitor
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Jinbo Yue
Cervical Cancer, Adjuvant Chemotherapy
A Trial Comparing Adjuvant Chemotherapy With Observation After Concurrent Chemoradiotherapy of Cervical Cancer (With Pelvic or Para-aortic Node Involvement)
Cervical cancer with pelvic or para-aortic node involvement has a poor prognosis. Despite low-quality data, the routine practice to treat these patients is radiation with concurrent cisplatin.
- Conditions
- Cervical Cancer, Adjuvant Chemotherapy, Radiation, Lymph Node Metastases
- Trial name
- NCT03468010
- Testing
- chemoradiation, Paclitaxel, Cisplatin
- Where
- 8 sites in China
- Volunteers
- 432 people
- Sponsor
- Sun Yat-sen University