Clinical trials: Papillary Thyroid Microcarcinoma
Papillary Thyroid Microcarcinoma, Microbiome
Microbiome and Papillary Thyroid Microcarcinoma
It has been shown that gut microbiome and microbiome metabolism can regulate or control the initiation of a cancer process. To the best of the investigators knowledge, no study has directly shown the relationship of the thyroid…
- Trial name
- NCT04376203
- Testing
- Thyroidectomy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Papillary Thyroid Microcarcinoma
Radiofrequency Ablation Treatment of Low-Risk Papillary Thyroid Carcinomas
Researchers in this study aim to prove the safety and efficacy of radiofrequency ablation in the treatment of a carefully selected low-risk papillary thyroid microcarcinoma patient group.
- Trial name
- NCT07506161
- Testing
- Radiofrequency ablation alone
- Where
- Hungary
- Volunteers
- 27 people
- Sponsor
- Premier G Med Cardio Kft
Differentiated Thyroid Cancer (DTC), Papillary Thyroid Microcarcinoma
Decision Aid Efficacy in Low Risk Thyroid Cancer
Low-risk thyroid cancer grows very slowly. More than 99% of patients with this cancer survive for at least 5 years. There are 3 main treatment options: remove the whole thyroid, remove just the part of the thyroid with the cancer…
- Conditions
- Differentiated Thyroid Cancer (DTC), Papillary Thyroid Microcarcinoma, Papillary Thyroid Carcinoma
- Trial name
- NCT07536412
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Papillary Microcarcinoma of the Thyroid
Active Surveillance Versus Surgery in Thyroid Papillary Microcarcinoma
The primary objective of this study is to evaluate the outcome of two treatment approaches (immediate surgery or close follow-up) in patients with papillary thyroid microcarcinoma (mPTc) .
- Trial name
- MITICA (NCT04129281)
- Testing
- Surgery
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute, Naples
Papillary Thyroid Microcarcinoma
PMRA and Shapley-Based Machine Learning for Predicting Lymph Node Metastasis in Central Subregions of Clinically Node-Negative Papillary Thyroid Microcarcinoma: a Prospective Multicenter Validation and Development of a Web Calculator
Background:Management of clinically node-negative(cN0) papillary thyroid microcarcinoma (PTMC) is complicated by high occult lymph node metastasis (LNM) rates.
- Trial name
- PMRA (NCT06871956)
- Testing
- PMRA and Shapley-Based Machine Learning for Predicting Lymph Node Metastasis in Central Subregions of Clinically Node-Negative Papillary Thyroid Microcarcinoma
- Where
- China
- Volunteers
- 4,882 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Microwave Ablation, Contrast-enhanced Ultrasound
Efficacy and Prognosis of Microwave Ablation Treatment for Papillary Thyroid Microcarcinoma Assessed by Contrast-Enhanced Ultrasound Combined With Genetic and Molecular Diagnostics: A Prospective Observational Study
In 2016, there were 203,000 new cases of thyroid cancer in China, ranking 7th among all malignant tumours and 4th among women, and showing a rapid growth trend.
- Conditions
- Microwave Ablation, Contrast-enhanced Ultrasound, Genetic and Molecular Diagnostics, Papillary Thyroid Microcarcinoma
- Trial name
- NCT07054229
- Testing
- Contrast enhanced Ultrasound, 88-gene panel for thyroid cancer
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Cancer, Papillary
Active Surveillance of Papillary Thyroid Microcarcinoma
Papillary thyroid microcarcinoma are small thyroid cancer measuring 1cm or less. Most of this tumor are not palpable and are identified either through pathologic examination or from imaging modalities, such as CT scan or thyroid…
- Trial name
- NCT02952612
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Dong Jun Lim
Papillary Thyroid Cancer
Image-guided Thermal Ablation vs. Lobectomy for Solitary Papillary Thyroid Microcarcinoma
To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma
- Trial name
- NCT06325787
- Testing
- thyroid lobectomy, image-guided thermal ablation
- Volunteers
- 1,021 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer, Papillary Thyroid Microcarcinoma
Multicenter Comparison of Thermal Ablation Versus Thyroid Lobectomy for Subcapsular Papillary Thyroid Microcarcinoma
To compare the clinical outcomes of Thermal ablation with those of thyroid lobectomy in patients with subcapsular papillary thyroid microcarcinoma.
- Trial name
- NCT06583057
- Testing
- Thermal ablation, Thyroid lobectomy
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer, Papillary Microcarcinoma
Treatment Decision-Making Among Patients Diagnosed With Papillary Microcarcinoma and Their Significant Others
The purpose of this study is to understand more about why some patients choose to have surgery to treat their papillary microcarcinoma (PMC) and others choose to have their papillary microcarcinoma (PMC) regularly watched by…
- Trial name
- NCT01392222
- Testing
- Focus groups
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Papillary Thyroid Microcarcinoma, Radiofrequency Ablation
10 Years' Follow-up Results of Ultrasound-guided Radiofrequency Ablation Versus Surgery for Low-risk Papillary Thyroid Micro-carcinoma
Papillary thyroid micro-carcinoma (PTMC) generally demonstrates favorable prognosis. However, the potential risk of disease progression requires careful therapeutic consideration.
- Conditions
- Papillary Thyroid Microcarcinoma, Radiofrequency Ablation, Surgical Resection, Long-term Outcomes
- Trial name
- NCT07107503
- Testing
- Radiofrequency ablation alone, surgical resection
- Volunteers
- 757 people
- Sponsor
- Yi Mao
Papillary Thyroid Microcarcinoma
RFA Treatment for Papillary Thyroid Microcarcinoma
Thyroid surgery has always been the mainstay of treatment for thyroid cancer. Thyroid surgery carries a low risk of complications that include recurrent or superior laryngeal nerve injury leading to voice changes…
- Trial name
- NCT05189821
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Thyroid Cancer, Lymph Node Metastases
Predictive Factors of Lymph Node Metastasis in Patients With Papillary Microcarcinoma of the Thyroid
Papillary thyroid microcarcinoma (PTMC), defined as a tumor with larger diameter ≤ 1 cm, is considered a tumor with an indolent course and an excellent prognosis.
- Trial name
- NCT04274829
- Testing
- Thyroidecomt and lymphectomy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
Papillary Thyroid Microcarcinoma
Active Surveillance of Papillary Thyroid Microcarcinoma
The purpose of this study is to better understand the outcomes of active surveillance (observation) instead of immediate surgery, which is the current standard of care for papillary thyroid microcarcinoma (PTMC).
- Trial name
- PMCAS (NCT02609685)
- Testing
- Active Surveillance
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Cedars-Sinai Medical Center
Papillary Microcarcinoma
Genomic Predictors of Papillary Microcarcinoma Disease Progression
The study is being done to answer the following question: What are the specific clinical and molecular features that will help us predict which small thyroid cancers are likely to grow and be problematic? Therefore, the purpose…
- Trial name
- NCT02363595
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Papillary Thyroid Cancer, Papillary Thyroid Carcinoma
Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer
This is a prospective, observational, multi-center study examining the long-term outcomes of patients with small, low risk papillary thyroid cancer who offered the choice of active surveillance (close follow-up to monitor for…
- Conditions
- Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid
- Trial name
- NCT04624477
- Where
- 8 sites in Canada
- Volunteers
- 450 people
- Sponsor
- University Health Network, Toronto
Papillary Thyroid Microcarcinoma
Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
In this study, the investigators look at the genetic expressional alteration which influenced on the early lateral neck node metastasis in thyroid papillary microcarcinoma.
- Trial name
- NCT01384669
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Yonsei University
Thyroid Cancer
Impact of Papillary Microcarcinoma Terminology on Patients Treatment Preferences: a Cross Sectional Survey
To explore how a clinical sample of patients with thyroid nodules (men and women) with no history of thyroid cancer would make decisions about treatments based on different terminology used to describe papillary thyroid cancer…
- Trial name
- NCT02726282
- Where
- United States
- Sponsor
- Mayo Clinic
Carcinoma
Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Occult lymph node metastasis is common in micro papillary thyroid cancer. However, the role of lymph node dissection in the treatment of microPTC remains controversial.
- Trial name
- NCT01149161
- Testing
- Routine central neck dissection
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Papillary Thyroid Cancer
Radiofrequency Ablation of Papillary Thyroid Microcarcinoma
Traditionally, surgery has been the standard recommendation for treating papillary thyroid cancer. The risk of surgery including permanent hoarseness, permanent hypocalcemia, a mid-cervical scar, and the potential for permanent…
- Trial name
- NCT05132205
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University